(Q30634663)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25485684%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

title

Prostaglandin signaling suppresses beneficial microglial function in Alzheimer's disease models (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25485684%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

0 references

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25485684%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

author name string

Jenny U Johansson

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25485684%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

Qian Wang

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25485684%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

Maharshi Panchal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25485684%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

Xibin Liang

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25485684%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

Angel Trueba-Saiz

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25485684%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

Holden D Brown

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25485684%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

Siddhita D Mhatre

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25485684%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

Taylor Loui

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25485684%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

Katrin I Andreasson

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25485684%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

language of work or name

English

0 references

publication date

8 December 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25485684%20AND%20SRC:MED&resulttype=core&format=json

Journal of Clinical Investigation

24 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25485684%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

volume

125

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25485684%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25485684%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

page(s)

350-364

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25485684%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

24 February 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4382270/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes

14 July 2018

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Suppression of Alzheimer-associated inflammation by microglial prostaglandin-E2 EP4 receptor signaling.

14 July 2018

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Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration.

14 July 2018

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Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

14 July 2018

1 reference

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Suppression of inflammation with conditional deletion of the prostaglandin E2 EP2 receptor in macrophages and brain microglia

14 July 2018

1 reference

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Circadian clock NAD+ cycle drives mitochondrial oxidative metabolism in mice

14 July 2018

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Microglia: a new frontier for synaptic plasticity, learning and memory, and neurodegenerative disease research.

14 July 2018

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Response to comments on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models"

14 July 2018

1 reference

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Comment on "ApoE-Directed Therapeutics Rapidly Clear -Amyloid and Reverse Deficits in AD Mouse Models"

14 July 2018

1 reference

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Functional impairment of microglia coincides with Beta-amyloid deposition in mice with Alzheimer-like pathology

14 July 2018

1 reference

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Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers

14 July 2018

1 reference

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β-Catenin-dependent lysosomal targeting of internalized tumor necrosis factor-α suppresses caspase-8 activation in apoptosis-resistant colon cancer cells

14 July 2018

1 reference

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TREM2 Variants in Alzheimer's Disease

14 July 2018

1 reference

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Variant of TREM2 Associated with the Risk of Alzheimer's Disease

14 July 2018

1 reference

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Inflammatory prostaglandin E2 signaling in a mouse model of Alzheimer disease.

14 July 2018

1 reference

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Mechanisms underlying the rapid peroxisome proliferator-activated receptor-γ-mediated amyloid clearance and reversal of cognitive deficits in a murine model of Alzheimer's disease

14 July 2018

1 reference

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Clinical and biomarker changes in dominantly inherited Alzheimer's disease

14 July 2018

1 reference

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Neurotoxicity of amyloid β-protein: synaptic and network dysfunction

14 July 2018

1 reference

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Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

14 July 2018

1 reference

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The many faces of insulin-like peptide signalling in the brain

14 July 2018

1 reference

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The circadian clock and pathology of the ageing brain

14 July 2018

1 reference

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ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382270

Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer's mice hippocampus.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382270

PGE2 EP1 receptor exacerbated neurotoxicity in a mouse model of cerebral ischemia and Alzheimer's disease.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382270

The ageing systemic milieu negatively regulates neurogenesis and cognitive function.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382270

Postsynaptic degeneration as revealed by PSD-95 reduction occurs after advanced Aβ and tau pathology in transgenic mouse models of Alzheimer's disease

14 July 2018

1 reference

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Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

14 July 2018

1 reference

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Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

14 July 2018

1 reference

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Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382270

Decreased clearance of CNS beta-amyloid in Alzheimer's disease

14 July 2018

1 reference

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Suppressed accumulation of cerebral amyloid {beta} peptides in aged transgenic Alzheimer's disease mice by transplantation with wild-type or prostaglandin E2 receptor subtype 2-null bone marrow

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382270

The prostaglandin E2 E-prostanoid 4 receptor exerts anti-inflammatory effects in brain innate immunity

14 July 2018

1 reference

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Extending healthy life span--from yeast to humans

14 July 2018

1 reference

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Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382270

A functional role for adult hippocampal neurogenesis in spatial pattern separation

14 July 2018

1 reference

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Small molecule, non-peptide p75 ligands inhibit Abeta-induced neurodegeneration and synaptic impairment

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382270

Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382270

Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice

14 July 2018

1 reference

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ApoE promotes the proteolytic degradation of Abeta

14 July 2018

1 reference

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Protective effects of NSAIDs on the development of Alzheimer disease

14 July 2018

1 reference

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Motif module map reveals enforcement of aging by continual NF-kappaB activity

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382270

Drug insight: effects mediated by peroxisome proliferator-activated receptor-gamma in CNS disorders

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382270

The pharmacology, neuroanatomy and neurogenetics of one-trial object recognition in rodents.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382270

Onset and progression in inherited ALS determined by motor neurons and microglia

14 July 2018

1 reference

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Levels of CSF prostaglandin E2, cognitive decline, and survival in Alzheimer's disease.

14 July 2018

1 reference

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Microglial EP2 as a new target to increase amyloid beta phagocytosis and decrease amyloid beta-induced damage to neurons

14 July 2018

1 reference

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Alzheimer Disease in the US Population

14 July 2018

1 reference

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CD36 mediates the innate host response to beta-amyloid

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382270

Targeted gene disruption of the prostaglandin E2 EP2 receptor.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382270

Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382270

A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382270

LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382270

Risk of Alzheimer's disease and duration of NSAID use.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382270

Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiologic studies

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382270

Memantine rescues transient cognitive impairment caused by high-molecular-weight aβ oligomers but not the persistent impairment induced by low-molecular-weight oligomers.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382270

Layer V cortical neurons require microglial support for survival during postnatal development.

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382270

PPARγ/RXRα-induced and CD36-mediated microglial amyloid-β phagocytosis results in cognitive improvement in amyloid precursor protein/presenilin 1 mice.

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382270

Atorvastatin prevents hippocampal cell death, neuroinflammation and oxidative stress following amyloid-β(1-40) administration in mice: evidence for dissociation between cognitive deficits and neuronal damage

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382270

Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382270

Cycloxygenase-2 activity promotes cognitive deficits but not increased amyloid burden in a model of Alzheimer's disease in a sex-dimorphic pattern

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382270

Deletion of the prostaglandin E2 EP2 receptor reduces oxidative damage and amyloid burden in a model of Alzheimer's disease.

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382270

Ineffective phagocytosis of amyloid-beta by macrophages of Alzheimer's disease patients.

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382270

Episodic-like memory deficits in the APPswe/PS1dE9 mouse model of Alzheimer's disease: relationships to beta-amyloid deposition and neurotransmitter abnormalities

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382270

Targeted expression of Cre recombinase in macrophages and osteoclasts in transgenic mice.

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382270

Serum insulin-like growth factor I regulates brain amyloid-beta levels.

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382270

Nonsteroidal Antiinflammatory Drugs and the Risk of Alzheimer's Disease

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382270

Co-expression of multiple transgenes in mouse CNS: a comparison of strategies.

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382270

Loss of the presynaptic vesicle protein synaptophysin in hippocampus correlates with cognitive decline in Alzheimer disease.

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382270

The CD11b promoter directs high-level expression of reporter genes in macrophages in transgenic mice.

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4382270

Elevated CSF prostaglandin E2 levels in patients with probable AD

25 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25485684

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Salt-sensitive hypertension and reduced fertility in mice lacking the prostaglandin EP2 receptor

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25485684

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1172/JCI77487

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25485684%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25485684%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

PubMed publication ID

25485684

1 reference