(Q43862564)

27 November 2017

title

Normal brain development in PS1 hypomorphic mice with markedly reduced gamma-secretase cleavage of betaAPP. (English)

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27 November 2017

R Rozmahel

1

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27 November 2017

J Huang

2

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27 November 2017

F Chen

3

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27 November 2017

Y Liang

4

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27 November 2017

V Nguyen

5

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27 November 2017

M Ikeda

6

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27 November 2017

G Levesque

7

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27 November 2017

G Yu

8

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27 November 2017

M Nishimura

9

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27 November 2017

P Mathews

10

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27 November 2017

S D Schmidt

11

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27 November 2017

M Mercken

12

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27 November 2017

C Bergeron

13

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27 November 2017

D Westaway

14

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27 November 2017

P St George-Hyslop

15

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27 November 2017

publication date

1 March 2002

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27 November 2017

published in

Neurobiology of Aging

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27 November 2017

volume

23

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27 November 2017

issue

2

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27 November 2017

page(s)

187-194

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Alpha-secretase-derived product of beta-amyloid precursor protein is decreased by presenilin 1 mutations linked to familial Alzheimer's disease.

27 November 2017

cites work

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https://api.crossref.org/works/10.1016%2FS0197-4580%2801%2900267-6

7 January 2021

Notch signaling: cell fate control and signal integration in development

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7 January 2021

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

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https://api.crossref.org/works/10.1016%2FS0197-4580%2801%2900267-6

7 January 2021

Requirement of the paraxis gene for somite formation and musculoskeletal patterning

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https://api.crossref.org/works/10.1016%2FS0197-4580%2801%2900267-6

7 January 2021

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

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https://api.crossref.org/works/10.1016%2FS0197-4580%2801%2900267-6

7 January 2021

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2801%2900267-6

7 January 2021

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

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https://api.crossref.org/works/10.1016%2FS0197-4580%2801%2900267-6

7 January 2021

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

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7 January 2021

Maintenance of somite borders in mice requires the Delta homologue DII1.

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7 January 2021

Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1.

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7 January 2021

The mouse pudgy mutation disrupts Delta homologue Dll3 and initiation of early somite boundaries

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7 January 2021

Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

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7 January 2021

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

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7 January 2021

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

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7 January 2021

Derivation of completely cell culture-derived mice from early-passage embryonic stem cells

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7 January 2021

Turnover of amyloid beta-protein in mouse brain and acute reduction of its level by phorbol ester.

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https://api.crossref.org/works/10.1016%2FS0197-4580%2801%2900267-6

7 January 2021

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2801%2900267-6

7 January 2021

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

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https://api.crossref.org/works/10.1016%2FS0197-4580%2801%2900267-6

7 January 2021

Skeletal and CNS defects in Presenilin-1-deficient mice

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https://api.crossref.org/works/10.1016%2FS0197-4580%2801%2900267-6

7 January 2021

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS0197-4580%2801%2900267-6

7 January 2021

Notch1 is essential for postimplantation development in mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2801%2900267-6

7 January 2021

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2801%2900267-6

7 January 2021

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2801%2900267-6

7 January 2021

10.1016/S0197-4580(01)00267-6

Identifiers

DOI

1 reference

27 November 2017

1 reference