(Q24304445)

negative regulation of amyloid precursor protein biosynthetic process

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

Guriqbal Basi

1

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Normand Frigon

2

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Robin Barbour

3

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Tam Doan

4

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Grace Gordon

5

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Lisa McConlogue

6

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Sukanto Sinha

7

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Michelle Zeller

Journal of Biological Chemistry

8

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language of work or name

English

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publication date

22 August 2003

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published in

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volume

278

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issue

34

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page(s)

31512-20

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cites work

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ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site

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Splice variants of the beta-site APP-cleaving enzyme BACE1 in human brain and pancreas

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The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the down critical region

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RNAi in human cells: basic structural and functional features of small interfering RNA.

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Subsite specificity of memapsin 2 (beta-secretase): implications for inhibitor design.

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APP transgenic mice Tg2576 accumulate Abeta peptides that are distinct from the chemically modified and insoluble peptides deposited in Alzheimer's disease senile plaques.

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Glu11 site cleavage and N-terminally truncated A beta production upon BACE overexpression

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Specificity of memapsin 1 and its implications on the design of memapsin 2 (beta-secretase) inhibitor selectivity

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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

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Secretion of beta-amyloid precursor protein cleaved at the amino terminus of the beta-amyloid peptide

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Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

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Alzheimer's disease. A firm base for drug development.

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Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

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BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

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Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

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Purification and cloning of amyloid precursor protein beta-secretase from human brain

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Erratum: Biochemical networking contributes more to genetic buffering in human and mouse metabolic pathways than does gene duplication

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RNA interference: listening to the sound of silence

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A non-amyloidogenic function of BACE-2 in the secretory pathway

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Stable suppression of gene expression by RNAi in mammalian cells

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Short RNA duplexes produced by hydrolysis with Escherichia coli RNase III mediate effective RNA interference in mammalian cells

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BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein

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Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems

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Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues.

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Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells

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Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease

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Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

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7 January 2021

The profile of soluble amyloid beta protein in cultured cell media. Detection and quantification of amyloid beta protein and variants by immunoprecipitation-mass spectrometry

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Expression analysis of BACE2 in brain and peripheral tissues

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7 January 2021

Maturation and pro-peptide cleavage of beta-secretase

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Processing of beta-secretase by furin and other members of the proprotein convertase family

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7 January 2021

Phosphorylation regulates intracellular trafficking of beta-secretase

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https://api.crossref.org/works/10.1074%2FJBC.M300169200

7 January 2021

BACE2 functions as an alternative alpha-secretase in cells

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https://api.crossref.org/works/10.1074%2FJBC.M300169200

7 January 2021

Substrate and inhibitor profile of BACE (beta-secretase) and comparison with other mammalian aspartic proteases

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7 January 2021

Beta-secretase processing in the trans-Golgi network preferentially generates truncated amyloid species that accumulate in Alzheimer's disease brain

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https://api.crossref.org/works/10.1074%2FJBC.M300169200

7 January 2021

Secretion and intracellular generation of truncated Abeta in beta-site amyloid-beta precursor protein-cleaving enzyme expressing human neurons

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https://api.crossref.org/works/10.1074%2FJBC.M300169200

7 January 2021

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

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https://api.crossref.org/works/10.1074%2FJBC.M300169200

7 January 2021

RNA interference--2001.

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https://api.crossref.org/works/10.1074%2FJBC.M300169200

7 January 2021

A system for stable expression of short interfering RNAs in mammalian cells

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https://api.crossref.org/works/10.1074%2FJBC.M300169200

7 January 2021

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

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https://api.crossref.org/works/10.1074%2FJBC.M300169200

7 January 2021

Deciphering the genetic basis of Alzheimer's disease

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7 January 2021

The beta-secretase, BACE: a prime drug target for Alzheimer's disease

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7 January 2021