(Q48110123)

8 February 2018

title

Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death. (English)

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8 February 2018

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8

Dennis J Selkoe

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8 February 2018

Matthew Frosch

7

object named as

Matthew P Frosch

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8 February 2018

author name string

Malcolm A Leissring

1

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8 February 2018

Wesley Farris

2

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8 February 2018

Alice Y Chang

3

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8 February 2018

Dominic M Walsh

4

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8 February 2018

Xining Wu

5

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8 February 2018

Xiaoyan Sun

6

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8 February 2018

language of work or name

English

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publication date

1 December 2003

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8 February 2018

published in

Neuron

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8 February 2018

volume

40

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8 February 2018

page(s)

1087-1093

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8 February 2018

issue

6

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8 February 2018

Confirmation of association between D10S583 and Alzheimer's disease in a case--control sample.

cites work

1 reference

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7 January 2021

Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

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7 January 2021

Evidence for genetic linkage of Alzheimer's disease to chromosome 10q

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7 January 2021

Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease

1 reference

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7 January 2021

Alzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzyme

1 reference

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7 January 2021

Insulin degrading enzyme (IDE) genetic variants and risk of Alzheimer's disease: evidence of effect modification by apolipoprotein E (APOE).

1 reference

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7 January 2021

Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo

1 reference

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7 January 2021

A highly sensitive fluorometric assay for "enkephalinase," a neutral metalloendopeptidase that releases tyrosine-glycine-glycine from enkephalins

1 reference

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7 January 2021

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

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7 January 2021

Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss

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7 January 2021

Generation of antibodies specific for beta-amyloid by vaccination of patients with Alzheimer disease.

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7 January 2021

Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease.

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7 January 2021

Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models

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7 January 2021

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7 January 2021

Metabolic regulation of brain Abeta by neprilysin.

1 reference

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7 January 2021

Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease

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7 January 2021

Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes

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7 January 2021

Regional hypomyelination and dysplasia in transgenic mice with astrocyte-directed expression of interferon-gamma.

1 reference

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7 January 2021

Evidence that synaptically released beta-amyloid accumulates as extracellular deposits in the hippocampus of transgenic mice.

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7 January 2021

Kinetics of amyloid beta-protein degradation determined by novel fluorescence- and fluorescence polarization-based assays.

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7 January 2021

Neprilysin gene transfer reduces human amyloid pathology in transgenic mice.

1 reference

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7 January 2021

Control of memory formation through regulated expression of a CaMKII transgene

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7 January 2021

Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900787-6

7 January 2021

High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

1 reference

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7 January 2021

Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900787-6

7 January 2021

Genetic variation in a haplotype block spanningIDE influences Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900787-6

7 January 2021

Degradation of amyloid beta-protein by a metalloprotease secreted by microglia and other neural and non-neural cells

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900787-6

7 January 2021

Alzheimer's disease, neuropeptides, neuropeptidase, and amyloid-beta peptide metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900787-6

7 January 2021

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900787-6

7 January 2021

Clearing the brain's amyloid cobwebs

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900787-6

7 January 2021

Alzheimer's disease is a synaptic failure

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900787-6

7 January 2021

Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics

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7 January 2021

Overexpression of insulin degrading enzyme: cellular localization and effects on insulin signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900787-6

7 January 2021

The oligomerization of amyloid beta-protein begins intracellularly in cells derived from human brain

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900787-6

7 January 2021

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900787-6

7 January 2021

Amyloid-beta oligomers: their production, toxicity and therapeutic inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900787-6

7 January 2021

10.1016/S0896-6273(03)00787-6

Identifiers

DOI

1 reference

8 February 2018

PubMed ID

14687544

1 reference

8 February 2018