(Q56853416)

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Preclinical Characterization of A-582941: A Novel α7 Neuronal Nicotinic Receptor Agonist with Broad Spectrum Cognition-Enhancing Properties

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scholarly article

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Preclinical Characterization of A-582941: A Novel α7 Neuronal Nicotinic Receptor Agonist with Broad Spectrum Cognition-Enhancing Properties (English)

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author name string

Karin R. Tietje

1

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David J. Anderson

2

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R. Scott Bitner

3

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Eric A. Blomme

4

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Paul J. Brackemeyer

5

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Clark A. Briggs

6

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Kaitlin E. Browman

7

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Dagmar Bury

8

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Peter Curzon

9

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Karla U. Drescher

10

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Jennifer M. Frost

11

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Ryan M. Fryer

12

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Gerard B. Fox

13

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Jens Halvard Gronlien

14

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Monika Håkerud

15

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Earl J. Gubbins

16

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Sabine Halm

17

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Richard Harris

18

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Rosalind J. Helfrich

19

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Kathy L. Kohlhaas

20

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Devalina Law

21

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John Malysz

22

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Kennan C. Marsh

23

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Ruth L. Martin

24

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Michael D. Meyer

25

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Angela L. Molesky

26

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Arthur L. Nikkel

27

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Stephani Otte

28

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Liping Pan

29

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Pamela S. Puttfarcken

30

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Richard J. Radek

31

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Holly M. Robb

32

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Eva Spies

33

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Kirsten Thorin-Hagene

34

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Jeffrey F. Waring

35

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Hilde Ween

36

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Hongyu Xu

37

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Murali Gopalakrishnan

38

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William H. Bunnelle

39

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publication date

March 2008

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CNS Neuroscience & Therapeutics

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14

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1

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65-82

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Molecular psychology: roles for the ERK MAP kinase cascade in memory

1 reference

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Schizophrenia, sensory gating, and nicotinic receptors

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21 January 2018

[3H]A-585539 [(1S,4S)-2,2-dimethyl-5-(6-phenylpyridazin-3-yl)-5-aza-2-azoniabicyclo[2.2.1]heptane], a novel high-affinity alpha7 neuronal nicotinic receptor agonist: radioligand binding characterization to rat and human brain

1 reference

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21 January 2018

Central role of alpha7 nicotinic receptor in differentiation of the stratified squamous epithelium

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Indirect modulation by alpha7 nicotinic acetylcholine receptors of noradrenaline release in rat hippocampal slices: interaction with glutamate and GABA systems and effect of nicotine withdrawal.

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21 January 2018

Nicotinic alpha 7 receptors: synaptic options and downstream signaling in neurons

1 reference

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21 January 2018

Broad-spectrum efficacy across cognitive domains by alpha7 nicotinic acetylcholine receptor agonism correlates with activation of ERK1/2 and CREB phosphorylation pathways

1 reference

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21 January 2018

SSR180711, a novel selective alpha7 nicotinic receptor partial agonist: (1) binding and functional profile

1 reference

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21 January 2018

Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholine receptors

1 reference

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21 January 2018

The novel alpha7 nicotinic acetylcholine receptor agonist N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-7-[2-(methoxy)phenyl]-1-benzofuran-2-carboxamide improves working and recognition memory in rodents.

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PSAB-OFP, a selective alpha 7 nicotinic receptor agonist, is also a potent agonist of the 5-HT3 receptor

1 reference

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21 January 2018

Profile of nicotinic acetylcholine receptor agonists ABT-594 and A-582941, with differential subtype selectivity, on delayed matching accuracy by young monkeys.

1 reference

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21 January 2018

Identification of SLURP-1 as an epidermal neuromodulator explains the clinical phenotype of Mal de Meleda

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A neuronal nicotinic acetylcholine receptor subunit (α7) is developmentally regulated and forms a homo-oligomeric channel blocked by α-BTX

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21 January 2018

Antisense knockdown of the rat alpha7 nicotinic acetylcholine receptor produces spatial memory impairment

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Nicotinic acetylcholine receptors and the regulation of neuronal signalling.

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The [3H]dofetilide binding assay is a predictive screening tool for hERG blockade and proarrhythmia: Comparison of intact cell and membrane preparations and effects of altering [K+]o

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The 5-HT3 agent N-(3-chlorophenyl)guanidine (MD-354) serves as a discriminative stimulus in rats and displays partial agonist character in a shrew emesis assay

1 reference

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Mal de Meleda (MDM) caused by mutations in the gene for SLURP-1 in patients from Germany, Turkey, Palestine, and the United Arab Emirates

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Nicotinic acetylcholine receptor subtypes involved in facilitation of GABAergic inhibition in mouse superficial superior colliculus

1 reference

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21 January 2018

Performance deficit of alpha7 nicotinic receptor knockout mice in a delayed matching-to-place task suggests a mild impairment of working/episodic-like memory

1 reference

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Effects of histamine H(3) receptor ligands GT-2331 and ciproxifan in a repeated acquisition avoidance response in the spontaneously hypertensive rat pup.

1 reference

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21 January 2018

Genomic organization and partial duplication of the human alpha7 neuronal nicotinic acetylcholine receptor gene (CHRNA7)

1 reference

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21 January 2018

Neuronal nicotinic receptors: from structure to pathology

1 reference

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21 January 2018

Brain nicotinic acetylcholine receptors: native subtypes and their relevance.

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A two-year study on the effects of nicotine and its withdrawal on mood and sleep

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Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis

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Impaired performance of alpha7 nicotinic receptor knockout mice in the five-choice serial reaction time task.

1 reference

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21 January 2018

A novel positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization.

1 reference

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21 January 2018

Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations

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Sensory gating deficit expressed by a disturbed suppression of the P50 event-related potential in patients with Alzheimer's disease.

1 reference

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A-366833: a novel nicotinonitrile-substituted 3,6-diazabicyclo[3.2.0]-heptane alpha4beta2 nicotinic acetylcholine receptor selective agonist: Synthesis, analgesic efficacy and tolerability profile in animal models.

1 reference

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Targeting the cholinergic system as a therapeutic strategy for the treatment of pain

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Efficacy of varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, vs placebo or sustained-release bupropion for smoking cessation: a randomized controlled trial

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21 January 2018

The cholinergic system in Alzheimer's disease

1 reference

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Poor Tolerability of a Transdermal Nicotine Treatment in Parkinson's Disease

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Association of promoter variants in the alpha7 nicotinic acetylcholine receptor subunit gene with an inhibitory deficit found in schizophrenia

1 reference

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Presynaptic ionotropic receptors and the control of transmitter release.

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The 5-HT3 antagonist tropisetron (ICS 205-930) is a potent and selective alpha7 nicotinic receptor partial agonist

1 reference

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21 January 2018

Laminar distribution of nicotinic receptor subtypes in cortical regions in schizophrenia.

1 reference

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Nicotine exposure and bronchial epithelial cell nicotinic acetylcholine receptor expression in the pathogenesis of lung cancer

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(-)-Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin-2'-one], a conformationally restricted analogue of acetylcholine, is a highly selective full agonist at the alpha 7 nicotinic acetylcholine receptor

1 reference

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Medicinal chemical properties of successful central nervous system drugs

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Neuronal nicotinic acetylcholine receptor subunit knockout mice: physiological and behavioral phenotypes and possible clinical implications.

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SSR180711, a novel selective alpha7 nicotinic receptor partial agonist: (II) efficacy in experimental models predictive of activity against cognitive symptoms of schizophrenia.

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Muscarinic and nicotinic modulation of cortical acetylcholine release monitored by in vivo microdialysis in freely moving adult rats

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Alpha4beta2 nicotinic receptor stimulation contributes to the effects of nicotine in the DBA/2 mouse model of sensory gating.

1 reference

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The -2 bp deletion in exon 6 of the 'alpha 7-like' nicotinic receptor subunit gene is a risk factor for the P50 sensory gating deficit

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Drug-induced prolongation of the QT interval

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Nicotinic receptors in the development and modulation of CNS synapses.

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Interaction of tobacco-specific toxicants with the neuronal alpha(7) nicotinic acetylcholine receptor and its associated mitogenic signal transduction pathway: potential role in lung carcinogenesis and pediatric lung disorders

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Nicotinic cholinergic signaling in hippocampal astrocytes involves calcium-induced calcium release from intracellular stores

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Pharmacological characterization of nicotinic receptor-mediated acetylcholine release in rat brain--an in vivo microdialysis study

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(R)-3'-(3-methylbenzo[b]thiophen-5-yl)spiro[1-azabicyclo[2,2,2]octane-3,5'-oxazolidin]-2'-one, a novel and potent alpha7 nicotinic acetylcholine receptor partial agonist displays cognitive enhancing properties.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2008.00037.X

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ERK 1/2 signaling pathway is involved in nicotine-mediated neuroprotection in spinal cord neurons.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2008.00037.X

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Effect of maintenance therapy with varenicline on smoking cessation: a randomized controlled trial

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Lipophilicity in PK design: methyl, ethyl, futile

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Design, synthesis, structure-activity relationship, and in vivo activity of azabicyclic aryl amides as alpha7 nicotinic acetylcholine receptor agonists

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Role of neuronal nicotinic receptors in the effects of nicotine and ethanol on contextual fear conditioning

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Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells

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Nicotine promotes cell proliferation via alpha7-nicotinic acetylcholine receptor and catecholamine-synthesizing enzymes-mediated pathway in human colon adenocarcinoma HT-29 cells

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Presynaptic nicotinic ACh receptors

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Transdermal nicotine and haloperidol in Tourette's disorder: a double-blind placebo-controlled study.

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Modulators of nicotinic acetylcholine receptors as analgesics.

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Impaired attention is central to the cognitive deficits observed in alpha 7 deficient mice

1 reference

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Molecular cloning, functional properties, and distribution of rat brain alpha 7: a nicotinic cation channel highly permeable to calcium.

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Identifiers

10.1111/J.1527-3458.2008.00037.X

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