(Q30496589)

19 October 2017

The structural basis for substrate anchoring, active site selectivity, and product formation by P450 PikC from Streptomyces venezuelae (English)

1 reference

(11Z)-6-[4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-13-hydroxy-3,5,7,9,13-pentamethyl-1-oxacyclotetradec-11-ene-2,4,10-trione

19 October 2017

Streptomyces venezuelae

1 reference

1 reference

1 reference

1 reference

David H Sherman

1

1 reference

19 October 2017

Shengying Li

2

1 reference

19 October 2017

Liudmila V Yermalitskaya

3

1 reference

19 October 2017

Youngchang Kim

4

1 reference

19 October 2017

Jarrod A Smith

5

1 reference

19 October 2017

Michael R Waterman

6

1 reference

19 October 2017

Larissa M Podust

7

1 reference

19 October 2017

language of work or name

English

0 references

publication date

6 July 2006

1 reference

full work available at URL

19 October 2017

http://www.jbc.org/article/S0021925819351592/pdf

1 reference

19 March 2024

https://api.unpaywall.org/v2/10.1074/jbc.m605478200?email=unpaywall_01@example.com

published in

Journal of Biological Chemistry

1 reference

19 October 2017

281

1 reference

19 October 2017

36

1 reference

19 October 2017

26289-26297

1 reference

https://api.unpaywall.org/v2/10.1074/jbc.m605478200?email=unpaywall_01@example.com

19 October 2017

1 reference

19 March 2024

access restriction status

open access

1 reference

based on heuristic

inferred from online access status

cites work

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1 reference

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Ribosomal antibiotics: structural basis for resistance, synergism and selectivity

20 June 2018

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The macrolide-bacterium interaction and its biological basis

20 June 2018

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Mechanism of oxidation reactions catalyzed by cytochrome p450 enzymes.

20 June 2018

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Hydroxylation by the hydroperoxy-iron species in cytochrome P450 enzymes

20 June 2018

1 reference

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An open conformation of mammalian cytochrome P450 2B4 at 1.6-Å resolution

20 June 2018

1 reference

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THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. II. SOLUBILIZATION, PURIFICATION, AND PROPERTIES

20 June 2018

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Crystal structures of epothilone D-bound, epothilone B-bound, and substrate-free forms of cytochrome P450epoK

20 June 2018

1 reference

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The enzymology of combinatorial biosynthesis

20 June 2018

1 reference

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Structural insight into the role of the ribosomal tunnel in cellular regulation

20 June 2018

1 reference

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Structural basis for the antibiotic activity of ketolides and azalides

20 June 2018

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Drugs of the 21st century: telithromycin (HMR 3647)--the first ketolide

20 June 2018

1 reference

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Modification of post-PKS tailoring steps through combinatorial biosynthesis

20 June 2018

1 reference

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Thermophilic cytochrome P450 (CYP119) from Sulfolobus solfataricus: high resolution structure and functional properties

20 June 2018

1 reference

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The structures of four macrolide antibiotics bound to the large ribosomal subunit

20 June 2018

1 reference

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Macrolides: present and future. An appraisal of in-vitro activity and pharmacokinetic behavior.

20 June 2018

1 reference

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Heme-Containing Oxygenases

20 June 2018

1 reference

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Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria

20 June 2018

1 reference

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Macrolides: structures and microbial targets

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939096

Construction of desosamine containing polyketide libraries using a glycosyltransferase with broad substrate specificity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939096

Biosynthesis and combinatorial biosynthesis of pikromycin-related macrolides in Streptomyces venezuelae

20 June 2018

1 reference

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Tolerance and specificity of polyketide synthases

20 June 2018

1 reference

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Crystal structure of a thermophilic cytochrome P450 from the archaeon Sulfolobus solfataricus

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939096

Combinatorial biosynthesis for new drug discovery

20 June 2018

1 reference

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939096

Epoxidation of olefins by cytochrome P450: evidence from site-specific mutagenesis for hydroperoxo-iron as an electrophilic oxidant

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939096

Genetic manipulation of antibiotic-producing Streptomyces

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939096

VMD: visual molecular dynamics

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939096

Crystal structure of hemoprotein domain of P450BM-3, a prototype for microsomal P450's

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939096

Structure of cytochrome P450eryF involved in erythromycin biosynthesis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939096

Role of protonated and neutral forms of macrolides in binding to ribosomes from gram-positive and gram-negative bacteria

20 June 2018

1 reference

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Improved methods for building protein models in electron density maps and the location of errors in these models

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939096

Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes.

20 June 2018

1 reference

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Generation of multiple bioactive macrolides by hybrid modular polyketide synthases in Streptomyces venezuelae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M605478200

Hydroxylation of macrolactones YC-17 and narbomycin is mediated by the pikC-encoded cytochrome P450 in Streptomyces venezuelae

21 January 2018

1 reference

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Neopikromycin and novapikromycin from the pikromycin biosynthetic pathway of Streptomyces venezuelae.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M605478200

Isolation and structure determination of novamethymycin, a new bioactive metabolite of the methymycin biosynthetic pathway in Streptomyces venezuelae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M605478200

Processing of X-ray diffraction data collected in oscillation mode

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M605478200

PROCHECK: a program to check the stereochemical quality of protein structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M605478200

Crystallographic study on the dioxygen complex of wild-type and mutant cytochrome P450cam. Implications for the dioxygen activation mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M605478200

What factors affect the regioselectivity of oxidation by cytochrome p450? A DFT study of allylic hydroxylation and double bond epoxidation in a model reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M605478200

Epoxidation of olefins by hydroperoxo-ferric cytochrome P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M605478200

The catalytic mechanism of cytochrome P450 BM3 involves a 6 Å movement of the bound substrate on reduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M605478200

Biosynthesis of desosamine: construction of a new macrolide carrying a genetically designed sugar moiety

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16825192

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M605478200

1 reference

19 October 2017

1 reference

19 October 2017

PubMed publication ID

16825192

1 reference