(Q30478035)

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TC-5619: an alpha7 neuronal nicotinic receptor-selective agonist that demonstrates efficacy in animal models of the positive and negative symptoms and cognitive dysfunction of schizophrenia

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scholarly article

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Europe PubMed Central

29 September 2017

TC-5619: an alpha7 neuronal nicotinic receptor-selective agonist that demonstrates efficacy in animal models of the positive and negative symptoms and cognitive dysfunction of schizophrenia (English)

1 reference

Europe PubMed Central

29 September 2017

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cognitive dysfunction

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based on heuristic

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author name string

T A Hauser

1

1 reference

Europe PubMed Central

29 September 2017

A Kucinski

2

1 reference

Europe PubMed Central

29 September 2017

K G Jordan

3

1 reference

Europe PubMed Central

29 September 2017

G J Gatto

4

1 reference

Europe PubMed Central

29 September 2017

S R Wersinger

5

1 reference

Europe PubMed Central

29 September 2017

R A Hesse

6

1 reference

Europe PubMed Central

29 September 2017

E K Stachowiak

7

1 reference

Europe PubMed Central

29 September 2017

M K Stachowiak

8

1 reference

Europe PubMed Central

29 September 2017

R L Papke

9

1 reference

Europe PubMed Central

29 September 2017

P M Lippiello

10

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Europe PubMed Central

29 September 2017

M Bencherif

11

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Europe PubMed Central

29 September 2017

language of work or name

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publication date

29 May 2009

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Europe PubMed Central

29 September 2017

Biochemical Pharmacology

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Europe PubMed Central

29 September 2017

78

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29 September 2017

803-812

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Europe PubMed Central

29 September 2017

7

1 reference

Europe PubMed Central

29 September 2017

Serotonergic hyperinnervation and effective serotonin blockade in an FGF receptor developmental model of psychosis

1 reference

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20 June 2018

Atypical antipsychotics as noncompetitive inhibitors of alpha4beta2 and alpha7 neuronal nicotinic receptors

1 reference

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20 June 2018

Extrapyramidal side-effects of antipsychotics in a randomised trial

1 reference

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20 June 2018

Discovery of N-[(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide as an agonist of the alpha7 nicotinic acetylcholine receptor: in vitro and in vivo activity

1 reference

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20 June 2018

Preclinical characterization of A-582941: a novel alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing properties

1 reference

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20 June 2018

Initial phase 2 trial of a nicotinic agonist in schizophrenia

1 reference

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Emerging opportunities for antipsychotic drug discovery in the postgenomic era.

1 reference

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20 June 2018

Integrative nuclear signaling in cell development--a role for FGF receptor-1.

1 reference

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20 June 2018

Broad-spectrum efficacy across cognitive domains by alpha7 nicotinic acetylcholine receptor agonism correlates with activation of ERK1/2 and CREB phosphorylation pathways

1 reference

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20 June 2018

An allosteric modulator of the alpha7 nicotinic acetylcholine receptor possessing cognition-enhancing properties in vivo

1 reference

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20 June 2018

Central nicotinic receptors: structure, function, ligands, and therapeutic potential.

1 reference

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20 June 2018

Dissecting the signaling pathway of nicotine-mediated neuroprotection in a mouse Alzheimer disease model

1 reference

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20 June 2018

Nicotinic acetylcholine receptors and nicotinic cholinergic mechanisms of the central nervous system

1 reference

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20 June 2018

SSR180711, a novel selective alpha7 nicotinic receptor partial agonist: (II) efficacy in experimental models predictive of activity against cognitive symptoms of schizophrenia.

1 reference

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20 June 2018

Genetics of chromosome 15q13-q14 in schizophrenia

1 reference

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20 June 2018

Dysregulation of thalamic sensory "transmission" in schizophrenia: neurochemical vulnerability to hallucinations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005247

20 June 2018

A novel positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005247

20 June 2018

The selective alpha7 nicotinic acetylcholine receptor agonist PNU-282987 [N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide hydrochloride] enhances GABAergic synaptic activity in brain slices and restores auditory gating deficits in anesthetize

1 reference

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20 June 2018

AR-R 17779 improves social recognition in rats by activation of nicotinic alpha7 receptors

1 reference

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20 June 2018

Schizophrenia: from phenomenology to neurobiology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005247

20 June 2018

Recent progress in the development of subtype selective nicotinic acetylcholine receptor ligands

1 reference

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20 June 2018

Safety, pharmacokinetics, and effects on cognitive function of multiple doses of GTS-21 in healthy, male volunteers

1 reference

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20 June 2018

Comparative pharmacology of rat and human alpha7 nAChR conducted with net charge analysis

1 reference

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20 June 2018

Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005247

20 June 2018

Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005247

20 June 2018

Psychosis: pathological activation of limbic thalamocortical circuits by psychomimetics and schizophrenia?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005247

20 June 2018

The alpha7-nicotinic acetylcholine receptor and the pathology of hippocampal interneurons in schizophrenia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005247

20 June 2018

Central nicotinic receptors, neurotrophic factors and neuroprotection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005247

20 June 2018

Localization of nicotinic receptor subunit mRNAs in monkey brain by in situ hybridization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005247

20 June 2018

AR-R17779, and alpha7 nicotinic agonist, improves learning and memory in rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005247

20 June 2018

Gamma frequency-range abnormalities to auditory stimulation in schizophrenia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005247

20 June 2018

Phencyclidine in the social interaction test: an animal model of schizophrenia with face and predictive validity

1 reference

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20 June 2018

Using an animal model of deficient sensorimotor gating to study the pathophysiology and new treatments of schizophrenia

1 reference

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20 June 2018

The heterocyclic substituted pyridine derivative (+/-)-2-(-3-pyridinyl)-1-azabicyclo[2.2.2]octane (RJR-2429): a selective ligand at nicotinic acetylcholine receptors

1 reference

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20 June 2018

Role of Ca2+ ions in nicotinic facilitation of GABA release in mouse thalamus.

1 reference

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20 June 2018

Nicotine-haloperidol interactions and cognitive performance in schizophrenics.

1 reference

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20 June 2018

The binding of L-[3H]nicotine to a single class of high affinity sites in rat brain membranes.

1 reference

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A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data

1 reference

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20 June 2018

Drug discrimination and neurochemical studies in alpha7 null mutant mice: tests for the role of nicotinic alpha7 receptors in dopamine release

1 reference

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26 November 2018

Preclinical Characterization of A-582941: A Novel α7 Neuronal Nicotinic Receptor Agonist with Broad Spectrum Cognition-Enhancing Properties

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005247

26 November 2018

Presynaptic alpha 7- and beta 2-containing nicotinic acetylcholine receptors modulate excitatory amino acid release from rat prefrontal cortex nerve terminals via distinct cellular mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005247

26 November 2018

Allosteric modulation of alpha 7 nicotinic receptors selectively depolarizes hippocampal interneurons, enhancing spontaneous GABAergic transmission.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005247

26 November 2018

The novel alpha7 nicotinic acetylcholine receptor agonist N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-7-[2-(methoxy)phenyl]-1-benzofuran-2-carboxamide improves working and recognition memory in rodents.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005247

26 November 2018

Acute intermittent nicotine treatment induces fibroblast growth factor-2 in the subventricular zone of the adult rat brain and enhances neuronal precursor cell proliferation.

1 reference

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26 November 2018

Antipsychotic clozapine inhibits the function of alpha7-nicotinic acetylcholine receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005247

26 November 2018

Hippocampal FGF-2 and FGFR1 mRNA expression in major depression, schizophrenia and bipolar disorder.

1 reference

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26 November 2018

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1 reference

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26 November 2018

Estimation of both the potency and efficacy of alpha7 nAChR agonists from single-concentration responses

1 reference

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1 reference

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26 November 2018

Effects of nicotine on cognitive deficits in schizophrenia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005247

26 November 2018

Evidence of association between smoking and alpha7 nicotinic receptor subunit gene in schizophrenia patients

1 reference

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26 November 2018

Effects of nicotine on leading saccades during smooth pursuit eye movements in smokers and nonsmokers with schizophrenia

1 reference

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26 November 2018

DMXB, an alpha7 nicotinic agonist, normalizes auditory gating in isolation-reared rats

1 reference

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26 November 2018

Neuroscience. Deconstructing schizophrenia.

1 reference

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26 November 2018

Effects of alpha 4/beta 2- and alpha 7-nicotine acetylcholine receptor agonists on prepulse inhibition of the acoustic startle response in rats and mice

1 reference

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26 November 2018

Long-term potentiation of excitatory inputs to brain reward areas by nicotine.

1 reference

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26 November 2018

Characterisation of the binding of [3H]methyllycaconitine: a new radioligand for labelling alpha 7-type neuronal nicotinic acetylcholine receptors.

1 reference

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26 November 2018

Auditory sensory gating, hippocampal volume, and catecholamine metabolism in schizophrenics and their siblings.

1 reference

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26 November 2018

Human post-mortem striatal alpha4beta2 nicotinic acetylcholine receptor density in schizophrenia and Parkinson's syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/19482012

12 December 2020

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10.1016/J.BCP.2009.05.030

1 reference

Europe PubMed Central

29 September 2017

1 reference

Europe PubMed Central

29 September 2017

1 reference

Europe PubMed Central

29 September 2017

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