(Q33971296)

30 July 2017

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title

Transgenic mouse models of Alzheimer's disease. (English)

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30 July 2017

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C Janus

1

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30 July 2017

M A Chishti

series ordinal

2

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30 July 2017

D Westaway

series ordinal

3

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30 July 2017

language of work or name

English

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publication date

1 July 2000

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Biochimica et Biophysica Acta

30 July 2017

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30 July 2017

1502

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30 July 2017

1

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30 July 2017

63-75

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The molecular pathology of Alzheimer's disease

30 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Alpha-2 macroglobulin is genetically associated with Alzheimer disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Alzheimer's disease: the amyloid cascade hypothesis

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Preamyloid Deposits, Amyloid Deposits, and Senile Plaques in Alzheimer's Disease, Down Syndrome, and Aging

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Amyloid fibril toxicity in Alzheimer's disease and diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Age and damage induced changes in amyloid protein precursor immunohistochemistry in the rat brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Senescence-accelerated mouse. Neurochemical studies on aging.

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Visual-discrimination learning ability and beta-amyloid accumulation in the dog.

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Beta-amyloid accumulation correlates with cognitive dysfunction in the aged canine

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Senile plaques in cortex of aged normal monkeys.

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

The neural basis of memory decline in aged monkeys

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects.

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Rating of the lesions in senile dementia of the Alzheimer type: concordance between laboratories. A European multicenter study under the auspices of EURAGE.

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Tau mutations cause frontotemporal dementias.

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Genetics of mouse behavior: interactions with laboratory environment.

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Familial Alzheimer's disease-linked mutations at Val717 of amyloid precursor protein are specific for the increased secretion of A beta 42(43).

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Degeneration of skeletal muscle, peripheral nerves, and the central nervous system in transgenic mice overexpressing wild-type prion proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Transgenic mice expressing Alzheimer amyloid precursor proteins.

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

APP transgenesis: approaches toward the development of animal models for Alzheimer disease neuropathology

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Abeta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse.

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Chimeric prion protein expression in cultured cells and transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Genetic modification of the phenotypes produced by amyloid precursor protein overexpression in transgenic mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

APPSw transgenic mice develop age-related A beta deposits and neuropil abnormalities, but no neuronal loss in CA1.

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Expression in brain of amyloid precursor protein mutated in the alpha-secretase site causes disturbed behavior, neuronal degeneration and premature death in transgenic mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Expression of APP in transgenic mice: a comparison of neuron-specific promoters.

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

The Alzheimer's A beta peptide induces neurodegeneration and apoptotic cell death in transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Skeletal and CNS defects in Presenilin-1-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Effects of PS1 deficiency on membrane protein trafficking in neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid beta-protein 42 in the brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Abeta1-42/43 expression.

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins.

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Activation of microglial cells by beta-amyloid protein and interferon-gamma.

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Amyloidogenic role of cytokine TGF-beta1 in transgenic mice and in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition.

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Amyloid, the presenilins and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Alzheimer's disease: genotypes, phenotypes, and treatments

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Accumulation of amyloid precursor protein-like immunoreactivity in rat brain in response to thiamine deficiency.

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Beta-amyloid(1-40) effects on behavior and memory.

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

In vitro aggregation facilities beta-amyloid peptide-(25-35)-induced amnesia in the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Chronic cognitive deficits and amyloid precursor protein elevation after selective immunotoxin lesions of the basal forebrain cholinergic system.

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Delayed behavioral effects following intrahippocampal injection of aggregated A beta (1-42).

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

beta-Amyloid 25-35 and/or quinolinic acid injections into the basal forebrain of young male Fischer-344 rats: behavioral, neurochemical and histological effects.

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Alzheimer's disease: cell-specific pathology isolates the hippocampal formation

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Toward a representational hypothesis of the role of hippocampal synaptic plasticity in spatial and other forms of learning

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Aging and the physiology of spatial memory

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

The importance of comparative studies and ecological validity for understanding hippocampal structure and cognitive function

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

A synaptic model of memory: long-term potentiation in the hippocampus

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Hippocampal mossy fiber distribution covaries with open-field habituation in the mouse.

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Neurobehavioral development, adult openfield exploration and swimming navigation learning in mice with a modified beta-amyloid precursor protein gene

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Transgenic mice expressing an alpha-secretion mutant of the amyloid precursor protein in the brain develop a progressive CNS disorder.

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Reflex-ontogeny and behavioural development of the mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

A proposed test battery and constellations of specific behavioral paradigms to investigate the behavioral phenotypes of transgenic and knockout mice

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Cues for spontaneous alternation.

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Spatial localization does not require the presence of local cues

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Ontogenetic aspects of central cholinergic involvement in spontaneous alternation behavior.

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

T-maze alternation, response patterning, and septo-hippocampal circuitry in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

FVB/N: an inbred mouse strain preferable for transgenic analyses

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Assessment of learning by the Morris water task and fear conditioning in inbred mouse strains and F1 hybrids: implications of genetic background for single gene mutations and quantitative trait loci analyses.

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

NMDA-receptor-dependent synaptic plasticity: multiple forms and mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Long-term potentiation: what's learning got to do with it?

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Spatial learning without NMDA receptor-dependent long-term potentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Distinct components of spatial learning revealed by prior training and NMDA receptor blockade.

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Complex behavioral strategy and reversal learning in the water maze without NMDA receptor-dependent long-term potentiation.

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Memory and long-term potentiation (LTP) dissociated: normal spatial memory despite CA1 LTP elimination with Kv1.4 antisense

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: lack of association with amyloid deposits.

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Progressive and gender-dependent cognitive impairment in the APP(SW) transgenic mouse model for Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

A vector for expressing foreign genes in the brains and hearts of transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Neuron loss in APP transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

Severity of spatial learning impairment in aging: development of a learning index for performance in the Morris water maze.

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900033-8

7 January 2021

10.1016/S0925-4439(00)00033-8

Identifiers

DOI

1 reference

30 July 2017

1 reference