(Q30453993)

English

Glutamate carboxypeptidase II and folate deficiencies result in reciprocal protection against cognitive and social deficits in mice: implications for neurodevelopmental disorders

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scholarly article

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22076974%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

Glutamate carboxypeptidase II and folate deficiencies result in reciprocal protection against cognitive and social deficits in mice: implications for neurodevelopmental disorders (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22076974%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

neurodevelopmental disorder

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22076974%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

author name string

Laura R Schaevitz

1

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22076974%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

Jonathan D Picker

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22076974%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

Nancy H Kolodny

4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22076974%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

Barry Shane

5

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22076974%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

Joanne E Berger-Sweeney

6

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22076974%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

Joseph T Coyle

7

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22076974%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

publication date

1 June 2012

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22076974%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

number of pages

15

1 reference

based on heuristic

inferred from page(s)

Developmental Neurobiology

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22076974%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

72

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22076974%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

6

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22076974%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

891-905

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22076974%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

Folic acid intake and spina bifida in the era of dietary folic acid fortification

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401954

20 June 2018

Prenatal vitamins, one-carbon metabolism gene variants, and risk for autism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401954

20 June 2018

Genomic and epigenomic instability, fragile sites, schizophrenia and autism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401954

20 June 2018

Prevention and schizophrenia--the role of dietary factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401954

20 June 2018

Early life programming and neurodevelopmental disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401954

20 June 2018

Global methylation profiling of lymphoblastoid cell lines reveals epigenetic contributions to autism spectrum disorders and a novel autism candidate gene, RORA, whose protein product is reduced in autistic brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401954

20 June 2018

The genetics of autism: key issues, recent findings, and clinical implications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401954

20 June 2018

Folate nutrition is related to neuropsychological functions in the elderly

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401954

20 June 2018

One-carbon metabolism and schizophrenia: current challenges and future directions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401954

20 June 2018

Epigenetics: definition, mechanisms and clinical perspective.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401954

20 June 2018

Localization of NAAG-related gene expression deficits to the anterior hippocampus in schizophrenia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401954

20 June 2018

Phenotypic characterization of mice heterozygous for a null mutation of glutamate carboxypeptidase II.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401954

20 June 2018

Neurochemical changes in the rat prefrontal cortex following acute phencyclidine treatment: an in vivo localized (1)H MRS study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401954

20 June 2018

Mthfd1 is an essential gene in mice and alters biomarkers of impaired one-carbon metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401954

20 June 2018

Cognitive impairment in folate-deficient rats corresponds to depleted brain phosphatidylcholine and is prevented by dietary methionine without lowering plasma homocysteine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401954

20 June 2018

Regulation of neuronal glutathione synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401954

20 June 2018

Allosteric modulation of NMDA receptor via elevation of brain glycine and D-serine: the therapeutic potentials for schizophrenia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401954

20 June 2018

Folate deficiency induces neurodegeneration and brain dysfunction in mice lacking uracil DNA glycosylase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401954

20 June 2018

Regulation of glutathione synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401954

20 June 2018

A mathematical model of glutathione metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401954

20 June 2018

Epigenomic profiling reveals DNA-methylation changes associated with major psychosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401954

20 June 2018

Dysregulation of glutamate carboxypeptidase II in psychiatric disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401954

20 June 2018

How environmental and genetic factors combine to cause autism: A redox/methylation hypothesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401954

20 June 2018

Catechol-O-methyltransferase (COMT): a gene contributing to sex differences in brain function, and to sexual dimorphism in the predisposition to psychiatric disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401954

20 June 2018

Parallel changes in metabolite and expression profiles in crooked-tail mutant and folate-reduced wild-type mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401954

20 June 2018

Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401954

20 June 2018

Do maternal folate and homocysteine levels play a role in neurodevelopmental processes that increase risk for schizophrenia?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401954

20 June 2018

Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401954

20 June 2018

Recent advances in the chemistry and biology of folypoly-gamma-glutamate synthetase substrates and inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401954

20 June 2018

Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401954

20 June 2018

B vitamins, homocysteine, and neurocognitive function in the elderly

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401954

20 June 2018

Glutathione efflux induced by NMDA and kainate: implications in neurotoxicity?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401954

20 June 2018

Folylpoly-gamma-glutamate carboxypeptidase from pig jejunum. Molecular characterization and relation to glutamate carboxypeptidase II.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401954

20 June 2018

Hydrolysis of the neuropeptide N-acetylaspartylglutamate (NAAG) by cloned human glutamate carboxypeptidase II.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401954

20 June 2018

The nagging question of the function of N-acetylaspartylglutamate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401954

20 June 2018

Neurotoxicity associated with dual actions of homocysteine at the N-methyl-D-aspartate receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401954

20 June 2018

Behavioral and neurochemical changes in folate-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401954

20 June 2018

Abnormal excitatory neurotransmitter metabolism in schizophrenic brains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401954

20 June 2018

Interactions Between N‐Acetylaspartylglutamate and AMPA, Kainate, and NMDA Binding Sites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401954

20 June 2018

Folylpolyglutamate synthesis and role in the regulation of one-carbon metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401954

20 June 2018

Is excess folic acid supplementation a risk factor for autism?

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.21000

21 January 2018

Impaired glutamine metabolism in NMDA receptor hypofunction induced by MK801.

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.21000

21 January 2018

Glutamate carboxypeptidase II: a polymorphism associated with lower levels of serum folate and hyperhomocysteinemia.

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.21000

21 January 2018

Schizophrenia: glutathione deficit in cerebrospinal fluid and prefrontal cortex in vivo.

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.21000

21 January 2018

Folate-mediated one-carbon metabolism

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.21000

21 January 2018

Glial-neuronal interactions are impaired in the schizophrenia model of repeated MK801 exposure.

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.21000

21 January 2018

Cerebral folate deficiency: a neurometabolic syndrome?

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.21000

21 January 2018

Depression and folate status in the US Population

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.21000

21 January 2018

Postnatal dietary choline supplementation alters behavior in a mouse model of Rett syndrome.

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.21000

21 January 2018

Has enhanced folate status during pregnancy altered natural selection and possibly Autism prevalence? A closer look at a possible link

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.21000

21 January 2018

Effects of a metabotropic glutamate receptor group II agonist LY354740 in animal models of positive schizophrenia symptoms and cognition

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.21000

21 January 2018

One-carbon metabolism in psychiatric illness

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.21000

21 January 2018

Orally active glutamate carboxypeptidase II inhibitor 2-MPPA attenuates dizocilpine-induced prepulse inhibition deficits in mice.

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.21000

21 January 2018

Increased transcription and activity of glutathione synthase in response to deficiencies in folate, vitamin E, and apolipoprotein E.

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.21000

21 January 2018

Neurochemical changes in a mouse model of Rett syndrome: changes over time and in response to perinatal choline nutritional supplementation.

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.21000

21 January 2018

The expression of prepulse inhibition of the acoustic startle reflex as a function of three pulse stimulus intensities, three prepulse stimulus intensities, and three levels of startle responsiveness in C57BL6/J mice.

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.21000

21 January 2018

Folate supplementation in schizophrenia: A possible role for MTHFR genotype

1 reference

https://api.crossref.org/works/10.1002%2FDNEU.21000

21 January 2018

In vivo and ex vivo evidence for ketamine-induced hyperglutamatergic activity in the cerebral cortex of the rat: Potential relevance to schizophrenia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401954

26 November 2018

Relations of glutamate carboxypeptidase II (GCPII) polymorphisms to folate and homocysteine concentrations and to scores of cognition, anxiety, and depression in a homogeneous Norwegian population: the Hordaland Homocysteine Study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401954

26 November 2018

Differential susceptibity of transgenic mice lacking one or both apolipoprotein alleles to folate and vitamin E deprivation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3401954

26 November 2018

N-acetylaspartylglutamate selectively activates mGluR3 receptors in transfected cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22076974

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurobiology of schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/22076974

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Folate deficiency during pregnancy impacts on methyl metabolism without affecting global DNA methylation in the rat fetus

1 reference

https://pubmed.ncbi.nlm.nih.gov/22076974

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lactobacillus casei microbiological assay of folic acid derivatives in 96-well microtiter plates

1 reference

https://pubmed.ncbi.nlm.nih.gov/22076974

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of free and total homocysteine in human plasma by high-performance liquid chromatography with fluorescence detection

1 reference

https://pubmed.ncbi.nlm.nih.gov/22076974

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamate carboxypeptidase II is expressed by astrocytes in the adult rat nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/22076974

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increase in the prevalence of the MTHFR 677 TT polymorphism in women born since 1959: potential implications for folate requirements

1 reference

https://pubmed.ncbi.nlm.nih.gov/22076974

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Attention deficit induced by blockade of N-methyl D-aspartate receptors in the prefrontal cortex is associated with enhanced glutamate release and cAMP response element binding protein phosphorylation: role of metabotropic glutamate receptors 2/3

1 reference

https://pubmed.ncbi.nlm.nih.gov/22076974

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic selection and folate intake during pregnancy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22076974

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1002/DNEU.21000

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22076974%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22076974%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22076974%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

ResearchGate publication ID

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