(Q30513464)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21885405%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

title

A computational model to predict the effects of class I anti-arrhythmic drugs on ventricular rhythms (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21885405%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

1 reference

4

1 reference

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12 February 2020

Natalia Trayanova

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21885405%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Crystal M Ripplinger

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21885405%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

author name string

Jonathan D Moreno

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21885405%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Z Iris Zhu

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21885405%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Pei-Chi Yang

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21885405%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Mao-Tsuen Jeng

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21885405%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Chaoyi Kang

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21885405%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Lianguo Wang

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21885405%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Jason D Bayer

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21885405%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

David J Christini

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21885405%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Robert S Kass

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21885405%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Colleen E Clancy

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21885405%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

language of work or name

English

0 references

publication date

1 August 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21885405%20AND%20SRC:MED&resulttype=core&format=json

Science Translational Medicine

12 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21885405%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

volume

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21885405%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

issue

98

1 reference

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12 February 2020

page(s)

98ra83

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21885405%20AND%20SRC:MED&resulttype=core&format=json

Transmural heterogeneity and remodeling of ventricular excitation-contraction coupling in human heart failure

12 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328405

Predicting drug-induced slowing of conduction and pro-arrhythmia: identifying the 'bad' sodium current blockers

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328405

New developments in atrial antiarrhythmic drug therapy

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328405

Transmural dispersion of repolarization in failing and nonfailing human ventricle

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328405

Specificities of atrial electrophysiology: Clues to a better understanding of cardiac function and the mechanisms of arrhythmias

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328405

Multiscale modelling of drug-induced effects on cardiac electrophysiological activity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328405

Is heart size a factor in ventricular fibrillation? Or how close are rabbit and human hearts?

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328405

Flecainide sensitivity of a Na channel long QT mutation shows an open-channel blocking mechanism for use-dependent block

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328405

State-dependent trapping of flecainide in the cardiac sodium channel

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328405

How to impose microscopic reversibility in complex reaction mechanisms

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328405

Common molecular determinants of flecainide and lidocaine block of heart Na+ channels: evidence from experiments with neutral and quaternary flecainide analogues

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328405

Channel openings are necessary but not sufficient for use-dependent block of cardiac Na(+) channels by flecainide: evidence from the analysis of disease-linked mutations

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328405

The rise of computational biology

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328405

Preferential block of late sodium current in the LQT3 DeltaKPQ mutant by the class I(C) antiarrhythmic flecainide.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328405

Slow conduction in cardiac tissue, I: effects of a reduction of excitability versus a reduction of electrical coupling on microconduction

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328405

Local anesthetics as effectors of allosteric gating. Lidocaine effects on inactivation-deficient rat skeletal muscle Na channels

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328405

Vulnerability in an excitable medium: analytical and numerical studies of initiating unidirectional propagation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328405

Mechanism of flecainide's rate-dependent actions on action potential duration in canine atrial tissue

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328405

On the molecular nature of the lidocaine receptor of cardiac Na+ channels. Modification of block by alterations in the alpha-subunit III-IV interdomain

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328405

Antiarrhythmic agents: the modulated receptor mechanism of action of sodium and calcium channel-blocking drugs

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328405

Effect of Flecainide on Action Potentials and Alternating Current-Induced Arrhythmias in Mammalian Myocardium

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328405

Effect of lidocaine on the electrophysiological properties of ventricular muscle and Purkinje fibers

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328405

Mechanisms of Action of Antiarrhythmic Drugs

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328405

Inhibition of ICa in single frog cardiac cells by quinidine, flecainide, ethmozin, and ethacizin

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328405

Preliminary report: effect of encainide and flecainide on mortality in a randomized trial of arrhythmia suppression after myocardial infarction

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328405

Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression Trial

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328405

The Cardiac Arrhythmia Suppression Trial: first CAST ... then CAST-II.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328405

Time- and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328405

Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3328405

The systems biology approach to drug development: application to toxicity assessment of cardiac drugs

28 July 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002588

Molecular pharmacology of the sodium channel mutation D1790G linked to the long-QT syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002588

Comparison of ventricular arrhythmia frequency in patients with ischemic cardiomyopathy versus nonischemic cardiomyopathy treated with implantable cardioverter defibrillators

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002588

Considerations in phase plane analysis for nonstationary reentrant cardiac behavior

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002588

Simulation study of cellular electric properties in heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002588

Alterations of K+ currents in isolated human ventricular myocytes from patients with terminal heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002588

Linking a genetic defect to its cellular phenotype in a cardiac arrhythmia

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002588

Flecainide inhibits the transient outward current in atrial myocytes isolated from the rabbit heart

21 January 2018

1 reference

12 December 2020

K+ channel blocking actions of flecainide compared with those of propafenone and quinidine in adult rat ventricular myocytes

1 reference

12 December 2020

Comparison of the effects of class I anti-arrhythmic drugs, cibenzoline, mexiletine and flecainide, on the delayed rectifier K+ current of guinea-pig ventricular myocytes

1 reference

12 December 2020

Ionic mechanisms of propagation in cardiac tissue. Roles of the sodium and L-type calcium currents during reduced excitability and decreased gap junction coupling

1 reference

12 December 2020

Alternans and spiral breakup in a human ventricular tissue model

1 reference

12 December 2020

Action potential propagation in inhomogeneous cardiac tissue: safety factor considerations and ionic mechanism

1 reference

12 December 2020

Circus movement in rabbit atrial muscle as a mechanism of trachycardia

1 reference

12 December 2020

Effects of flecainide on the cellular electrophysiology of neonatal and adult cardiac fibers

1 reference

12 December 2020

Two molecular transitions influence cardiac sodium channel gating

1 reference

12 December 2020

Effects of flecainide and quinidine on human atrial action potentials. Role of rate-dependence and comparison with guinea pig, rabbit, and dog tissues

1 reference

12 December 2020

Proarrhythmic response to sodium channel blockade. Theoretical model and numerical experiments

1 reference

12 December 2020

Differential block of cardiac delayed rectifier current by class Ic antiarrhythmic drugs: evidence for open channel block and unblock

1 reference

12 December 2020

10.1126/SCITRANSLMED.3002588

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21885405%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21885405%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

PubMed publication ID

21885405

1 reference