(Q46518657)

English

Memantine rescues transient cognitive impairment caused by high-molecular-weight aβ oligomers but not the persistent impairment induced by low-molecular-weight oligomers.

scientific article published in June 2013

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scholarly article

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2 March 2020

Memantine rescues transient cognitive impairment caused by high-molecular-weight aβ oligomers but not the persistent impairment induced by low-molecular-weight oligomers (English)

1 reference

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2 March 2020

cognitive dysfunction

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Adriano Sebollela

10

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2 March 2020

Claudia P Figueiredo

1

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2 March 2020

Sérgio Teixeira Ferreira

12

object named as

Sergio T Ferreira

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2 March 2020

Fernanda De Felice

11

object named as

Fernanda G De Felice

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2 March 2020

William L. Klein

9

object named as

William L Klein

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2 March 2020

2

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Julia R Clarke

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2 March 2020

author name string

José Henrique Ledo

3

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2 March 2020

Carine V Costa

5

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2 March 2020

Helen M Melo

6

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2 March 2020

Axa P Mota-Sales

7

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2 March 2020

Leonardo M Saraiva

8

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2 March 2020

Felipe C Ribeiro

4

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2 March 2020

language of work or name

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publication date

1 June 2013

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2 March 2020

Journal of Neuroscience

1 reference

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2 March 2020

33

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2 March 2020

23

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2 March 2020

9626-9634

1 reference

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2 March 2020

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6619709/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Neurotoxicity and memory deficits induced by soluble low-molecular-weight amyloid-β1-42 oligomers are revealed in vivo by using a novel animal model.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23739959

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of NMDA receptors is necessary for the induction of associative long-term potentiation in area CA1 of the rat hippocampal slice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23739959

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Soluble protein oligomers as emerging toxins in Alzheimer's and other amyloid diseases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23739959

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid β-peptide oligomers stimulate RyR-mediated Ca2+ release inducing mitochondrial fragmentation in hippocampal neurons and prevent RyR-mediated dendritic spine remodeling produced by BDNF.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23739959

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plastic modifications induced by object recognition memory processing

1 reference

https://pubmed.ncbi.nlm.nih.gov/23739959

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term potentiation of NMDA receptor-mediated synaptic transmission in the hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/23739959

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/23739959

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid-beta peptide oligomers disrupt axonal transport through an NMDA receptor-dependent mechanism that is mediated by glycogen synthase kinase 3beta in primary cultured hippocampal neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23739959

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reactive oxygen species and synaptic plasticity in the aging hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/23739959

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1 reference

https://pubmed.ncbi.nlm.nih.gov/23739959

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Monoclonal antibodies that target pathological assemblies of Abeta.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23739959

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial bound hexokinase activity as a preventive antioxidant defense: steady-state ADP formation as a regulatory mechanism of membrane potential and reactive oxygen species generation in mitochondria.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23739959

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Memantine acts as a cholinergic stimulant in the mouse hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/23739959

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23739959

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The complex PrP(c)-Fyn couples human oligomeric Aβ with pathological tau changes in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23739959

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

1 reference

https://pubmed.ncbi.nlm.nih.gov/23739959

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Low doses of memantine disrupt memory in adult rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23739959

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23739959

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Soluble Aβ oligomers inhibit long-term potentiation through a mechanism involving excessive activation of extrasynaptic NR2B-containing NMDA receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/23739959

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

1 reference

https://pubmed.ncbi.nlm.nih.gov/23739959

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23739959

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A beta oligomers - a decade of discovery

1 reference

https://pubmed.ncbi.nlm.nih.gov/23739959

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Object recognition memory and the rodent hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/23739959

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

1 reference

https://pubmed.ncbi.nlm.nih.gov/23739959

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptic pathology of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23739959

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural classification of toxic amyloid oligomers

1 reference

https://pubmed.ncbi.nlm.nih.gov/23739959

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Memantine preferentially blocks extrasynaptic over synaptic NMDA receptor currents in hippocampal autapses

1 reference

https://pubmed.ncbi.nlm.nih.gov/23739959

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/23739959

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/23739959

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers

1 reference

https://pubmed.ncbi.nlm.nih.gov/23739959

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Folic Acid Plus α-Tocopherol Mitigates Amyloid-β-Induced Neurotoxicity through Modulation of Mitochondrial Complexes Activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/23739959

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-methyl-D-aspartate receptors are required for synaptic targeting of Alzheimer's toxic amyloid-β peptide oligomers

1 reference

https://pubmed.ncbi.nlm.nih.gov/23739959

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of cell-derived oligomers of Abeta in Alzheimer's disease and avenues for therapeutic intervention.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23739959

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Self-assembly of Abeta(1-42) into globular neurotoxins.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23739959

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of NMDA receptor trafficking by amyloid-beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/23739959

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lack of evidence for the efficacy of memantine in mild Alzheimer disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23739959

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cognitive effects of cell-derived and synthetically derived Aβ oligomers

1 reference

https://pubmed.ncbi.nlm.nih.gov/23739959

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/23739959

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamate toxicity in immature cortical neurons precedes development of glutamate receptor currents.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23739959

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracerebroventricular injections in mice. Some methodological refinements

1 reference

https://pubmed.ncbi.nlm.nih.gov/23739959

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine

1 reference

https://pubmed.ncbi.nlm.nih.gov/23739959

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function

1 reference

https://pubmed.ncbi.nlm.nih.gov/23739959

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of memantine in rats and mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23739959

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of D1/D5 dopamine receptors protects neurons from synapse dysfunction induced by amyloid-beta oligomers

1 reference

https://pubmed.ncbi.nlm.nih.gov/23739959

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Soluble Aβ oligomer production and toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/23739959

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective impairment of some forms of synaptic plasticity by oligomeric amyloid-β peptide in the mouse hippocampus: implication of extrasynaptic NMDA receptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23739959

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss

1 reference

https://pubmed.ncbi.nlm.nih.gov/23739959

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptic targeting by Alzheimer's-related amyloid beta oligomers.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23739959

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunoelectron microscopic study of synaptic pathology in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23739959

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: prevention by systemic passive immunization

1 reference

https://pubmed.ncbi.nlm.nih.gov/23739959

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid-β oligomers induce differential gene expression in adult human brain slices

1 reference

https://pubmed.ncbi.nlm.nih.gov/23739959

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23739959

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotoxicity of amyloid β-protein: synaptic and network dysfunction

1 reference

https://pubmed.ncbi.nlm.nih.gov/23739959

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An overlooked neurotoxic species in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23739959

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preventing Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23739959

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid-β triggers the release of neuronal hexokinase 1 from mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/23739959

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.0482-13.2013

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23739959%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23739959%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23739959%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

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