(Q39983829)

16 September 2017

title

Promotion of BACE1 mRNA alternative splicing reduces amyloid beta-peptide production (English)

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alternative mRNA splicing, via spliceosome

16 September 2017

main subject

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Karen R Mowrer

1

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16 September 2017

Michael S Wolfe

series ordinal

2

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16 September 2017

language of work or name

English

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publication date

8 May 2008

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Journal of Biological Chemistry

16 September 2017

published in

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16 September 2017

volume

283

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16 September 2017

issue

27

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16 September 2017

page(s)

18694-18701

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Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

16 September 2017

cites work

1 reference

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

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Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

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Purification and cloning of amyloid precursor protein beta-secretase from human brain

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Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

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Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

21 January 2018

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Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease

21 January 2018

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Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease

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21 January 2018

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Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease

21 January 2018

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Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients

21 January 2018

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Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

21 January 2018

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BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

21 January 2018

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BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

21 January 2018

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Control of peripheral nerve myelination by the beta-secretase BACE1

21 January 2018

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Bace1 modulates myelination in the central and peripheral nervous system.

21 January 2018

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BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions.

21 January 2018

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Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model

21 January 2018

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Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP Transgenic Mice

21 January 2018

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Memapsin 2 (beta-secretase) inhibitor drug, between fantasy and reality

21 January 2018

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A splice variant of beta-secretase deficient in the amyloidogenic processing of the amyloid precursor protein

21 January 2018

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Three novel alternatively spliced isoforms of the human beta-site amyloid precursor protein cleaving enzyme (BACE) and their effect on amyloid beta-peptide production

21 January 2018

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Splice variants of the beta-site APP-cleaving enzyme BACE1 in human brain and pancreas

21 January 2018

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Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

21 January 2018

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Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor

21 January 2018

1 reference

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A novel beta-site amyloid precursor protein cleaving enzyme (BACE) isoform regulated by nonsense-mediated mRNA decay and proteasome-dependent degradation

21 January 2018

1 reference

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Endoproteolysis of beta-secretase (beta-site amyloid precursor protein-cleaving enzyme) within its catalytic domain. A potential mechanism for regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801322200

Quantification and distribution of beta-secretase alternative splice variants in the rat and human brain

21 January 2018

1 reference

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Sequential assistance of molecular chaperones and transient formation of covalent complexes during protein degradation from the ER.

21 January 2018

1 reference

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BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M801322200

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16 September 2017

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