(Q30502491)

13 October 2017

Classification and characterization of therapeutic antibody aggregates (English)

1 reference

13 October 2017

1 reference

Marisa K Joubert

1

1 reference

13 October 2017

Quanzhou Luo

2

1 reference

13 October 2017

Yasser Nashed-Samuel

3

1 reference

13 October 2017

Jette Wypych

4

1 reference

13 October 2017

Linda O Narhi

5

1 reference

13 October 2017

language of work or name

English

0 references

publication date

25 March 2011

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Journal of Biological Chemistry

13 October 2017

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13 October 2017

286

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13 October 2017

28

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13 October 2017

25118-25133

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Chemical modifications in therapeutic protein aggregates generated under different stress conditions

13 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137085

The use of native cation-exchange chromatography to study aggregation and phase separation of monoclonal antibodies

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137085

An industry perspective on the monitoring of subvisible particles as a quality attribute for protein therapeutics

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137085

Critical evaluation of Nanoparticle Tracking Analysis (NTA) by NanoSight for the measurement of nanoparticles and protein aggregates

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137085

Protein aggregation--pathways and influencing factors

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137085

Application of vibrational spectroscopy to the structural characterization of monoclonal antibody and its aggregate

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137085

A critical review of analytical methods for subvisible and visible particles

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137085

Existence of different structural intermediates on the fibrillation pathway of human serum albumin.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137085

Protein aggregation kinetics, mechanism, and curve-fitting: a review of the literature.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137085

Protein aggregation: pathways, induction factors and analysis

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137085

Overlooking subvisible particles in therapeutic protein products: gaps that may compromise product quality

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137085

Extrinsic fluorescent dyes as tools for protein characterization

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137085

Immunogenicity of protein therapeutics

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137085

Mechanisms of action of immune tolerance induction against factor VIII in patients with congenital haemophilia A and factor VIII inhibitors

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137085

Effects of protein aggregates: an immunologic perspective

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137085

Immunogenicity of biopharmaceuticals

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137085

Protein folding and aggregation: two sides of the same coin in the condensation of proteins revealed by pressure studies

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137085

Colloidal behavior of proteins: effects of the second virial coefficient on solubility, crystallization and aggregation of proteins in aqueous solution

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137085

Influence of aggregation on immunogenicity of recombinant human Factor VIII in hemophilia A mice

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137085

Where disease pathogenesis meets protein formulation: renal deposition of immunoglobulin aggregates.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137085

Structural characterization and immunogenicity in wild-type and immune tolerant mice of degraded recombinant human interferon alpha2b.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137085

Detection and characterization of aggregates, prefibrillar amyloidogenic oligomers, and protofibrils using fluorescence spectroscopy

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137085

Need for new vaccine formulations and potential of particulate antigen and DNA delivery systems

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137085

New insights into the mechanisms of protein misfolding and aggregation in amyloidogenic diseases derived from pressure studies

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137085

Oxidative dimer formation is the critical rate-limiting step for Parkinson's disease alpha-synuclein fibrillogenesis

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137085

High hydrostatic pressure as a tool to study protein aggregation and amyloidosis

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137085

Pressure provides new insights into protein folding, dynamics and structure

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137085

Origin, result and measurement of USP "essentially free" inspection for visible contaminating particles

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137085

Neutralizing antiviral B cell responses

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137085

Molecular determinants of immunogenicity: the immunon model of immune response

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137085

Immunogenicity of papaya mosaic virus-like particles fused to a hepatitis C virus epitope: evidence for the critical function of multimerization.

14 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.160457

Role of aluminum-containing adjuvants in antigen internalization by dendritic cells in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.160457

Size-dependent immunogenicity: therapeutic and protective properties of nano-vaccines against tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.160457

Multistep aggregation pathway of human interleukin-1 receptor antagonist: kinetic, structural, and morphological characterization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.160457

Acid-induced aggregation of human monoclonal IgG1 and IgG2: molecular mechanism and the effect of solution composition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.160457

Tungsten-induced protein aggregation: solution behavior

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.160457

Nearest neighbor pattern classification

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.160457

Characterization of oligomeric species on the aggregation pathway of human lysozyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.160457

The effects of denaturants on protein conformation and behavior at air/solution interface

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.160457

Structural and functional changes in ultrasonicated bovine serum albumin solutions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.160457

Biophysical characterization of insoluble aggregates of a multi-domain protein: an insight into the role of the various domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.160457

Determinants of autoantibody induction by conjugated papillomavirus virus-like particles

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.160457

Qualification of FTIR spectroscopic method for protein secondary structural analysis

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137085

A Role for Protein Misfolding in Immunogenicity of Biopharmaceuticals

26 November 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.160457

Antibody Response to Aggregated Human Interferon Alpha2b in Wild-type and Transgenic Immune Tolerant Mice Depends on Type and Level of Aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.160457

Immunogenicity of aggregates of recombinant human growth hormone in mouse models

21 January 2018

1 reference

12 December 2020

Shaken, not stirred: mechanical stress testing of an IgG1 antibody

1 reference

12 December 2020

Analysis of DNA-protein interactions by intrinsic fluorescence

1 reference

12 December 2020

Effect of ions on agitation- and temperature-induced aggregation reactions of antibodies

1 reference

12 December 2020

Quantitation of protein particles in parenteral solutions using micro-flow imaging

1 reference

12 December 2020

Detection of IgG aggregation by a high throughput method based on extrinsic fluorescence

1 reference

12 December 2020

Native and Hydrophobically Modified Human Immunoglobulin G at the Air/Water Interface

1 reference

12 December 2020

Structural properties of monoclonal antibody aggregates induced by freeze-thawing and thermal stress

1 reference

12 December 2020

Protein aggregates seem to play a key role among the parameters influencing the antigenicity of interferon alpha (IFN-alpha) in normal and transgenic mice

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M110.160457

1 reference

13 October 2017

1 reference

13 October 2017

PubMed publication ID

21454532

1 reference