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Ultrasound for drug and gene delivery to the brain
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scholarly article
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Europe PubMed Central
PMCID
2504014
retrieved
16 August 2017
review article
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Europe PubMed Central
title
Ultrasound for drug and gene delivery to the brain
(English)
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stated in
Europe PubMed Central
PMCID
2504014
retrieved
16 August 2017
author
Kullervo Hynynen
series ordinal
1
object named as
Kullervo Hynynen
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Europe PubMed Central
PMCID
2504014
retrieved
16 August 2017
language of work or name
English
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publication date
6 April 2008
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Europe PubMed Central
PMCID
2504014
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16 August 2017
published in
Advanced Drug Delivery Reviews
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stated in
Europe PubMed Central
PMCID
2504014
retrieved
16 August 2017
volume
60
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stated in
Europe PubMed Central
PMCID
2504014
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16 August 2017
issue
10
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Europe PubMed Central
PMCID
2504014
retrieved
16 August 2017
page(s)
1209-1217
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Europe PubMed Central
PMCID
2504014
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16 August 2017
cites work
Effect of focused ultrasound applied with an ultrasound contrast agent on the tight junctional integrity of the brain microvascular endothelium
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20 June 2018
Effects of acoustic parameters and ultrasound contrast agent dose on focused-ultrasound induced blood-brain barrier disruption
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20 June 2018
Blood-brain barrier disruption induced by focused ultrasound and circulating preformed microbubbles appears to be characterized by the mechanical index
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PubMed Central
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20 June 2018
Clinical applications of focused ultrasound-the brain.
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20 June 2018
Targeted delivery of doxorubicin to the rat brain at therapeutic levels using MRI-guided focused ultrasound
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20 June 2018
Use of ultrasound pulses combined with Definity for targeted blood-brain barrier disruption: a feasibility study
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20 June 2018
Brain arterioles show more active vesicular transport of blood-borne tracer molecules than capillaries and venules after focused ultrasound-evoked opening of the blood-brain barrier
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PubMed Central
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20 June 2018
Focal disruption of the blood-brain barrier due to 260-kHz ultrasound bursts: a method for molecular imaging and targeted drug delivery
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PubMed Central
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20 June 2018
Noninvasive localized delivery of Herceptin to the mouse brain by MRI-guided focused ultrasound-induced blood-brain barrier disruption
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PubMed Central
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20 June 2018
Multiphoton imaging of ultrasound/Optison mediated cerebrovascular effects in vivo.
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20 June 2018
Targeted delivery of antibodies through the blood-brain barrier by MRI-guided focused ultrasound
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20 June 2018
Local and reversible blood-brain barrier disruption by noninvasive focused ultrasound at frequencies suitable for trans-skull sonications
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Therapeutic applications of lipid-coated microbubbles.
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20 June 2018
Effect of heat preconditioning on the uptake and permeability of R123 in brain microvessel endothelial cells during mild heat treatment
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20 June 2018
Progress and problems in the neurological applications of focused ultrasound
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20 June 2018
Ultrasonically produced changes in the blood-brain barrier.
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20 June 2018
Morphology and molecular properties of cellular components of normal cerebral vessels
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20 June 2018
Experimental demonstration of noninvasive transskull adaptive focusing based on prior computed tomography scans
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20 June 2018
Drug and gene delivery to the brain: the vascular route
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504014
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20 June 2018
A non-invasive method for focusing ultrasound through the human skull
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504014
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20 June 2018
Noninvasive MR imaging-guided focal opening of the blood-brain barrier in rabbits
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504014
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20 June 2018
Clinical trials of single-agent trastuzumab (Herceptin).
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PubMed Central
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20 June 2018
Improved selective, simple, and contrast staining of acidophilic neurons with vanadium acid fuchsin
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20 June 2018
Safety and efficacy of a multicenter study using intraarterial chemotherapy in conjunction with osmotic opening of the blood-brain barrier for the treatment of patients with malignant brain tumors.
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20 June 2018
Acoustic radiation force in vivo: a mechanism to assist targeting of microbubbles
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PubMed Central
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20 June 2018
Outwitting the blood-brain barrier for therapeutic purposes: osmotic opening and other means
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20 June 2018
Demonstration of potential noninvasive ultrasound brain therapy through an intact skull.
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20 June 2018
Transporting therapeutics across the blood-brain barrier
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PubMed Central
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20 June 2018
Acoustic cavitation: a possible consequence of biomedical uses of ultrasound
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PubMed Central
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20 June 2018
Ultrasound augmentation of central nervous system tumor therapy.
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20 June 2018
Studies on the in vivo disposition of adriamycin in human tumours which exhibit different responses to the drug
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20 June 2018
The physiology of the blood-brain barrier.
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20 June 2018
Ultrasound and the blood-brain barrier.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504014
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20 June 2018
Treatment of malignant brain tumors with focused ultrasound hyperthermia and radiation: results of a phase I trial
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20 June 2018
Treatment for patients with cerebral metastases
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PubMed Central
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20 June 2018
In vivo transcranial brain surgery with an ultrasonic time reversal mirror.
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26 November 2018
Quantitative evaluation of focused ultrasound with a contrast agent on blood-brain barrier disruption.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504014
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26 November 2018
Noninvasive, transcranial and localized opening of the blood-brain barrier using focused ultrasound in mice.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504014
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26 November 2018
Blood-brain barrier disruption by low-frequency ultrasound.
1 reference
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PubMed Central
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26 November 2018
Targeted disruption of the blood-brain barrier with focused ultrasound: association with cavitation activity.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504014
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26 November 2018
Osmotic blood-brain barrier disruption chemotherapy for diffuse pontine gliomas
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504014
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26 November 2018
MRI-guided targeted blood-brain barrier disruption with focused ultrasound: histological findings in rabbits
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504014
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26 November 2018
A numerical study of transcranial focused ultrasound beam propagation at low frequency
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26 November 2018
Cellular mechanisms of the blood-brain barrier opening induced by ultrasound in presence of microbubbles.
1 reference
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PubMed Central
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26 November 2018
500-element ultrasound phased array system for noninvasive focal surgery of the brain: a preliminary rabbit study with ex vivo human skulls.
1 reference
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PubMed Central
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26 November 2018
MRI investigation of the threshold for thermally induced blood-brain barrier disruption and brain tissue damage in the rabbit brain.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504014
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26 November 2018
P32 uptake by normal and ultrasonically irradiated brain tissue from cerebrospinal fluid.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504014
retrieved
26 November 2018
Central nervous system metastases in women who receive trastuzumab-based therapy for metastatic breast carcinoma.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504014
retrieved
26 November 2018
The threshold for brain damage in rabbits induced by bursts of ultrasound in the presence of an ultrasound contrast agent (OptisonĀ®)
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504014
retrieved
26 November 2018
High-intensity focused ultrasound selectively disrupts the blood-brain barrier in vivo.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504014
retrieved
26 November 2018
Observation on the integrity of the blood-brain barrier after microbubble destruction by diagnostic transcranial color-coded sonography
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504014
retrieved
26 November 2018
Optison (FS069) disrupts the blood-brain barrier in rats.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504014
retrieved
26 November 2018
Blood-brain barrier disruption in experimental focal ischemia: comparison between in vivo MRI and immunocytochemistry.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504014
retrieved
26 November 2018
Histologic effects of high intensity pulsed ultrasound exposure with subharmonic emission in rabbit brain in vivo.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2504014
retrieved
26 November 2018
Fundamental neurological research and human neurosurgery using intense ultrasound
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/18486271
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Enhanced ultrasound transmission through the human skull using shear mode conversion
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/18486271
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.ADDR.2008.03.010
1 reference
stated in
Europe PubMed Central
PMCID
2504014
retrieved
16 August 2017
PMCID
2504014
1 reference
stated in
Europe PubMed Central
PMCID
2504014
retrieved
16 August 2017
PubMed ID
18486271
1 reference
stated in
Europe PubMed Central
PMCID
2504014
retrieved
16 August 2017
ResearchGate publication ID
5364820
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