(Q30499188)

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Delayed postnatal loss of P/Q-type calcium channels recapitulates the absence epilepsy, dyskinesia, and ataxia phenotypes of genomic Cacna1a mutations.

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25 January 2020

Delayed postnatal loss of P/Q-type calcium channels recapitulates the absence epilepsy, dyskinesia, and ataxia phenotypes of genomic Cacna1a mutations (English)

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25 January 2020

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Jeffrey L. Noebels

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25 January 2020

Stefan Herlitze

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25 January 2020

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Melanie D Mark

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25 January 2020

Takashi Maejima

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25 January 2020

Denise Kuckelsberg

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25 January 2020

Jong W Yoo

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25 January 2020

Robert A Hyde

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Viral Shah

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Davina Gutierrez

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Rosa L Moreno

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Wolfgang Kruse

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1 March 2011

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25 January 2020

Journal of Neuroscience

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25 January 2020

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25 January 2020

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25 January 2020

4311-4326

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25 January 2020

CaV2.1 channelopathies

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20 June 2018

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Synaptic inhibition of Purkinje cells mediates consolidation of vestibulo-cerebellar motor learning.

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20 June 2018

Low-frequency oscillations in the cerebellar cortex of the tottering mouse

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20 June 2018

Calcium channel regulation and presynaptic plasticity

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20 June 2018

The basal ganglia and cerebellum interact in the expression of dystonic movement

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20 June 2018

The ducky(2J) mutation in Cacna2d2 results in reduced spontaneous Purkinje cell activity and altered gene expression

1 reference

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20 June 2018

Decreases in the precision of Purkinje cell pacemaking cause cerebellar dysfunction and ataxia

1 reference

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20 June 2018

Function and dysfunction of synaptic calcium channels: insights from mouse models

1 reference

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20 June 2018

Determinants of postsynaptic Ca2+ signaling in Purkinje neurons

1 reference

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20 June 2018

Evolving concepts on the pathophysiology of absence seizures: the cortical focus theory

1 reference

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20 June 2018

Targeting mechanisms of high voltage-activated Ca2+ channels

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20 June 2018

Neocortical seizures: initiation, development and cessation

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20 June 2018

Presynaptic Ca2+ channels: a functional patchwork

1 reference

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20 June 2018

Impairment of LTD and cerebellar learning by Purkinje cell-specific ablation of cGMP-dependent protein kinase I

1 reference

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Inhibitory interconnections control burst pattern and emergent network synchrony in reticular thalamus.

1 reference

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20 June 2018

Competitive and synergistic interactions of G protein beta(2) and Ca(2+) channel beta(1b) subunits with Ca(v)2.1 channels, revealed by mammalian two-hybrid and fluorescence resonance energy transfer measurements

1 reference

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20 June 2018

Paroxysmal dyskinesias in the lethargic mouse mutant

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3065835

20 June 2018

Abnormal cerebellar signaling induces dystonia in mice.

1 reference

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20 June 2018

Ducky mouse phenotype of epilepsy and ataxia is associated with mutations in the Cacna2d2 gene and decreased calcium channel current in cerebellar Purkinje cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3065835

20 June 2018

Dystonia and cerebellar atrophy in Cacna1a null mice lacking P/Q calcium channel activity

1 reference

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20 June 2018

Rocker is a new variant of the voltage-dependent calcium channel gene Cacna1a

1 reference

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20 June 2018

Cre recombinase expression in cerebellar Purkinje cells.

1 reference

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20 June 2018

Molecular spectroscopy and dynamics of intrinsically fluorescent proteins: coral red (dsRed) and yellow (Citrine).

1 reference

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20 June 2018

Structure and regulation of voltage-gated Ca2+ channels

1 reference

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20 June 2018

Reduced voltage sensitivity of activation of P/Q-type Ca2+ channels is associated with the ataxic mouse mutation rolling Nagoya (tg(rol))

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3065835

20 June 2018

Tottering mouse motor dysfunction is abolished on the Purkinje cell degeneration (pcd) mutant background

1 reference

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20 June 2018

Developmental changes in calcium channel types mediating central synaptic transmission.

1 reference

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20 June 2018

Ablation of P/Q-type Ca(2+) channel currents, altered synaptic transmission, and progressive ataxia in mice lacking the alpha(1A)-subunit

1 reference

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20 June 2018

Single gene defects in mice: the role of voltage-dependent calcium channels in absence models

1 reference

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20 June 2018

Ataxic mouse mutants and molecular mechanisms of absence epilepsy

1 reference

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20 June 2018

Morphologic investigation of rolling mouse Nagoya (tg(rol)/tg(rol)) cerebellar Purkinje cells: an ataxic mutant, revisited

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20 June 2018

Ionic currents underlying spontaneous action potentials in isolated cerebellar Purkinje neurons.

1 reference

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20 June 2018

Protamine-Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cells

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20 June 2018

Absence epilepsy in tottering mutant mice is associated with calcium channel defects

1 reference

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20 June 2018

Stimulation of neurite outgrowth in PC12 cells by EGF and KCl depolarization: a Ca(2+)-independent phenomenon

1 reference

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20 June 2018

Exocytotic Ca2+ channels in mammalian central neurons

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20 June 2018

Electrophysiological properties of in vitro Purkinje cell dendrites in mammalian cerebellar slices

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20 June 2018

Electrophysiological properties of in vitro Purkinje cell somata in mammalian cerebellar slices

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20 June 2018

Spatially resolved calcium dynamics of mammalian Purkinje cells in cerebellar slice

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20 June 2018

The functional states of the thalamus and the associated neuronal interplay

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20 June 2018

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20 June 2018

A promoter that drives transgene expression in cerebellar Purkinje and retinal bipolar neurons

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20 June 2018

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

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20 June 2018

The thalamic clock: emergent network properties.

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20 June 2018

P-type calcium channels in rat central and peripheral neurons

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20 June 2018

P-type calcium channels blocked by the spider toxin ω-Aga-IVA

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20 June 2018

Inherited epilepsy: spike-wave and focal motor seizures in the mutant mouse tottering

1 reference

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20 June 2018

Striking pattern of Purkinje cell loss in cerebellum of an ataxic mutant mouse, tottering

1 reference

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26 November 2018

Purkinje cell input to cerebellar nuclei in tottering: ultrastructure and physiology.

1 reference

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26 November 2018

A CaV2.1 calcium channel mutation rocker reduces the number of postsynaptic AMPA receptors in parallel fiber-Purkinje cell synapses

1 reference

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26 November 2018

Conditional inactivation of the Cacna1a gene in transgenic mice

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26 November 2018

RGS2 determines short-term synaptic plasticity in hippocampal neurons by regulating Gi/o-mediated inhibition of presynaptic Ca2+ channels

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26 November 2018

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26 November 2018

Impaired motor function in mice with cell-specific knockout of sodium channel Scn8a (NaV1.6) in cerebellar purkinje neurons and granule cells

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26 November 2018

Relative contributions of axonal and somatic Na channels to action potential initiation in cerebellar Purkinje neurons.

1 reference

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26 November 2018

Increased noise level of purkinje cell activities minimizes impact of their modulation during sensorimotor control.

1 reference

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26 November 2018

Calcium-activated potassium channels are selectively coupled to P/Q-type calcium channels in cerebellar Purkinje neurons.

1 reference

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26 November 2018

Dendritic control of spontaneous bursting in cerebellar Purkinje cells.

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26 November 2018

Ionic Mechanisms of Burst Firing in Dissociated Purkinje Neurons

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26 November 2018

Somatic and dendritic small-conductance calcium-activated potassium channels regulate the output of cerebellar Purkinje neurons.

1 reference

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26 November 2018

Active contribution of dendrites to the tonic and trimodal patterns of activity in cerebellar Purkinje neurons.

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26 November 2018

Triggers of paroxysmal dyskinesia in the calcium channel mouse mutant tottering

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26 November 2018

The ducky mutation in Cacna2d2 results in altered Purkinje cell morphology and is associated with the expression of a truncated alpha 2 delta-2 protein with abnormal function

1 reference

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26 November 2018

An ultrastructural study of granule cell/Purkinje cell synapses in tottering (tg/tg), leaner (tg(la)/tg(la)) and compound heterozygous tottering/leaner (tg/tg(la)) mice

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26 November 2018

Resurgent sodium current and action potential formation in dissociated cerebellar Purkinje neurons.

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26 November 2018

Mutation of the Ca2+ channel beta subunit gene Cchb4 is associated with ataxia and seizures in the lethargic (lh) mouse

1 reference

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26 November 2018

Presynaptic Ca(2+) influx at a mouse central synapse with Ca(2+) channel subunit mutations

1 reference

https://pubmed.ncbi.nlm.nih.gov/21411672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated thalamic low-voltage-activated currents precede the onset of absence epilepsy in the SNAP25-deficient mouse mutant coloboma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21411672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changes in synaptic transmission properties due to the expression of N-type calcium channels at the calyx of Held synapse of mice lacking P/Q-type calcium channels

1 reference

https://pubmed.ncbi.nlm.nih.gov/21411672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A thin slice preparation for patch clamp recordings from neurones of the mammalian central nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/21411672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SCA1 transgenic mice: A model for neurodegeneration caused by an expanded CAG trinucleotide repeat

1 reference

https://pubmed.ncbi.nlm.nih.gov/21411672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.5342-10.2011

1 reference

Europe PubMed Central

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25 January 2020

PMC publication ID

1 reference

Europe PubMed Central

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25 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21411672%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

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