(Q48385872)

11 February 2018

title

Transgenic mice expressing an alpha-secretion mutant of the amyloid precursor protein in the brain develop a progressive CNS disorder. (English)

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11 February 2018

author name string

Moechars D

1

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11 February 2018

Lorent K

2

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11 February 2018

Dewachter I

3

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11 February 2018

Baekelandt V

4

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11 February 2018

De Strooper B

5

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11 February 2018

Van Leuven F

6

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11 February 2018

language of work or name

English

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publication date

1 September 1998

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11 February 2018

Behavioural Brain Research

published in

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11 February 2018

volume

95

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11 February 2018

issue

1

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11 February 2018

page(s)

55-64

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11 February 2018

Expression of APP in brains of transgenic mice containing the entire human APP gene.

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Introduction and expression of the 400 kilobase amyloid precursor protein gene in transgenic mice [corrected]

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Expression in brain of amyloid precursor protein mutated in the alpha-secretase site causes disturbed behavior, neuronal degeneration and premature death in transgenic mice.

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Transgenic mice for the amyloid precursor protein 695 isoform have impaired spatial memory

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7 January 2021

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

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7 January 2021

Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene.

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7 January 2021

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7 January 2021

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

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7 January 2021

Study of the synthesis and secretion of normal and artificial mutants of murine amyloid precursor protein (APP): cleavage of APP occurs in a late compartment of the default secretion pathway

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7 January 2021

Amyloidogenic processing of the human amyloid precursor protein in primary cultures of rat hippocampal neurons.

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7 January 2021

Amyloid beta-peptide is produced by cultured cells during normal metabolism

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7 January 2021

Production of the Alzheimer amyloid beta protein by normal proteolytic processing

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7 January 2021

Microwave antigen retrieval of β-amyloid precursor protein immunoreactivity

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7 January 2021

A simplified timm stain procedure compatible with formaldehyde fixation and routine paraffin embedding of rat brain

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7 January 2021

Effects of cerebellar vermal lesions on species-specific fear responses, neophobia, and taste-aversion learning in rats

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7 January 2021

Neurochemical lesion of the nucleus locus coeruleus increases neophobia in a specific exploration task but does not modify endocrine response to moderate stress

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Role of cyclic GMP in the regulation of neuronal calcium and survival by secreted forms of beta-amyloid precursor

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7 January 2021

Myoclonus, seizures, and paratonia in Alzheimer disease

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Clinical comparison of Alzheimer's disease in pedigrees with the codon 717 Val→Ile mutation in the amyloid precursor protein gene

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7 January 2021

Alternative excitotoxic hypotheses

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7 January 2021

Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?

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7 January 2021

Beta-amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage

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7 January 2021

Relationship of aggressive behavior to other neuropsychiatric symptoms in patients with Alzheimer's disease.

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7 January 2021

The spectrum of behavioral changes in Alzheimer's disease.

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7 January 2021

10.1016/S0166-4328(97)00210-6

Identifiers

DOI

1 reference

11 February 2018

PubMed ID

9754877

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11 February 2018