(Q37979641)

26 August 2017

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes (English)

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26 August 2017

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3

Bart De Strooper

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26 August 2017

Iryna Benilova

1

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26 August 2017

Eric Karran

series ordinal

2

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26 August 2017

language of work or name

English

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publication date

29 January 2012

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26 August 2017

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26 August 2017

15

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26 August 2017

3

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26 August 2017

349-357

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https://scigraph.springernature.com/pub.10.1038/nn.3028

26 August 2017

0 references

cites work

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12 December 2020

Induction of beta (A4)-amyloid in primates by injection of Alzheimer's disease brain homogenate. Comparison with transmission of spongiform encephalopathy.

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12 December 2020

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12 December 2020

Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

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12 December 2020

Neurotoxic protein oligomers--what you see is not always what you get.

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12 December 2020

The amyloid hypothesis for Alzheimer's disease: a critical reappraisal

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12 December 2020

The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanism

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12 December 2020

Morphology and toxicity of Abeta-(1-42) dimer derived from neuritic and vascular amyloid deposits of Alzheimer's disease.

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12 December 2020

Tau protein is required for amyloid {beta}-induced impairment of hippocampal long-term potentiation.

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12 December 2020

Cognitive effects of cell-derived and synthetically derived Aβ oligomers

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12 December 2020

Nucleation-dependent polymerization is an essential component of amyloid-mediated neuronal cell death.

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12 December 2020

Amyloid beta-protein fibrillogenesis. Detection of a protofibrillar intermediate.

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12 December 2020

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

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12 December 2020

Opinion: What is the role of protein aggregation in neurodegeneration?

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12 December 2020

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

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12 December 2020

Blood-borne amyloid-beta dimer correlates with clinical markers of Alzheimer's disease.

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12 December 2020

Generation and therapeutic efficacy of highly oligomer-specific beta-amyloid antibodies.

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12 December 2020

Copper-mediated amyloid-beta toxicity is associated with an intermolecular histidine bridge.

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12 December 2020

Sensitive ELISA detection of amyloid-beta protofibrils in biological samples

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12 December 2020

Solution state characterization of amyloid beta-derived diffusible ligands

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12 December 2020

Vaccination with soluble Abeta oligomers generates toxicity-neutralizing antibodies.

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12 December 2020

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

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12 December 2020

Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio

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12 December 2020

Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function

1 reference

12 December 2020

A causative link between the structure of aberrant protein oligomers and their toxicity.

1 reference

12 December 2020

Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

1 reference

12 December 2020

Anti-oligomeric Abeta single-chain variable domain antibody blocks Abeta-induced toxicity against human neuroblastoma cells

1 reference

12 December 2020

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

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12 December 2020

Clusterin (apoJ) Alters the Aggregation of Amyloid β-Peptide (Aβ1-42) and Forms Slowly Sedimenting Aβ Complexes That Cause Oxidative Stress

1 reference

12 December 2020

Direct in vivo intracellular selection of conformation-sensitive antibody domains targeting Alzheimer's amyloid-beta oligomers

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12 December 2020

Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils

1 reference

12 December 2020

Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis

1 reference

12 December 2020

The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation

1 reference

12 December 2020

Two distinct amyloid beta-protein (Abeta) assembly pathways leading to oligomers and fibrils identified by combined fluorescence correlation spectroscopy, morphology, and toxicity analyses

1 reference

12 December 2020

Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers

1 reference

12 December 2020

Human apoE isoforms differentially regulate brain amyloid-β peptide clearance

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12 December 2020

Amyloid beta-protein dimers rapidly form stable synaptotoxic protofibrils

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12 December 2020

Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration

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12 December 2020

Pyroglutamate formation influences solubility and amyloidogenicity of amyloid peptides

1 reference

12 December 2020

Aβ(1-42) inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3β.

1 reference

12 December 2020

Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake

1 reference

12 December 2020

Different conformations of amyloid beta induce neurotoxicity by distinct mechanisms in human cortical neurons.

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12 December 2020

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers

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12 December 2020

In vitro aging of beta-amyloid protein causes peptide aggregation and neurotoxicity

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12 December 2020

Spherical aggregates of beta-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3beta

1 reference

12 December 2020

An amyloid-beta protofibril-selective antibody prevents amyloid formation in a mouse model of Alzheimer's disease.

1 reference

12 December 2020

Peripheral Abeta subspecies as risk biomarkers of Alzheimer's disease

1 reference

12 December 2020

Transglutaminase induces protofibril-like amyloid beta-protein assemblies that are protease-resistant and inhibit long-term potentiation

1 reference

12 December 2020

Alzheimer's disease-type neuronal tau hyperphosphorylation induced by A beta oligomers

1 reference

12 December 2020

Stabilization of neurotoxic Alzheimer amyloid-beta oligomers by protein engineering

1 reference

12 December 2020

A general model of prion strains and their pathogenicity

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12 December 2020

Structure-neurotoxicity relationships of amyloid beta-protein oligomers

1 reference

12 December 2020

Extracellular phosphorylation of the amyloid β-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer's disease

1 reference

12 December 2020

Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease

1 reference

12 December 2020

Aggregation of secreted amyloid beta-protein into sodium dodecyl sulfate-stable oligomers in cell culture

1 reference

12 December 2020

Molecular basis for passive immunotherapy of Alzheimer's disease

1 reference

12 December 2020

Directed selection of a conformational antibody domain that prevents mature amyloid fibril formation by stabilizing Abeta protofibrils

1 reference

12 December 2020

Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Abeta assembly forms throughout life

1 reference

12 December 2020

Amyloid-beta-derived diffusible ligands cause impaired axonal transport of mitochondria in neurons

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12 December 2020

1 reference

12 December 2020

Prions: protein aggregation and infectious diseases

1 reference

12 December 2020

Ion mobility-mass spectrometry reveals a conformational conversion from random assembly to β-sheet in amyloid fibril formation

1 reference

12 December 2020

The monomer state of beta-amyloid: where the Alzheimer's disease protein meets physiology

1 reference

12 December 2020

NMDA receptor-dependent signaling pathways that underlie amyloid beta-protein disruption of LTP in the hippocampus

1 reference

12 December 2020

Observation of metastable Abeta amyloid protofibrils by atomic force microscopy

1 reference

12 December 2020

Monoclonal antibodies that target pathological assemblies of Abeta.

1 reference

12 December 2020

Isolation and characterization of patient-derived, toxic, high mass amyloid beta-protein (Abeta) assembly from Alzheimer disease brains.

1 reference

12 December 2020

Anti-ADDL antibodies differentially block oligomer binding to hippocampal neurons

1 reference

12 December 2020

Abeta oligomers cause localized Ca(2+) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines

1 reference

12 December 2020

Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide

1 reference

12 December 2020

Amyloid beta-protein monomer structure: a computational and experimental study.

1 reference

12 December 2020

Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers.

1 reference

12 December 2020

Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process

1 reference

12 December 2020

Distinct cerebrospinal fluid amyloid beta peptide signatures in sporadic and PSEN1 A431E-associated familial Alzheimer's disease

1 reference

12 December 2020

Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models

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12 December 2020

Amyloid-β forms fibrils by nucleated conformational conversion of oligomers

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12 December 2020

A specific amyloid-beta protein assembly in the brain impairs memory

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12 December 2020

High ability of apolipoprotein E4 to stabilize amyloid-β peptide oligomers, the pathological entities responsible for Alzheimer's disease.

1 reference

12 December 2020

G protein-coupled receptors, cholinergic dysfunction, and Abeta toxicity in Alzheimer's disease

1 reference

12 December 2020

Characteristics of Amyloid-Related Oligomers Revealed by Crystal Structures of Macrocyclic β-Sheet Mimics

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12 December 2020

The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

1 reference

12 December 2020

The presence of sodium dodecyl sulphate-stable Abeta dimers is strongly associated with Alzheimer-type dementia.

1 reference

12 December 2020

Characterisation of two antibodies to oligomeric Abeta and their use in ELISAs on human brain tissue homogenates.

1 reference

12 December 2020

In vitro peroxidase oxidation induces stable dimers of beta-amyloid (1-42) through dityrosine bridge formation

1 reference

12 December 2020

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

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12 December 2020

Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host

1 reference

12 December 2020

A monoclonal antibody against synthetic Aβ dimer assemblies neutralizes brain-derived synaptic plasticity-disrupting Aβ.

1 reference

12 December 2020

Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders

1 reference

12 December 2020

Amyloid beta induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation

1 reference

12 December 2020

Single-domain antibodies recognize selectively small oligomeric forms of amyloid beta, prevent Abeta-induced neurotoxicity and inhibit fibril formation

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12 December 2020

Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers

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12 December 2020

Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins

1 reference

12 December 2020

Amyloid-β annular protofibrils evade fibrillar fate in Alzheimer disease brain

1 reference

12 December 2020

Targeting amyloid-beta peptide (Abeta) oligomers by passive immunization with a conformation-selective monoclonal antibody improves learning and memory in Abeta precursor protein (APP) transgenic mice.

1 reference

12 December 2020

The regulation of glucose metabolism by HIF-1 mediates a neuroprotective response to amyloid beta peptide

1 reference

12 December 2020

Conformational Abs recognizing a generic amyloid fibril epitope

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12 December 2020

A new amyloid beta variant favoring oligomerization in Alzheimer's-type dementia.

1 reference

12 December 2020

Multimodal techniques for diagnosis and prognosis of Alzheimer's disease

1 reference

12 December 2020

Conformation-sensitive antibodies against alzheimer amyloid-beta by immunization with a thioredoxin-constrained B-cell epitope peptide

1 reference

12 December 2020

De novo induction of amyloid-β deposition in vivo.

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNN.3028

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NN.3028

1 reference

Dimensions Publication ID

26 August 2017

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1 reference