(Q30494108)

16 September 2017

Phase II trial of CoQ10 for ALS finds insufficient evidence to justify phase III. (English)

1 reference

amyotrophic lateral sclerosis

16 September 2017

phase II clinical trial

0 references

phase III clinical trial

0 references

1 reference

inferred from title

author

Terry Heiman-Patterson

20

object named as

Terry Heiman-Patterson

1 reference

16 September 2017

Catherine Lomen-Hoerth

12

object named as

Catherine Lomen-Hoerth

1 reference

16 September 2017

27

Hiroshi Mitsumoto

1 reference

16 September 2017

Petra Kaufmann

1

1 reference

16 September 2017

John L P Thompson

2

1 reference

16 September 2017

Gilberto Levy

3

1 reference

16 September 2017

Richard Buchsbaum

4

1 reference

16 September 2017

Jeremy Shefner

5

1 reference

16 September 2017

Lisa S Krivickas

6

1 reference

16 September 2017

Jonathan Katz

7

1 reference

16 September 2017

Yvonne Rollins

8

1 reference

16 September 2017

Richard J Barohn

9

1 reference

16 September 2017

Carlayne E Jackson

10

1 reference

16 September 2017

Ezgi Tiryaki

11

1 reference

16 September 2017

Carmel Armon

13

1 reference

16 September 2017

Rup Tandan

14

1 reference

16 September 2017

Stacy A Rudnicki

15

1 reference

16 September 2017

Kourosh Rezania

16

1 reference

16 September 2017

Robert Sufit

17

1 reference

16 September 2017

Alan Pestronk

18

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16 September 2017

Steven P Novella

19

1 reference

16 September 2017

Edward J Kasarskis

21

1 reference

16 September 2017

Erik P Pioro

22

1 reference

16 September 2017

Jacqueline Montes

23

1 reference

16 September 2017

Rachel Arbing

24

1 reference

16 September 2017

Darleen Vecchio

25

1 reference

16 September 2017

Alexandra Barsdorf

26

1 reference

16 September 2017

Bruce Levin

28

1 reference

16 September 2017

QALS Study Group

29

1 reference

16 September 2017

1 August 2009

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16 September 2017

1 reference

16 September 2017

66

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16 September 2017

2

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16 September 2017

235-244

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Nutrition and dietary supplements in motor neuron disease

16 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

Adaptive clinical trials: progress and challenges

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

Oxidative stress biomarkers in sporadic ALS

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

Genetics of familial amyotrophic lateral sclerosis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

The role of Coenzyme Q in mitochondrial electron transport

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

Clinical trials of coenzyme Q10 in neurological disorders

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

A responsive outcome for Parkinson's disease neuroprotection futility studies

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

Vitamin E intake and risk of amyotrophic lateral sclerosis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

High dose vitamin E therapy in amyotrophic lateral sclerosis as add-on therapy to riluzole: results of a placebo-controlled double-blind study

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

ALS issues in clinical trials. Missing data

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

High throughput drug screening

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

Pilot trial of high dosages of coenzyme Q10 in patients with Parkinson's disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

Effects of Coenzyme Q10 in Huntington's disease and early Parkinson's disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

Cu/Zn superoxide dismutase (SOD1) mutations associated with familial amyotrophic lateral sclerosis (ALS) affect cellular free radical release in the presence of oxidative stress

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

Coenzyme Q10 as a possible treatment for neurodegenerative diseases

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

Biochemical functions of coenzyme Q10

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

Dietary coenzyme Q10 and vitamin E alter the status of these compounds in rat tissues and mitochondria

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

Changes in the normal maximal expiratory flow-volume curve with growth and aging

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

The MOS 36-ltem Short-Form Health Survey (SF-36)

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

Increased mitochondrial oxidative damage and oxidative DNA damage contributes to the neurodegenerative process in sporadic amyotrophic lateral sclerosis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

Excellent inter‐rater, intra‐rater, and telephone‐administered reliability of the ALSFRS‐R in a multicenter clinical trial

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

A two-stage design for a phase II clinical trial of coenzyme Q10 in ALS.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

26 November 2018

The utility of futility.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

Proteomic analysis of 4-hydroxy-2-nonenal-modified proteins in G93A-SOD1 transgenic mice--a model of familial amyotrophic lateral sclerosis

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

The ALSFRSr predicts survival time in an ALS clinic population.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

An increase of oxidized coenzyme Q-10 occurs in the plasma of sporadic ALS patients

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

Increased lipid peroxidation in sera of ALS patients: a potential biomarker of disease burden

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

A randomized, placebo-controlled trial of topiramate in amyotrophic lateral sclerosis

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

An outcome study of riluzole in amyotrophic lateral sclerosis--a population-based study in Ireland, 1996-2000.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

Mitochondrial electron transport chain complex dysfunction in a transgenic mouse model for amyotrophic lateral sclerosis

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

Mitochondrial DNA and respiratory chain function in spinal cords of ALS patients

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function. BDNF ALS Study Group (Phase III).

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

Incidence and prevalence of ALS in Ireland, 1995-1997: a population-based study.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

Performance of the Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS) in multicenter clinical trials.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

Onset, natural history and outcome in idiopathic adult motor neuron disease

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854625

Effect of coenzyme Q(10) and alpha-tocopherol content of mitochondria on the production of superoxide anion radicals

26 November 2018

1 reference

12 December 2020

Amyotrophic lateral sclerosis in Olmsted County, Minnesota, 1925 to 1998

1 reference

12 December 2020

The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus

1 reference

12 December 2020

Incidence and prevalence of amyotrophic lateral sclerosis in Harris County, Texas, 1985-1988

1 reference

12 December 2020

Dose-ranging study of riluzole in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis/Riluzole Study Group II

1 reference

12 December 2020

A carbon column-based liquid chromatography electrochemical approach to routine 8-hydroxy-2'-deoxyguanosine measurements in urine and other biologic matrices: a one-year evaluation of methods

1 reference

12 December 2020

Applying a phase II futility study design to therapeutic stroke trials

1 reference

12 December 2020

Tolerance of high-dose (3,000 mg/day) coenzyme Q10 in ALS

1 reference

12 December 2020

Increased mitochondrial oxidative damage in patients with sporadic amyotrophic lateral sclerosis

1 reference

12 December 2020

Identifiers

DOI

10.1002/ANA.21743

1 reference

16 September 2017

1 reference

16 September 2017

1 reference