(Q51808780)

English

Equimolar production of amyloid beta-protein and amyloid precursor protein intracellular domain from beta-carboxyl-terminal fragment by gamma-secretase.

scientific article published on 4 April 2006

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scholarly article

1 reference

Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/16595682

Equimolar production of amyloid beta-protein and amyloid precursor protein intracellular domain from beta-carboxyl-terminal fragment by gamma-secretase. (English)

1 reference

Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/16595682

author name string

Nobuto Kakuda

1

1 reference

Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/16595682

Satoru Funamoto

2

1 reference

Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/16595682

Sousuke Yagishita

3

1 reference

Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/16595682

Mako Takami

4

1 reference

Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/16595682

Satoko Osawa

5

1 reference

Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/16595682

Naoshi Dohmae

6

1 reference

Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/16595682

Yasuo Ihara

7

1 reference

Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/16595682

language of work or name

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publication date

4 April 2006

1 reference

Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/16595682

Journal of Biological Chemistry

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Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/16595682

281

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12 April 2018

http://europepmc.org/abstract/MED/16595682

14776-14786

1 reference

Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/16595682

21

1 reference

Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/16595682

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513453200

21 January 2018

Reconstitution of gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513453200

21 January 2018

The role of presenilin cofactors in the gamma-secretase complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513453200

21 January 2018

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513453200

21 January 2018

A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513453200

21 January 2018

Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513453200

21 January 2018

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513453200

21 January 2018

The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513453200

21 January 2018

Direct visualization of the gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein: association with Fe65 and translocation to the nucleus

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513453200

21 January 2018

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513453200

21 January 2018

Activation of GSK-3 and phosphorylation of CRMP2 in transgenic mice expressing APP intracellular domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513453200

21 January 2018

Potential Link between Amyloid β-Protein 42 and C-terminal Fragment γ 49–99 of β-Amyloid Precursor Protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513453200

21 January 2018

Truncated carboxyl-terminal fragments of beta-amyloid precursor protein are processed to amyloid beta-proteins 40 and 42.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513453200

21 January 2018

Proteolytic processing of the Alzheimer's disease amyloid precursor protein within its cytoplasmic domain by caspase-like proteases.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513453200

21 January 2018

Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513453200

21 January 2018

The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513453200

21 January 2018

The gamma -secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513453200

21 January 2018

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513453200

21 January 2018

Purification and characterization of the human gamma-secretase complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513453200

21 January 2018

DAPT-induced intracellular accumulations of longer amyloid beta-proteins: further implications for the mechanism of intramembrane cleavage by gamma-secretase.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513453200

21 January 2018

Development of Abeta terminal end-specific antibodies and sensitive ELISA for Abeta variant.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513453200

21 January 2018

A basic amino acid in the cytoplasmic domain of Alzheimer's beta-amyloid precursor protein (APP) is essential for cleavage of APP at the alpha-site.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513453200

21 January 2018

Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513453200

21 January 2018

Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513453200

21 January 2018

Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513453200

21 January 2018

Mutations in APP have independent effects on Abeta and CTFgamma generation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513453200

21 January 2018

Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513453200

21 January 2018

gamma-Cleavage is dependent on zeta-cleavage during the proteolytic processing of amyloid precursor protein within its transmembrane domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513453200

21 January 2018

Distinct mechanisms by mutant presenilin 1 and 2 leading to increased intracellular levels of amyloid beta-protein 42 in Chinese hamster ovary cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513453200

21 January 2018

Selective reconstitution and recovery of functional gamma-secretase complex on budded baculovirus particles

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513453200

21 January 2018

Identification of a new presenilin-dependent zeta-cleavage site within the transmembrane domain of amyloid precursor protein.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513453200

21 January 2018

Linear non-competitive inhibition of solubilized human gamma-secretase by pepstatin A methylester, L685458, sulfonamides, and benzodiazepines

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513453200

21 January 2018

Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513453200

21 January 2018

Complex N-linked glycosylated nicastrin associates with active gamma-secretase and undergoes tight cellular regulation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513453200

21 January 2018

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513453200

21 January 2018

Nicastrin: gatekeeper of the gamma-secretase complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513453200

21 January 2018

Familial Alzheimer's disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragment

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513453200

21 January 2018

Blocking the cleavage at midportion between gamma- and epsilon-sites remarkably suppresses the generation of amyloid beta-protein.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513453200

21 January 2018

Nicastrin functions as a gamma-secretase-substrate receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513453200

21 January 2018

A Novel γ-Secretase Assay Based on Detection of the Putative C-terminal Fragment-γ of Amyloid β Protein Precursor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513453200

21 January 2018

Identifiers

10.1074/JBC.M513453200

1 reference

Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/16595682

1 reference

Europe PubMed Central

12 April 2018

http://europepmc.org/abstract/MED/16595682

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