(Q35147376)

6 August 2017

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title

An update on in vitro test methods in human hepatic drug biotransformation research: pros and cons (English)

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6 August 2017

Esther F A Brandon

1

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6 August 2017

Christiaan D Raap

2

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6 August 2017

Irma Meijerman

3

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6 August 2017

Jos H Beijnen

4

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6 August 2017

Jan H M Schellens

5

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6 August 2017

1 June 2003

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Toxicology and Applied Pharmacology

6 August 2017

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6 August 2017

189

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6 August 2017

233-246

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6 August 2017

3

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The dependence of hepatic function upon sufficient oxygen supply during prolonged isolated rat liver perfusion

6 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

Preservation and inducibility of xenobiotic metabolism in long-term cultures of adult rat liver cell aggregates

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

6alpha-hydroxylation of taurochenodeoxycholic acid and lithocholic acid by CYP3A4 in human liver microsomes

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

Utility of hepatocytes to model species differences in the metabolism of loxtidine and to predict pharmacokinetic parameters in rat, dog and man

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

Techniques for pharmacological and toxicological studies with isolated hepatocyte suspensions

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

In vitro approaches can predict human drug metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

Population expansion, clonal growth, and specific differentiation patterns in primary cultures of hepatocytes induced by HGF/SF, EGF and TGF alpha in a chemically defined (HGM) medium

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

Isolated rat liver preparation; bile production and other basic properties

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

Protective effects of coffee diterpenes against aflatoxin B1-induced genotoxicity: mechanisms in rat and human cells

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

Barriers to the acceptance of in vitro alternatives

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

Human cell lines, derived from AHH-1 TK+/- human lymphoblasts, genetically engineered for expression of cytochromes P450.

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

In-vitro metabolism of anti-cancer drugs, methods and applications: paclitaxel, docetaxel, tamoxifen and ifosfamide

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

A commentary on the use of hepatocytes in drug metabolism studies during drug discovery and development

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

Kinetics of ranitidine metabolism in dog and rat isolated hepatocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

Induction of cytochrome P450 1A1 gene expression, oxidative stress, and genotoxicity by carbaryl and thiabendazole in transfected human HepG2 and lymphoblastoid cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

Biotransformation of trichloroethylene in collagen gel sandwich cultures of rat hepatocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

V79 Chinese hamster cells genetically engineered for cytochrome P450 and their use in mutagenicity and metabolism studies

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

The influence of culture medium composition on drug metabolising enzyme activities of the human liver derived Hep G2 cell line

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

Past, present, and future applications of precision-cut liver slices for in vitro xenobiotic metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

Present and future in vitro approaches for drug metabolism.

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

High-performance liquid chromatographic assay to detect hydroxylate and conjugate metabolites of propofol in human urine.

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

The paradoxical effect of acetaminophen on CYP3A4 activity and content in transfected HepG2 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

The role of hepatic and extrahepatic UDP-glucuronosyltransferases in human drug metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

Human liver quality is a dominant factor in the outcome of in vitro studies

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

N-acetyltransferase-dependent activation of 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine: formation of 2-amino-1-methyl-6-(5-hydroxy)phenylimidazo [4,5-b]pyridine, a possible biomarker for the reactive dose of 2-amino-1-methyl-6-phenylimid

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

Relevance of multidrug resistance proteins for intestinal drug absorption in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

Extensive metabolism of the flavonoid chrysin by human Caco-2 and Hep G2 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

Use of transgenic cell lines in mechanistic studies of drug metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

Time-dependent expression of cytochrome P450 genes in primary cultures of well-differentiated human hepatocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

Expression and induction of a large set of drug-metabolizing enzymes by the highly differentiated human hepatoma cell line BC2.

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

Primary culture of adult rat hepatocytes after 48-hour preservation of the liver with cold UW solution.

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

Advantage of the use of human liver S9 in the Ames test

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

Stability of cytochrome P450 proteins in cultured precision-cut rat liver slices

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

Cryopreserved primary hepatocytes as a constantly available in vitro model for the evaluation of human and animal drug metabolism and enzyme induction

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

Selective induction of cytochrome P450 3A1 by dexamethasone in cultured rat hepatocytes: analysis with a novel reverse transcriptase-polymerase chain reaction assay section sign

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

The enzymatic preparation of isolated intact parenchymal cells from rat liver

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

Transport and metabolic characterization of Caco-2 cells expressing CYP3A4 and CYP3A4 plus oxidoreductase

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

Role of human liver microsomal CYP3A4 and CYP2B6 in catalyzing N-dechloroethylation of cyclophosphamide and ifosfamide

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

Primary cultures of rat hepatocytes in hollow fiber chambers.

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

Re-expression of C/EBPα induces CYP2B6, CYP2C9 and CYP2D6 genes in HepG2 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

In vitro toxicology in hepatocyte bioreactors-extracellular acidification rate (EAR) in a target cell line indicates hepato-activated transformation of substrates

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

A new instrument for the rapid preparation of tissue slices

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

3,3'-Diindolylmethane induces CYP1A2 in cultured precision-cut human liver slices

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

Induction of CYP3A isoforms in cultured precision-cut human liver slices

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

Induction of cytochrome P450 isoenzymes in cultured precision-cut rat and human liver slices

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

Species differences in metabolism of ketotifen in rat, rabbit and man: demonstration of similar pathways in vivo and in cultured hepatocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

Increased cytotoxicity of food-borne mycotoxins toward human cell lines in vitro via enhanced cytochrome p450 expression using the MTT bioassay

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

Debenzylation of O(6)-benzyl-8-oxoguanine in human liver: implications for O(6)-benzylguanine metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

Identification of enzymes responsible for rifalazil metabolism in human liver microsomes

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

Graphical model for estimating oral bioavailability of drugs in humans and other species from their Caco-2 permeability and in vitro liver enzyme metabolic stability rates

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

Revised methods for the Salmonella mutagenicity test

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

Kupffer cell-mediated differential down-regulation of cytochrome P450 metabolism in rat hepatocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

Liver slices in in vitro pharmacotoxicology with special reference to the use of human liver tissue

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

Influence of 48 hours of cold storage in University of Wisconsin organ preservation solution on metabolic capacity of rat hepatocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

Pig hepatocytes as an in vitro model to study the regulation of human CYP3A4: prediction of drug-drug interactions with 17 alpha-ethynylestradiol

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

Cytochrome P-450-linked monooxygenase system and drug-induced spectral interactions in human liver microsomes

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

A simplification of the protein assay method of Lowry et al. which is more generally applicable

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

Use of V79 cells with stably transfected cytochrome P450 cDNAs in studying the metabolism and effects of cytotoxic drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

Use of precision-cut rat liver slices for studies of xenobiotic metabolism and toxicity: comparison of the Krumdieck and Brendel tissue slicers.

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

An update on high-yield hepatocyte isolation methods and on the potential clinical use of isolated liver cells

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

Estrogen receptor reduces CYP1A1 induction in cultured human endometrial cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

Nitric oxide-independent suppression of P450 2C11 expression by interleukin-1beta and endotoxin in primary rat hepatocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

A comparative study of precision cut liver slices, hepatocytes, and liver microsomes from the Wistar rat using metronidazole as a model substance

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

Induction of cytochrome-P450 in cryopreserved rat and human hepatocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

Expression changes of CYP2A and CYP3A in microsomes from pig liver and cultured hepatocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

Dynamic organ culture of precision liver slices for in vitro toxicology.

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

An in vitro reporter gene assay method incorporating metabolic activation with human and rat S9 or liver microsomes

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

Selegiline metabolism and cytochrome P450 enzymes: in vitro study in human liver microsomes

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

Optimizing drug development: strategies to assess drug metabolism/transporter interaction potential--towards a consensus

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

Human-derived cell lines to study xenobiotic metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

Differential sensitivity of rat hepatocyte CYP isoforms to self-generated nitric oxide.

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

Drug and xenobiotic glucuronidation catalysed by cloned human liver UDP-Glucuronosyltransferases stably expressed in tissue culture cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

In vitro metabolic products of RWJ-34130, an antiarrythmic agent, in rat liver preparations.

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

Fluvoxamine-theophylline interaction: gap between in vitro and in vivo inhibition constants toward cytochrome P4501A2.

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

In vitro and in vivo models for assessing drug efflux transporter activity

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

Oxidative metabolism of bunitrolol by complementary DNA-expressed human cytochrome P450 isozymes in a human hepatoma cell line (Hep G2) using recombinant vaccinia virus.

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

Metabolism of anabolic steroids by recombinant human cytochrome P450 enzymes. Gas chromatographic-mass spectrometric determination of metabolites.

1 reference

https://api.crossref.org/works/10.1016%2FS0041-008X%2803%2900128-5

7 January 2021

10.1016/S0041-008X(03)00128-5

Identifiers

DOI

1 reference

6 August 2017

1 reference