(Q40674796)

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Endoproteolysis of beta-secretase (beta-site amyloid precursor protein-cleaving enzyme) within its catalytic domain. A potential mechanism for regulation

scientific article published on 27 January 2003

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Europe PubMed Central

PubMed publication ID

22 September 2017

Endoproteolysis of beta-secretase (beta-site amyloid precursor protein-cleaving enzyme) within its catalytic domain. A potential mechanism for regulation (English)

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

author name string

Jason T Huse

1

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Damani Byant

2

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Yaxiong Yang

3

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Donald S Pijak

4

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Ian D'Souza

5

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

James J Lah

6

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Virginia M-Y Lee

7

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Robert W Doms

8

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

David G Cook

9

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Europe PubMed Central

PubMed publication ID

22 September 2017

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publication date

27 January 2003

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Europe PubMed Central

PubMed publication ID

22 September 2017

number of pages

9

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Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

22 September 2017

278

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Europe PubMed Central

PubMed publication ID

22 September 2017

19

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

17141-17149

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1 reference

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21 January 2018

Mutant genes in familial Alzheimer's disease and transgenic models

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21 January 2018

Translating cell biology into therapeutic advances in Alzheimer's disease

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A learning deficit related to age and beta-amyloid plaques in a mouse model of Alzheimer's disease

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21 January 2018

A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

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21 January 2018

A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

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21 January 2018

Cleavage of amyloid beta peptide during constitutive processing of its precursor

1 reference

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21 January 2018

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213303200

21 January 2018

Purification and cloning of amyloid precursor protein beta-secretase from human brain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213303200

21 January 2018

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213303200

21 January 2018

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213303200

21 January 2018

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213303200

21 January 2018

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213303200

21 January 2018

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

1 reference

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21 January 2018

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

1 reference

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21 January 2018

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

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21 January 2018

Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

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21 January 2018

Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the trans-golgi network

1 reference

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21 January 2018

Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213303200

21 January 2018

Evidence for phosphorylation and oligomeric assembly of presenilin 1.

1 reference

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21 January 2018

Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213303200

21 January 2018

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213303200

21 January 2018

Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213303200

21 January 2018

The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213303200

21 January 2018

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213303200

21 January 2018

Maturation and pro-peptide cleavage of beta-secretase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213303200

21 January 2018

Characterization of Alzheimer's beta -secretase protein BACE. A pepsin family member with unusual properties

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213303200

21 January 2018

A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta -secretase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213303200

21 January 2018

Processing of beta-secretase by furin and other members of the proprotein convertase family

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213303200

21 January 2018

Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213303200

21 January 2018

Phosphorylation regulates intracellular trafficking of beta-secretase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213303200

21 January 2018

Beta-secretase processing in the trans-Golgi network preferentially generates truncated amyloid species that accumulate in Alzheimer's disease brain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213303200

21 January 2018

The cytoplasmic domain mediates localization of furin to the trans-Golgi network en route to the endosomal/lysosomal system.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213303200

21 January 2018

Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213303200

21 January 2018

Novel beta-secretase cleavage of beta-amyloid precursor protein in the endoplasmic reticulum/intermediate compartment of NT2N cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213303200

21 January 2018

Serial passaging and differentiation of myogenic cells isolated from dystrophic mouse muscle

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213303200

21 January 2018

Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213303200

21 January 2018

Inactivation of lysosomal function in normal cultured human fibroblasts by chloroquine

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Antimalarials increase vesicle pH in Plasmodium falciparum

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Structure and pharmacology of the proton-ATPases

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21 January 2018

A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells

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21 January 2018

Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213303200

21 January 2018

Furin: a mammalian subtilisin/Kex2p-like endoprotease involved in processing of a wide variety of precursor proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213303200

21 January 2018

The versatility of proteolytic enzymes

1 reference

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21 January 2018

Molecular mechanisms for the conversion of zymogens to active proteolytic enzymes

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21 January 2018

ADAM, a novel family of membrane proteins containing A Disintegrin And Metalloprotease domain: multipotential functions in cell-cell and cell-matrix interactions

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21 January 2018

Metalloprotease-disintegrins: links to cell adhesion and cleavage of TNF alpha and Notch

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21 January 2018

Expression analysis of BACE2 in brain and peripheral tissues

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213303200

21 January 2018

Endoproteolytic processing and stabilization of wild-type and mutant presenilin

1 reference

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21 January 2018

Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation

1 reference

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21 January 2018

A splice variant of beta-secretase deficient in the amyloidogenic processing of the amyloid precursor protein

1 reference

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21 January 2018

Three novel alternatively spliced isoforms of the human beta-site amyloid precursor protein cleaving enzyme (BACE) and their effect on amyloid beta-peptide production

1 reference

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Splice variants of the beta-site APP-cleaving enzyme BACE1 in human brain and pancreas

1 reference

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21 January 2018

Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase

1 reference

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21 January 2018

The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213303200

21 January 2018

Endoproteolytic cleavage and proteasomal degradation of presenilin 2 in transfected cells

1 reference

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21 January 2018

Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease beta-secretase

1 reference

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Non-mammalian vertebrate pepsinogens and pepsins: isolation and characterization

1 reference

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21 January 2018

Identifiers

10.1074/JBC.M213303200

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

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