(Q28143624)

2

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George S. Robertson

3

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John P. Vaillancourt

4

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Yanxia Zhu

5

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JingQi Huang

6

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Andréa LeBlanc

7

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David Smith

8

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Michael Rigby

9

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Mark S. Shearman

10

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Earl E. Clarke

11

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Hui Zheng

12

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Leonardus H.T. Van Der Ploeg

13

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Salvatore C. Ruffolo

14

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Nancy A. Thornberry

15

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Steve Xanthoudakis

16

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Robert J. Zamboni

17

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Sophie Roy

18

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Donald W. Nicholson

Human ICE/CED-3 protease nomenclature

19

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language of work or name

English

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publication date

30 April 1999

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April 1999

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published in

Cell

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volume

97

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page(s)

395-406

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issue

3

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cites work

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Increased production of amyloid precursor protein provides a substrate for caspase-3 in dying motoneurons.

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Co-localization of the cysteine protease caspase-3 with apoptotic myocytes after in vivo myocardial ischemia and reperfusion in the rat

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The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion

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Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

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Generation of amyloid beta protein from its precursor is sequence specific

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Apoptosis-mediated neurotoxicity induced by beta-amyloid and PrP fragments.

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Inhibition of human caspases by peptide-based and macromolecular inhibitors

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The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway

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Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease

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Amyloid precursor protein metabolism in primary cell cultures of neurons, astrocytes, and microglia

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Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

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The four-vessel occlusion rat model: method for complete occlusion of vertebral arteries and control of collateral circulation

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Temporal profile of neuronal damage in a model of transient forebrain ischemia

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A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE)

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A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis

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The profile of soluble amyloid beta protein in cultured cell media. Detection and quantification of amyloid beta protein and variants by immunoprecipitation-mass spectrometry

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Elevation of neuronal expression of NAIP reduces ischemic damage in the rat hippocampus

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