(Q30498491)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21368114%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

title

Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice (English)

1 reference

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24 January 2020

1

1 reference

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24 January 2020

Adeel Safdar

2

1 reference

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24 January 2020

Jonathan P. Little

5

1 reference

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24 January 2020

13

Mark A Tarnopolsky

1 reference

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24 January 2020

author name string

Jacqueline M Bourgeois

3

1 reference

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24 January 2020

Daniel I Ogborn

4

1 reference

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24 January 2020

Bart P Hettinga

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21368114%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Mahmood Akhtar

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21368114%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

James E Thompson

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21368114%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Simon Melov

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21368114%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Nicholas J Mocellin

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21368114%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Gregory C Kujoth

11

1 reference

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24 January 2020

Tomas A Prolla

12

1 reference

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24 January 2020

language of work or name

English

0 references

publication date

22 February 2011

1 reference

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24 January 2020

significant event

expression of concern

point in time

19 June 2018

1 reference

Editorial Expression of Concern: Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice

published in

Proceedings of the National Academy of Sciences of the United States of America

1 reference

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24 January 2020

volume

108

1 reference

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24 January 2020

issue

10

1 reference

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24 January 2020

page(s)

4135-4140

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21368114%20AND%20SRC:MED&resulttype=core&format=json

Dysfunctional Nrf2-Keap1 redox signaling in skeletal muscle of the sedentary old.

24 January 2020

cites work

1 reference

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Mitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator mice

20 June 2018

1 reference

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Aberrant mitochondrial homeostasis in the skeletal muscle of sedentary older adults

20 June 2018

1 reference

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A systematic review of the evidence for Canada's Physical Activity Guidelines for Adults

20 June 2018

1 reference

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Somatic mitochondrial DNA mutations in mammalian aging

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3053975

The effect of exercise training on anxiety symptoms among patients: a systematic review.

20 June 2018

1 reference

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Therapeutic approaches to mitochondrial dysfunction in Parkinson's disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3053975

Exercise performance by hemodialysis patients: a review of the literature

20 June 2018

1 reference

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Physical inactivity and obesity: relation to asthma and chronic obstructive pulmonary disease?

20 June 2018

1 reference

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Physical activity and prevention of cardiovascular disease in older adults

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3053975

Retracted: Increased muscle PGC-1α expression protects from sarcopenia and metabolic disease during aging

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3053975

Skeletal muscle autophagy and apoptosis during aging: effects of calorie restriction and life-long exercise

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3053975

The role of mitochondria in health and disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3053975

Physical activity, obesity and risk for esophageal adenocarcinoma.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3053975

Erythroid dysplasia, megaloblastic anemia, and impaired lymphopoiesis arising from mitochondrial dysfunction

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3053975

Exercise as an anti-inflammatory intervention to combat inflammatory diseases of muscle

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3053975

Random point mutations with major effects on protein-coding genes are the driving force behind premature aging in mtDNA mutator mice.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3053975

The changing shape of mitochondrial apoptosis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3053975

Impaired PGC-1alpha function in muscle in Huntington's disease.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3053975

The biology of PGC-1α and its therapeutic potential

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3053975

PGC-1alpha/beta induced expression partially compensates for respiratory chain defects in cells from patients with mitochondrial disorders.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3053975

Endurance exercise is protective for mice with mitochondrial myopathy

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3053975

Exercise: it's the real thing!

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3053975

Exercise and adrenaline increase PGC-1{alpha} mRNA expression in rat adipose tissue

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3053975

Reduced disability and mortality among aging runners: a 21-year longitudinal study

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3053975

The role of exercise and PGC1alpha in inflammation and chronic disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3053975

Depletion of mitochondrial DNA in fibroblast cultures from patients with POLG1 mutations is a consequence of catalytic mutations

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3053975

Strong purifying selection in transmission of mammalian mitochondrial DNA

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3053975

Systemic and mitochondrial adaptive responses to moderate exercise in rodents

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3053975

Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3053975

The transcriptional corepressor RIP140 regulates oxidative metabolism in skeletal muscle

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3053975

Mitochondrial diseases: therapeutic approaches

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3053975

PGC-1alpha regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3053975

PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3053975

Mitochondrial DNA mutations, apoptosis, and the misfolded protein response.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3053975

A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3053975

Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3053975

Cardiac disease due to random mitochondrial DNA mutations is prevented by cyclosporin A.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3053975

Premature ageing in mice expressing defective mitochondrial DNA polymerase

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3053975

Epidemiology of anemia in the elderly: information on diagnostic evaluation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3053975

Clonally expanded mtDNA point mutations are abundant in individual cells of human tissues

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3053975

Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3053975

Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3053975

The biologic clock: the mitochondria?

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3053975

What is the cause of the ageing atrophy? Total number, size and proportion of different fiber types studied in whole vastus lateralis muscle from 15- to 83-year-old men.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3053975

Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3053975

Biochemical Adaptations to Endurance Exercise in Muscle

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3053975

Somatic mitochondrial DNA mutations in single neurons and glia.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3053975

Accumulation of point mutations in mitochondrial DNA of aging mice

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3053975

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3053975

High levels of mitochondrial DNA deletions in skeletal muscle of old rhesus monkeys

26 November 2018

1 reference

12 December 2020

Increased longevity and refractoriness to Ca(2+)-dependent neurodegeneration in Surf1 knockout mice

1 reference

12 December 2020

Ageing muscle: clonal expansions of mitochondrial DNA point mutations and deletions cause focal impairment of mitochondrial function

1 reference

12 December 2020

Mitochondrial Diseases and Myopathies: A Series of Muscle Biopsy Specimens with Ultrastructural Changes in the Mitochondria

1 reference

12 December 2020

Physical activity, function, and longevity among the very old

1 reference

12 December 2020

A Morphometric Study of the Density of Mitochondrial Cristae in Heart and Liver of Aging Mice

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1019581108

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21368114%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21368114%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

PubMed publication ID

21368114

1 reference