(Q46330873)

21 December 2017

title

Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology (English)

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21 December 2017

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21 December 2017

Dirk Montag

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Dirk Montag

17

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author name string

Stephan Schilling

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21 December 2017

Ulrike Zeitschel

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21 December 2017

Torsten Hoffmann

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21 December 2017

Ulrich Heiser

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21 December 2017

Mike Francke

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21 December 2017

Astrid Kehlen

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21 December 2017

Max Holzer

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21 December 2017

Birgit Hutter-Paier

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21 December 2017

Manuela Prokesch

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21 December 2017

Manfred Windisch

10

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21 December 2017

Wolfgang Jagla

11

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21 December 2017

Dagmar Schlenzig

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21 December 2017

Christiane Lindner

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21 December 2017

Thomas Rudolph

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21 December 2017

Gunter Reuter

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Hans-Ulrich Demuth

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Steffen Rossner

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21 December 2017

language of work or name

English

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publication date

28 September 2008

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21 December 2017

published in

Nature Medicine

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21 December 2017

volume

14

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21 December 2017

page(s)

1106-1111

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21 December 2017

issue

10

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21 December 2017

https://scigraph.springernature.com/pub.10.1038/nm.1872

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cites work

Alzheimer's disease: the amyloid cascade hypothesis

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7 January 2021

Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

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Amyloid beta protein (A beta) deposition: A beta 42(43) precedes A beta 40 in Down syndrome

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7 January 2021

Dominant and differential deposition of distinct beta-amyloid peptide species, A beta N3(pE), in senile plaques.

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7 January 2021

Presenilin-1 mutations in Alzheimer's disease.

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7 January 2021

Amino- and carboxyl-terminal heterogeneity of beta-amyloid peptides deposited in human brain.

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7 January 2021

Relative abundance of Alzheimer A beta amyloid peptide variants in Alzheimer disease and normal aging

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7 January 2021

Characterization of Abeta11-40/42 peptide deposition in Alzheimer's disease and young Down's syndrome brains: implication of N-terminally truncated Abeta species in the pathogenesis of Alzheimer's disease.

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7 January 2021

Pyroglutamate-modified amyloid beta-peptides--AbetaN3(pE)--strongly affect cultured neuron and astrocyte survival

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7 January 2021

Alzheimer's disease as proteolytic disorders: anabolism and catabolism of beta-amyloid

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7 January 2021

On the seeding and oligomerization of pGlu-amyloid peptides (in vitro)

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7 January 2021

Amino-terminally truncated Abeta peptide species are the main component of cotton wool plaques

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7 January 2021

Glutaminyl cyclases unfold glutamyl cyclase activity under mild acid conditions

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7 January 2021

Inhibition of glutaminyl cyclase alters pyroglutamate formation in mammalian cells

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7 January 2021

Primary structure and functional expression of a glutaminyl cyclase

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7 January 2021

Evidence for tissue-specific forms of glutaminyl cyclase.

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7 January 2021

The first potent inhibitors for human glutaminyl cyclase: synthesis and structure-activity relationship.

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7 January 2021

Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease

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7 January 2021

beta-amyloid is different in normal aging and in Alzheimer disease.

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7 January 2021

Amino-terminal deletions enhance aggregation of beta-amyloid peptides in vitro

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7 January 2021

Amino-truncated beta-amyloid42 peptides in cerebrospinal fluid and prediction of progression of mild cognitive impairment

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7 January 2021

CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV

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7 January 2021

Investigation of N-terminal glutamate cyclization of recombinant monoclonal antibody in formulation development

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7 January 2021

Inhibition of glutaminyl cyclase prevents pGlu-Abeta formation after intracortical/hippocampal microinjection in vivo/in situ.

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7 January 2021

Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease.

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7 January 2021

Early formation of mature amyloid-beta protein deposits in a mutant APP transgenic model depends on levels of Abeta(1-42).

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7 January 2021

Chromosome 13 dementia syndromes as models of neurodegeneration

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7 January 2021

Familial Danish dementia: co-existence of Danish and Alzheimer amyloid subunits (ADan AND A{beta}) in the absence of compact plaques

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7 January 2021

Generation of amyloid beta peptide with pyroglutamate at position 3 in primary cortical neurons

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7 January 2021

The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer's disease.

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7 January 2021

Identifiers

DOI

10.1038/NM.1872

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21 December 2017

PubMed ID

18836460

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21 December 2017