(Q40311694)

19 September 2017

title

Flecainide sensitivity of a Na channel long QT mutation shows an open-channel blocking mechanism for use-dependent block (English)

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19 September 2017

Yujie Zhu

1

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19 September 2017

John W Kyle

series ordinal

2

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19 September 2017

Peter J Lee

series ordinal

3

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19 September 2017

publication date

24 February 2006

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American Journal of Physiology Heart and Circulatory Physiology

19 September 2017

published in

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19 September 2017

volume

291

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19 September 2017

issue

1

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19 September 2017

page(s)

H29-37

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Molecular pharmacology of the sodium channel mutation D1790G linked to the long-QT syndrome

19 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01317.2005

Novel LQT-3 mutation affects Na+ channel activity through interactions between alpha- and beta1-subunits

21 January 2018

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Biophysical phenotypes of SCN5A mutations causing long QT and Brugada syndromes

21 January 2018

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Effects of flecainide in patients with new SCN5A mutation: mutation-specific therapy for long-QT syndrome?

21 January 2018

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Restoration of fast inactivation in an inactivation-defective human heart sodium channel by the cysteine modifying reagent benzyl-MTS: analysis of IFM-ICM mutation

21 January 2018

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Inherited and acquired vulnerability to ventricular arrhythmias: cardiac Na+ and K+ channels

21 January 2018

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Primary structure and functional expression of the human cardiac tetrodotoxin-insensitive voltage-dependent sodium channel

21 January 2018

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Block of wild-type and inactivation-deficient cardiac sodium channels IFM/QQQ stably expressed in mammalian cells

21 January 2018

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Effects of III-IV linker mutations on human heart Na+ channel inactivation gating

21 January 2018

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Movement of the Na+ channel inactivation gate during inactivation

21 January 2018

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Common molecular determinants of flecainide and lidocaine block of heart Na+ channels: evidence from experiments with neutral and quaternary flecainide analogues

21 January 2018

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Channel openings are necessary but not sufficient for use-dependent block of cardiac Na(+) channels by flecainide: evidence from the analysis of disease-linked mutations

21 January 2018

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A ubiquitous splice variant and a common polymorphism affect heterologous expression of recombinant human SCN5A heart sodium channels

21 January 2018

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Role of the C-terminal domain in inactivation of brain and cardiac sodium channels

21 January 2018

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The Na+ channel inactivation gate is a molecular complex: a novel role of the COOH-terminal domain.

21 January 2018

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Common molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltage-gated Na+ channels

21 January 2018

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State-dependent trapping of flecainide in the cardiac sodium channel

21 January 2018

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Slow inactivation in human cardiac sodium channels

21 January 2018

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Charge immobilization of the voltage sensor in domain IV is independent of sodium current inactivation

21 January 2018

1 reference

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The Na channel voltage sensor associated with inactivation is localized to the external charged residues of domain IV, S4.

21 January 2018

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Mechanisms of use-dependent block of sodium channels in excitable membranes by local anesthetics

21 January 2018

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21 January 2018

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Modulation of Cardiac Sodium Channel Gating by Protein Kinase A Can Be Altered by Disease-linked Mutation

21 January 2018

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The position of the fast-inactivation gate during lidocaine block of voltage-gated Na+ channels

21 January 2018

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Gating-dependent mechanisms for flecainide action in SCN5A-linked arrhythmia syndromes

21 January 2018

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SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome

21 January 2018

1 reference

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Arrhythmogenic mechanism of an LQT-3 mutation of the human heart Na(+) channel alpha-subunit: A computational analysis

21 January 2018

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A cluster of hydrophobic amino acid residues required for fast Na(+)-channel inactivation

21 January 2018

1 reference

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Molecular basis of charge movement in voltage-gated sodium channels

21 January 2018

1 reference

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10.1152/AJPHEART.01317.2005

21 January 2018

Identifiers

DOI

1 reference

19 September 2017

1 reference