(Q40106778)

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The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice.

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2 January 2020

The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice (English)

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2 January 2020

electrophysiology

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7

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Jochen Herms

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2 January 2020

author name string

Sabine Ring

1

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2 January 2020

Sascha W Weyer

2

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2 January 2020

Susanne B Kilian

3

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2 January 2020

Elaine Waldron

4

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2 January 2020

Claus U Pietrzik

5

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2 January 2020

Mikhail A Filippov

6

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2 January 2020

Christian Buchholz

8

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2 January 2020

Christopher B Eckman

9

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2 January 2020

Martin Korte

10

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2 January 2020

David P Wolfer

11

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2 January 2020

Ulrike C Müller

12

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2 January 2020

language of work or name

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publication date

1 July 2007

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2 January 2020

Journal of Neuroscience

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2 January 2020

27

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2 January 2020

7817-7826

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2 January 2020

29

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2 January 2020

Age-related cognitive deficits, impaired long-term potentiation and reduction in synaptic marker density in mice lacking the beta-amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic background changes the pattern of forebrain commissure defects in transgenic mice underexpressing the beta-amyloid-precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypersensitivity to seizures in beta-amyloid precursor protein deficient mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms contributing to the deficits in hippocampal synaptic plasticity in mice lacking amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

No hippocampal neuron or synaptic bouton loss in learning-impaired aged beta-amyloid precursor protein-null mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced cerebrospinal fluid levels of alpha-secretase-cleaved amyloid precursor protein in aged rats: correlation with spatial memory deficits

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Levels of alpha- and beta-secretase cleaved amyloid precursor protein in the cerebrospinal fluid of Alzheimer's disease patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[alpha]-Secretase ADAM10 as well as [alpha]APPs is reduced in platelets and CSF of Alzheimer disease patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cytoplasmic domain of the LDL receptor-related protein regulates multiple steps in APP processing

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

alpha- and beta-secretase: profound changes in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

APP processing and synaptic function

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired explorative behavior and neophobia in genetically modified mice lacking or overexpressing the extracellular serine protease inhibitor neuroserpin

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of Receptor-mediated Endocytosis Demonstrates Generation of Amyloid β-Protein at the Cell Surface

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A secreted form of the beta-amyloid precursor protein (sAPP695) improves spatial recognition memory in OF1 mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Soluble form of amyloid precursor protein regulates proliferation of progenitors in the adult subventricular zone.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FE65 constitutes the functional link between the low-density lipoprotein receptor-related protein and the amyloid precursor protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The amyloid-beta precursor protein: integrating structure with biological function

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synapse Formation and Function Is Modulated by the Amyloid Precursor Protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The amyloid precursor protein: beyond amyloid

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The functions of mammalian amyloid precursor protein and related amyloid precursor-like proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ADAM-10 over-expression increases cortical synaptogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

APL-1, a Caenorhabditis elegans protein related to the human beta-amyloid precursor protein, is essential for viability

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Secreted form of amyloid beta protein precursor is involved in the growth regulation of fibroblasts.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Behavioral symptoms in Alzheimer's disease: phenomenology and treatment.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased alpha-secretase-cleaved amyloid precursor protein as a diagnostic marker for Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Behavioral and anatomical deficits in mice homozygous for a modified beta-amyloid precursor protein gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that production and release of amyloid beta-protein involves the endocytic pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increase in extracellular NCAM and amyloid precursor protein following induction of long-term potentiation in the dentate gyrus of anaesthetized rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Generation of mice with a 200-kb amyloid precursor protein gene deletion by Cre recombinase-mediated site-specific recombination in embryonic stem cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cerebrospinal fluid levels of alpha-secretase-cleaved soluble amyloid precursor protein mirror cognition in a Swedish family with Alzheimer disease and a gene mutation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Secreted form of beta-amyloid precursor protein shifts the frequency dependency for induction of LTD, and enhances LTP in hippocampal slices.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurobehavioral development, adult openfield exploration and swimming navigation learning in mice with a modified beta-amyloid precursor protein gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Memory-enhancing effects of secreted forms of the beta-amyloid precursor protein in normal and amnestic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17634375

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.1026-07.2007

1 reference

Europe PubMed Central

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2 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17634375%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17634375%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

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