(Q34110227)

31 July 2017

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title

Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process (English)

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31 July 2017

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1

Bart De Strooper

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31 July 2017

publication date

1 April 2010

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31 July 2017

published in

Physiological Reviews

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31 July 2017

volume

90

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31 July 2017

issue

2

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31 July 2017

page(s)

465-494

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Frequent amyloid deposition without significant cognitive impairment among the elderly

31 July 2017

cites work

1 reference

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21 January 2018

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Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons

21 January 2018

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Proteolysis of non-phosphorylated and phosphorylated tau by thrombin

21 January 2018

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Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

21 January 2018

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Putative function of ADAM9, ADAM10, and ADAM17 as APP alpha-secretase

21 January 2018

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https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

MMP-2, -3 and -9 levels and activity are not related to Abeta load in the frontal cortex in Alzheimer's disease.

21 January 2018

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Adapting proteostasis for disease intervention

21 January 2018

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Tau-mediated neurodegeneration in Alzheimer's disease and related disorders

21 January 2018

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Role of the APP non-amyloidogenic signaling pathway and targeting alpha-secretase as an alternative drug target for treatment of Alzheimer's disease.

21 January 2018

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Antagonistic effects of beta-site amyloid precursor protein-cleaving enzymes 1 and 2 on beta-amyloid peptide production in cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Accumulation of aspartic acid421- and glutamic acid391-cleaved tau in neurofibrillary tangles correlates with progression in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Human amyloid-beta synthesis and clearance rates as measured in cerebrospinal fluid in vivo

21 January 2018

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https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site. Evidence for an allosteric mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

In vitro characterization of the presenilin-dependent gamma-secretase complex using a novel affinity ligand.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system

21 January 2018

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https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Familial Alzheimer's disease presenilin 1 mutations cause alterations in the conformation of presenilin and interactions with amyloid precursor protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Experimental traumatic brain injury in rats stimulates the expression, production and activity of Alzheimer's disease beta-secretase (BACE-1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Isoaspartate residues dramatically influence substrate recognition and turnover by proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Isoaspartate-containing amyloid precursor protein-derived peptides alter efficacy and specificity of potential beta-secretases

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

MicroRNA-298 and microRNA-328 regulate expression of mouse beta-amyloid precursor protein-converting enzyme 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

The GGA proteins: adaptors on the move

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Differential regulation of BACE1 promoter activity by nuclear factor-kappaB in neurons and glia upon exposure to beta-amyloid peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Early-onset autosomal dominant Alzheimer disease: prevalence, genetic heterogeneity, and mutation spectrum

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Maturation and pro-peptide cleavage of beta-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Glu(332) in the Nicastrin ectodomain is essential for gamma-secretase complex maturation but not for its activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Self-assembly of Abeta(1-42) into globular neurotoxins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Identification of a caspase-derived N-terminal tau fragment in cellular and animal Alzheimer's disease models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

The role of caspase cleavage of tau in Alzheimer disease neuropathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Processing of beta-secretase by furin and other members of the proprotein convertase family

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Translational regulation of BACE-1 expression in neuronal and non-neuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Loss-of-function presenilin mutations in Alzheimer disease. Talking Point on the role of presenilin mutations in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Amyloid precursor protein is not processed by furin, PACE 4, PC1/3, PC2, PC4 and PC5/6 of the furin family of proprotein processing enzymes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Deficiency of Aph1B/C-gamma-secretase disturbs Nrg1 cleavage and sensorimotor gating that can be reversed with antipsychotic treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Analysis of tau phosphorylation and truncation in a mouse model of human tauopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Apoptotic mechanisms in Alzheimer neurofibrillary degeneration: cause or effect?

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Mice lacking both presenilin genes exhibit early embryonic patterning defects

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Alzheimer's dementia by circulation disorders: when trees hide the forest.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Regulation of steady-state beta-amyloid levels in the brain by neprilysin and endothelin-converting enzyme but not angiotensin-converting enzyme.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Degradation of the Alzheimer's amyloid beta peptide by endothelin-converting enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Alzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Insulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD)

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Reconstitution of gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Plasminogen activator activity is inhibited while neuroserpin is up-regulated in the Alzheimer disease brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Degradation of the amyloid beta-protein by the novel mitochondrial peptidasome, PreP

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

The disulphide bonds in the catalytic domain of BACE are critical but not essential for amyloid precursor protein processing activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

A non-amyloidogenic function of BACE-2 in the secretory pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Membrane Topology and Nicastrin-enhanced Endoproteolysis of APH-1, a Component of the γ-Secretase Complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Truncated carboxyl-terminal fragments of beta-amyloid precursor protein are processed to amyloid beta-proteins 40 and 42.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Oxidative regulation of fatty acid-induced tau polymerization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Tau mutations cause frontotemporal dementias

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Post-translational modifications of tau protein in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

ADAM9 is involved in pathological retinal neovascularization

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Characterization of Alzheimer's beta -secretase protein BACE. A pepsin family member with unusual properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

BACE1 (beta-secretase) transgenic and knockout mice: identification of neurochemical deficits and behavioral changes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Presenilin-1 deficiency leads to loss of Cajal-Retzius neurons and cortical dysplasia similar to human type 2 lissencephaly

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Selective targeting of perivascular macrophages for clearance of beta-amyloid in cerebral amyloid angiopathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Deletion of tumor necrosis factor death receptor inhibits amyloid beta generation and prevents learning and memory deficits in Alzheimer's mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

GGA proteins mediate the recycling pathway of memapsin 2 (BACE).

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Alterations of the microRNA network cause neurodegenerative disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Mutations in APP have independent effects on Abeta and CTFgamma generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Effects of prolonged angiotensin-converting enzyme inhibitor treatment on amyloid beta-protein metabolism in mouse models of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Solution state characterization of amyloid beta-derived diffusible ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Alternative pathways for production of beta-amyloid peptides of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Inhibitors of cathepsin B improve memory and reduce beta-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant, beta-secretase site of the amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Early N-terminal changes and caspase-6 cleavage of tau in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Neurodegeneration caused by expression of human truncated tau leads to progressive neurobehavioural impairment in transgenic rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Angiotensin-converting enzyme degrades Alzheimer amyloid beta-peptide (A beta ); retards A beta aggregation, deposition, fibril formation; and inhibits cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Bace1 modulates myelination in the central and peripheral nervous system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Furin is an endogenous regulator of alpha-secretase associated APP processing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Metabolic regulation of brain Abeta by neprilysin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Enhanced clearance of Abeta in brain by sustaining the plasmin proteolysis cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie?

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Global hairpin folding of tau in solution

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Cystatin C modulates cerebral beta-amyloidosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Endoplasmic reticulum retention of the gamma-secretase complex component Pen2 by Rer1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Equimolar production of amyloid beta-protein and amyloid precursor protein intracellular domain from beta-carboxyl-terminal fragment by gamma-secretase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

APP processing and synaptic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

RNA stimulates aggregation of microtubule-associated protein tau into Alzheimer-like paired helical filaments

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

A genomic screen for modifiers of tauopathy identifies puromycin-sensitive aminopeptidase as an inhibitor of tau-induced neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Inducible expression of Tau repeat domain in cell models of tauopathy: aggregation is toxic to cells but can be reversed by inhibitor drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Biogenesis of gamma-secretase early in the secretory pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Effects of TNFalpha-converting enzyme inhibition on amyloid beta production and APP processing in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

BACE is degraded via the lysosomal pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Gamma-secretase inhibitor prevents Notch3 activation and reduces proliferation in human lung cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

The neuronal microRNA system

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Substrate-targeting gamma-secretase modulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Isolation, chemical characterization, and quantitation of A beta 3-pyroglutamyl peptide from neuritic plaques and vascular amyloid deposits.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Comparative analysis of amyloid-beta chemical structure and amyloid plaque morphology of transgenic mouse and Alzheimer's disease brains

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Expression of the Alzheimer protease BACE1 is suppressed via its 5'-untranslated region

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

ADAMs 10 and 17 represent differentially regulated components of a general shedding machinery for membrane proteins such as transforming growth factor alpha, L-selectin, and tumor necrosis factor alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Brain plasmin enhances APP alpha-cleavage and Abeta degradation and is reduced in Alzheimer's disease brains

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Secretion and intracellular generation of truncated Abeta in beta-site amyloid-beta precursor protein-cleaving enzyme expressing human neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Upregulation of tPA/plasminogen proteolytic system in the periphery of amyloid deposits in the Tg2576 mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

A specific amyloid-beta protein assembly in the brain impairs memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Characterization of Abeta11-40/42 peptide deposition in Alzheimer's disease and young Down's syndrome brains: implication of N-terminally truncated Abeta species in the pathogenesis of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Constitutive alpha-secretase cleavage of the beta-amyloid precursor protein in the furin-deficient LoVo cell line: involvement of the pro-hormone convertase 7 and the disintegrin metalloprotease ADAM10.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Human blood-brain barrier receptors for Alzheimer's amyloid-beta 1- 40. Asymmetrical binding, endocytosis, and transcytosis at the apical side of brain microvascular endothelial cell monolayer

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Amyloid beta-degrading cryptidases: insulin degrading enzyme, presequence peptidase, and neprilysin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Structural principles of tau and the paired helical filaments of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Coordinated Expression of β-Amyloid Precursor Protein and the Putative β-Secretase BACE and α-Secretase ADAM10 in Mouse and Human Brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Presenilins in memory, Alzheimer's disease, and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Lipids revert inert Abeta amyloid fibrils to neurotoxic protofibrils that affect learning in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Untangling tau hyperphosphorylation in drug design for neurodegenerative diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP Transgenic Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Abeta42 is essential for parenchymal and vascular amyloid deposition in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Staging the pathological assembly of truncated tau protein into paired helical filaments in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Cystatin C inhibits amyloid-beta deposition in Alzheimer's disease mouse models

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Complex translational regulation of BACE1 involves upstream AUGs and stimulatory elements within the 5' untranslated region

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Neprilysin and insulin-degrading enzyme levels are increased in Alzheimer disease in relation to disease severity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Amino-terminally truncated Abeta peptide species are the main component of cotton wool plaques

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

The potential for beta-structure in the repeat domain of tau protein determines aggregation, synaptic decay, neuronal loss, and coassembly with endogenous Tau in inducible mouse models of tauopathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Brain glucose hypometabolism and oxidative stress in preclinical Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Promotion of BACE1 mRNA alternative splicing reduces amyloid beta-peptide production

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Sites of tau important for aggregation populate {beta}-structure and bind to microtubules and polyanions

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Abeta42.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Accelerated filament formation from tau protein with specific FTDP-17 missense mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Activation of beta2-adrenergic receptor stimulates gamma-secretase activity and accelerates amyloid plaque formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Neurodegenerative lysosomal disorders: a continuum from development to late age.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Cdk5 is a key factor in tau aggregation and tangle formation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Cryoelectron microscopy structure of purified gamma-secretase at 12 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Direct and potent regulation of gamma-secretase by its lipid microenvironment

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Crystal structure of human BACE2 in complex with a hydroxyethylamine transition-state inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Endothelin-converting enzyme-2 is increased in Alzheimer's disease and up-regulated by Abeta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

The generation of a 17 kDa neurotoxic fragment: an alternative mechanism by which tau mediates beta-amyloid-induced neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

BACE (beta-secretase) modulates the processing of APLP2 in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

beta-amyloid is different in normal aging and in Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Beta-amyloid imaging and memory in non-demented individuals: evidence for preclinical Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Oligomerization of endogenous and synthetic amyloid beta-protein at nanomolar levels in cell culture and stabilization of monomer by Congo red.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Tau is a candidate gene for chromosome 17 frontotemporal dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Efficient inhibition of the Alzheimer's disease beta-secretase by membrane targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

The amyloid-beta precursor protein: integrating structure with biological function

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and beta-catenin nuclear signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Deamidation and isoaspartate formation in proteins: unwanted alterations or surreptitious signals?

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Amyloid beta-protein precursor juxtamembrane domain regulates specificity of gamma-secretase-dependent cleavages

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Differential utilization of upstream AUGs in the beta-secretase mRNA suggests that a shunting mechanism regulates translation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Transcriptional and translational regulation of BACE1 expression--implications for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Amyloid beta-protein assembly and Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Pyroglutamate-modified amyloid beta-peptides--AbetaN3(pE)--strongly affect cultured neuron and astrocyte survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Alzheimer's disease as proteolytic disorders: anabolism and catabolism of beta-amyloid

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Dominant and differential deposition of distinct beta-amyloid peptide species, A beta N3(pE), in senile plaques.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Amino- and carboxyl-terminal heterogeneity of beta-amyloid peptides deposited in human brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Somatostatin regulates brain amyloid beta peptide Abeta42 through modulation of proteolytic degradation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

First demonstration of cerebrospinal fluid and plasma A beta lowering with oral administration of a beta-site amyloid precursor protein-cleaving enzyme 1 inhibitor in nonhuman primates

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

In vivo beta-secretase 1 inhibition leads to brain Abeta lowering and increased alpha-secretase processing of amyloid precursor protein without effect on neuregulin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Structure of the catalytic pore of gamma-secretase probed by the accessibility of substituted cysteines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

The C-terminal PAL motif and transmembrane domain 9 of presenilin 1 are involved in the formation of the catalytic pore of the gamma-secretase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Active gamma-secretase complexes contain only one of each component

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Inhibition of glutaminyl cyclase prevents pGlu-Abeta formation after intracortical/hippocampal microinjection in vivo/in situ.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Glutaminyl cyclases unfold glutamyl cyclase activity under mild acid conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Tau-based treatment strategies in neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Effect of a dominant-negative form of ADAM10 in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Adipsin, a biomarker of gastrointestinal toxicity mediated by a functional gamma-secretase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Aminopeptidase A contributes to the N-terminal truncation of amyloid beta-peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Nicastrin functions as a gamma-secretase-substrate receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Skeletal and CNS defects in Presenilin-1-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Insights into the phosphoregulation of beta-secretase sorting signal by the VHS domain of GGA1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Biological significance of isoaspartate and its repair system

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Pathological activity of familial Alzheimer's disease-associated mutant presenilin can be executed by six different gamma-secretase complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Purification and cloning of amyloid precursor protein beta-secretase from human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Beta-amyloid precursor protein cleavage by a membrane-bound protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Neuronal localization of the TNFalpha converting enzyme (TACE) in brain tissue and its correlation to amyloid plaques

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Rer1p competes with APH-1 for binding to nicastrin and regulates gamma-secretase complex assembly in the early secretory pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Presenilin is required for activity and nuclear access of Notch in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Beta-galactoside alpha2,6-sialyltransferase I cleavage by BACE1 enhances the sialylation of soluble glycoproteins. A novel regulatory mechanism for alpha2,6-sialylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Serum cystatin C and the risk of Alzheimer disease in elderly men

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

gamma-Secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

The role of presenilin cofactors in the gamma-secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Oxidative stress increases expression and activity of BACE in NT2 neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

ADAM19 is tightly associated with constitutive Alzheimer's disease APP alpha-secretase in A172 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Processing of Notch and amyloid precursor protein by gamma-secretase is spatially distinct

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

APP substitutions V715F and L720P alter PS1 conformation and differentially affect Abeta and AICD generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

The orphan G protein-coupled receptor 3 modulates amyloid-beta peptide generation in neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Up-regulation of the alpha-secretase ADAM10 by retinoic acid receptors and acitretin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Structure and function of gamma-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Transmembrane domain 9 of presenilin determines the dynamic conformation of the catalytic site of gamma-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

ADAM10, the rate-limiting protease of regulated intramembrane proteolysis of Notch and other proteins, is processed by ADAMS-9, ADAMS-15, and the gamma-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Excitotoxin-induced neuronal degeneration and seizure are mediated by tissue plasminogen activator.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Dutch, Flemish, Italian, and Arctic mutations of APP and resistance of Abeta to physiologically relevant proteolytic degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Energy inhibition elevates beta-secretase levels and activity and is potentially amyloidogenic in APP transgenic mice: possible early events in Alzheimer's disease pathogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

The low density lipoprotein receptor-related protein (LRP) is a novel beta-secretase (BACE1) substrate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Demonstration of BACE (beta-secretase) phosphorylation and its interaction with GGA1 in cells by fluorescence-lifetime imaging microscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming beta structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

GGA1 is expressed in the human brain and affects the generation of amyloid beta-peptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Analysis of the gamma-secretase interactome and validation of its association with tetraspanin-enriched microdomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Presenilins: members of the gamma-secretase quartets, but part-time soloists too.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Phosphorylation regulates intracellular trafficking of beta-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Stepwise proteolysis liberates tau fragments that nucleate the Alzheimer-like aggregation of full-length tau in a neuronal cell model

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Increased beta-secretase activity and expression in rats following transient cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Mice lacking the metalloprotease-disintegrin MDC9 (ADAM9) have no evident major abnormalities during development or adult life.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Control of peripheral nerve myelination by the beta-secretase BACE1

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Degradative organelles containing mislocalized alpha-and beta-synuclein proliferate in presenilin-1 null neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Purification, pharmacological modulation, and biochemical characterization of interactors of endogenous human gamma-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

beta Subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

DAPT-induced intracellular accumulations of longer amyloid beta-proteins: further implications for the mechanism of intramembrane cleavage by gamma-secretase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Matrix metalloproteinase-9 degrades amyloid-beta fibrils in vitro and compact plaques in situ

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

BACE2 functions as an alternative alpha-secretase in cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

C-terminal truncation modulates both nucleation and extension phases of tau fibrillization

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Matrix metalloproteinases expressed by astrocytes mediate extracellular amyloid-beta peptide catabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Truncated tau at D421 is associated with neurodegeneration and tangle formation in the brain of Alzheimer transgenic models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Hypoxia-inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

gamma-Cleavage is dependent on zeta-cleavage during the proteolytic processing of amyloid precursor protein within its transmembrane domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Insulin-degrading enzyme is exported via an unconventional protein secretion pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Leaky scanning and reinitiation regulate BACE1 gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Truncated tau from sporadic Alzheimer's disease suffices to drive neurofibrillary degeneration in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Neurovascular mechanisms of Alzheimer's neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.00023.2009

10.1152/PHYSREV.00023.2009

21 January 2018

Identifiers

DOI

1 reference

31 July 2017

1 reference