(Q30503489)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21778406%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

title

Pathway and mechanism of drug binding to G-protein-coupled receptors (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21778406%20AND%20SRC:MED&resulttype=core&format=json

G protein-coupled receptor

8 February 2020

main subject

0 references

author

David W. Borhani

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21778406%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Huafeng Xu

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21778406%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

1

Ron O Dror

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21778406%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

author name string

Albert C Pan

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21778406%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Daniel H Arlow

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21778406%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Paul Maragakis

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21778406%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Yibing Shan

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21778406%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

David E Shaw

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21778406%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

language of work or name

English

0 references

publication date

21 July 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21778406%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

8 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21778406%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

volume

108

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21778406%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

page(s)

13118-13123

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21778406%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

issue

32

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21778406%20AND%20SRC:MED&resulttype=core&format=json

All-atom empirical potential for molecular modeling and dynamics studies of proteins

8 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156183

How does a drug molecule find its target binding site?

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156183

Conserved Binding Mode of Human β 2 Adrenergic Receptor Inverse Agonists and Antagonist Revealed by X-ray Crystallography

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156183

Drug-target residence time: critical information for lead optimization.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156183

A lipid pathway for ligand binding is necessary for a cannabinoid G protein-coupled receptor

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156183

NMR spectroscopy brings invisible protein states into focus

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156183

The structure and function of G-protein-coupled receptors

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156183

Structure-based discovery of beta2-adrenergic receptor ligands

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156183

A ligand channel through the G protein coupled receptor opsin

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156183

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156183

Mechanism of fast peptide recognition by SH3 domains

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156183

Electrostatic funneling of substrate in mitochondrial inner membrane carriers

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156183

Structure of a beta1-adrenergic G-protein-coupled receptor

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156183

Binding of orthosteric ligands to the allosteric site of the M(2) muscarinic cholinergic receptor

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156183

High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156183

GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156183

Isothermal titration calorimetry in drug discovery

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156183

Ligand binding: molecular mechanics calculation of the streptavidin-biotin rupture force

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156183

Computer simulations of the diffusion of a substrate to an active site of an enzyme.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156183

Identification of cardiac beta-adrenergic receptors by (minus) [3H]alprenolol binding

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156183

Negative cooperativity among beta-adrenergic receptors in frog erythrocyte membranes

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156183

Fundamental difference between the molecular interactions of agonists and antagonists with the β-adrenergic receptor

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156183

Solubilization and characterization of the beta-adrenergic receptor binding sites of frog erythrocytes

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156183

Time-resolved structural studies of protein reaction dynamics: a smorgasbord of X-ray approaches.

20 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1104614108

Ligand entry and exit pathways in the beta2-adrenergic receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1104614108

Allosteric Modulation of G Protein–Coupled Receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1104614108

Observation of a dewetting transition in the collapse of the melittin tetramer

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1104614108

Measurement of the millisecond activation switch of G protein-coupled receptors in living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1104614108

Site-directed mutagenesis of the rat beta1-adrenoceptor. Involvement of Tyr356 (7.43) in (+/-)cyanopindolol but not (+/-)[125Iodo]cyanopindolol binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1104614108

Adrenergic ligand liposolubility in membranes. Direct assessment in a beta-adrenergic binding system

21 January 2018

1 reference

12 December 2020

Ligand binding with stopped-flow rapid mixing

1 reference

12 December 2020

Dewetting-controlled binding of ligands to hydrophobic pockets

1 reference

12 December 2020

Modification of the binding properties of muscarinic receptors by gallamine

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1104614108

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21778406%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21778406%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

1 reference