(Q24336570)

amyloid-beta metabolic process

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

P Paganetti

7

0 references

author name string

L Pastorino

1

0 references

A F Ikin

2

0 references

S Lamprianou

3

0 references

N Vacaresse

4

0 references

J P Revelli

5

0 references

K Platt

6

0 references

P M Mathews

8

0 references

S Harroch

9

0 references

J D Buxbaum

Molecular and Cellular Neuroscience

10

0 references

language of work or name

English

0 references

publication date

April 2004

0 references

published in

0 references

volume

25

0 references

issue

4

0 references

page(s)

642-9

0 references

cites work

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

1 reference

https://api.crossref.org/works/10.1016%2FJ.MCN.2003.12.013

7 January 2021

ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site

1 reference

https://api.crossref.org/works/10.1016%2FJ.MCN.2003.12.013

7 January 2021

The carboxyl-terminus of BACE contains a sorting signal that regulates BACE trafficking but not the formation of total A(beta).

1 reference

https://api.crossref.org/works/10.1016%2FJ.MCN.2003.12.013

7 January 2021

Continuing strategies for inhibiting Alzheimer's gamma-secretase.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MCN.2003.12.013

7 January 2021

Expression in mouse embryos and in adult mouse brain of three members of the amyloid precursor protein family, of the alpha-2-macroglobulin receptor/low density lipoprotein receptor-related protein and of its ligands apolipoprotein E, lipoprotein li

1 reference

https://api.crossref.org/works/10.1016%2FJ.MCN.2003.12.013

7 January 2021

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1 reference

https://api.crossref.org/works/10.1016%2FJ.MCN.2003.12.013

7 January 2021

Immunohistochemical and in situ analysis of amyloid precursor-like protein-1 and amyloid precursor-like protein-2 expression in Alzheimer disease and aged control brains

1 reference

https://api.crossref.org/works/10.1016%2FJ.MCN.2003.12.013

7 January 2021

Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FJ.MCN.2003.12.013

7 January 2021

Normal brain development in PS1 hypomorphic mice with markedly reduced gamma-secretase cleavage of betaAPP.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MCN.2003.12.013

7 January 2021

Emerging Alzheimer's disease therapies: inhibition of beta-secretase

1 reference

https://api.crossref.org/works/10.1016%2FJ.MCN.2003.12.013

7 January 2021

Abeta-generating enzymes: recent advances in beta- and gamma-secretase research

1 reference

https://api.crossref.org/works/10.1016%2FJ.MCN.2003.12.013

7 January 2021

Molecular cloning of the cDNA for a human amyloid precursor protein homolog: evidence for a multigene family

1 reference

https://api.crossref.org/works/10.1016%2FJ.MCN.2003.12.013

7 January 2021

Glu11 site cleavage and N-terminally truncated A beta production upon BACE overexpression

1 reference

https://api.crossref.org/works/10.1016%2FJ.MCN.2003.12.013

7 January 2021

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1016%2FJ.MCN.2003.12.013

7 January 2021

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FJ.MCN.2003.12.013

7 January 2021

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

1 reference

https://api.crossref.org/works/10.1016%2FJ.MCN.2003.12.013

7 January 2021

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

1 reference

https://api.crossref.org/works/10.1016%2FJ.MCN.2003.12.013

7 January 2021

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

1 reference

https://api.crossref.org/works/10.1016%2FJ.MCN.2003.12.013

7 January 2021

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

1 reference

https://api.crossref.org/works/10.1016%2FJ.MCN.2003.12.013

7 January 2021

Purification and cloning of amyloid precursor protein beta-secretase from human brain

1 reference

https://api.crossref.org/works/10.1016%2FJ.MCN.2003.12.013

7 January 2021

Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid beta protein precursor

1 reference

https://api.crossref.org/works/10.1016%2FJ.MCN.2003.12.013

7 January 2021

A critical role for the protein tyrosine phosphatase receptor type Z in functional recovery from demyelinating lesions

1 reference

https://api.crossref.org/works/10.1016%2FJ.MCN.2003.12.013

7 January 2021

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FJ.MCN.2003.12.013

7 January 2021

It all sticks together--the APP-related family of proteins and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FJ.MCN.2003.12.013

7 January 2021

Expression of human beta-secretase in the mouse brain increases the steady-state level of beta-amyloid.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MCN.2003.12.013

7 January 2021

BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FJ.MCN.2003.12.013

7 January 2021

Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor

1 reference

https://api.crossref.org/works/10.1016%2FJ.MCN.2003.12.013

7 January 2021

In search of gamma-secretase: presenilin at the cutting edge

1 reference

https://api.crossref.org/works/10.1016%2FJ.MCN.2003.12.013

7 January 2021

Amino-terminal Deletions Enhance Aggregation of β-Amyloid Peptides in Vitro

1 reference

https://api.crossref.org/works/10.1016%2FJ.MCN.2003.12.013

7 January 2021

The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation

1 reference

https://api.crossref.org/works/10.1016%2FJ.MCN.2003.12.013

7 January 2021

Expression analysis of BACE2 in brain and peripheral tissues

1 reference

https://api.crossref.org/works/10.1016%2FJ.MCN.2003.12.013

7 January 2021

Beta-secretase processing in the trans-Golgi network preferentially generates truncated amyloid species that accumulate in Alzheimer's disease brain

1 reference

https://api.crossref.org/works/10.1016%2FJ.MCN.2003.12.013

7 January 2021

Processing of beta-amyloid precursor-like protein-1 and -2 by gamma-secretase regulates transcription

1 reference

https://api.crossref.org/works/10.1016%2FJ.MCN.2003.12.013

7 January 2021

Secretion and intracellular generation of truncated Abeta in beta-site amyloid-beta precursor protein-cleaving enzyme expressing human neurons

1 reference

https://api.crossref.org/works/10.1016%2FJ.MCN.2003.12.013

7 January 2021

BACE1- and BACE2-expressing human cells: characterization of beta-amyloid precursor protein-derived catabolites, design of a novel fluorimetric assay, and identification of new in vitro inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FJ.MCN.2003.12.013

7 January 2021

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

1 reference

https://api.crossref.org/works/10.1016%2FJ.MCN.2003.12.013

7 January 2021

Human amyloid precursor-like protein 1--cDNA cloning, ectopic expression in COS-7 cells and identification of soluble forms in the cerebrospinal fluid

1 reference

https://api.crossref.org/works/10.1016%2FJ.MCN.2003.12.013

7 January 2021

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

1 reference

https://api.crossref.org/works/10.1016%2FJ.MCN.2003.12.013

7 January 2021

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

https://api.crossref.org/works/10.1016%2FJ.MCN.2003.12.013

7 January 2021

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

1 reference

https://api.crossref.org/works/10.1016%2FJ.MCN.2003.12.013

7 January 2021

Survival of cultured neurons from amyloid precursor protein knock-out mice against Alzheimer's amyloid-beta toxicity and oxidative stress.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MCN.2003.12.013

7 January 2021

Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MCN.2003.12.013

7 January 2021

Construction of gene targeting vectors from lambda KOS genomic libraries

1 reference

https://api.crossref.org/works/10.1016%2FJ.MCN.2003.12.013

7 January 2021