(Q44686140)

5 December 2017

BACE1 (beta-secretase) transgenic and knockout mice: identification of neurochemical deficits and behavioral changes (English)

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5 December 2017

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9

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5 December 2017

Steve M Harrison

1

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5 December 2017

Alex J Harper

2

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5 December 2017

Julie Hawkins

3

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5 December 2017

Graham Duddy

4

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5 December 2017

Evelyn Grau

5

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5 December 2017

Pippa L Pugh

6

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5 December 2017

Panida H Winter

7

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5 December 2017

Claire S Shilliam

8

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5 December 2017

Lee A Dawson

10

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5 December 2017

M Isabel Gonzalez

11

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5 December 2017

Neil Upton

12

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5 December 2017

Menelas N Pangalos

13

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5 December 2017

Colin Dingwall

14

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5 December 2017

language of work or name

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1 November 2003

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Molecular and Cellular Neuroscience

5 December 2017

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5 December 2017

24

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5 December 2017

3

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5 December 2017

646-655

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Tests for emotionality in rats and mice: A review

5 December 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900227-6

7 January 2021

Selective nicotinic receptor consequences in APP(SWE) transgenic mice.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900227-6

7 January 2021

Expression of human beta-secretase in the mouse brain increases the steady-state level of beta-amyloid.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900227-6

7 January 2021

Amyloid-associated neuron loss and gliogenesis in the neocortex of amyloid precursor protein transgenic mice.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900227-6

7 January 2021

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

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https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900227-6

7 January 2021

Cortical neurons immunoreactive with antisera against neuropeptide Y are altered in Alzheimer's-type dementia.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900227-6

7 January 2021

Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice.

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https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900227-6

7 January 2021

The role of serotonin in depression and anxiety

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https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900227-6

7 January 2021

Neuropeptides in hippocampus and cortex in transgenic mice overexpressing V717F beta-amyloid precursor protein--initial observations.

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https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900227-6

7 January 2021

Reconstitution of gamma-secretase activity

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https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900227-6

7 January 2021

Prospects for pharmacological intervention in Alzheimer disease

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https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900227-6

7 January 2021

Alzheimer disease: mouse models pave the way for therapeutic opportunities

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900227-6

7 January 2021

Pyramidal neurone modulation: a therapeutic target for Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900227-6

7 January 2021

Animal and drug modelling for Alzheimer synaptic pathology

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900227-6

7 January 2021

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

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https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900227-6

7 January 2021

Effects of agents which enhance GABA-mediated neurotransmission on licking conflict in rats and exploration in mice

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900227-6

7 January 2021

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900227-6

7 January 2021

Survival and plasticity of basal forebrain cholinergic systems in mice transgenic for presenilin-1 and amyloid precursor protein mutant genes

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900227-6

7 January 2021

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900227-6

7 January 2021

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900227-6

7 January 2021

Abeta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900227-6

7 January 2021

Transgenic mouse models of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900227-6

7 January 2021

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900227-6

7 January 2021

Progressive and gender-dependent cognitive impairment in the APP(SW) transgenic mouse model for Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900227-6

7 January 2021

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900227-6

7 January 2021

Coordinated Expression of β-Amyloid Precursor Protein and the Putative β-Secretase BACE and α-Secretase ADAM10 in Mouse and Human Brain

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900227-6

7 January 2021

Control of memory formation through regulated expression of a CaMKII transgene

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900227-6

7 January 2021

Serotonin in aging, late-life depression, and Alzheimer's disease: the emerging role of functional imaging.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900227-6

7 January 2021

Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900227-6

7 January 2021

High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900227-6

7 January 2021

Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900227-6

7 January 2021

Adaptation of the circular platform spatial memory task for mice: use in detecting cognitive impairment in the APP(SW) transgenic mouse model for Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900227-6

7 January 2021

Epileptogenesis and enhanced prepulse inhibition in GABA(B1)-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900227-6

7 January 2021

Acetylcholine and choline levels in post-mortem human brain tissue: preliminary observations in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900227-6

7 January 2021

Compartmentalization of beta-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900227-6

7 January 2021

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900227-6

7 January 2021

Behavioral and functional analysis of mouse phenotype: SHIRPA, a proposed protocol for comprehensive phenotype assessment

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900227-6

7 January 2021

Skeletal and CNS defects in Presenilin-1-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900227-6

7 January 2021

Amyloidogenic processing of the human amyloid precursor protein in primary cultures of rat hippocampal neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900227-6

7 January 2021

Purification and cloning of amyloid precursor protein beta-secretase from human brain

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900227-6

7 January 2021

Generalized lacZ expression with the ROSA26 Cre reporter strain

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900227-6

7 January 2021

Monoaminergic neurotransmitters, their precursors and metabolites in brains of Alzheimer patients

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900227-6

7 January 2021

Single and multiple transgenic mice as models for Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900227-6

7 January 2021

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900227-6

7 January 2021

Measurement of anxiety in transgenic mice.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900227-6

7 January 2021

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900227-6

7 January 2021

10.1016/S1044-7431(03)00227-6

Identifiers

DOI

1 reference

5 December 2017

1 reference