(Q31032457)

28 June 2017

Substrate and inhibitor profile of BACE (beta-secretase) and comparison with other mammalian aspartic proteases (English)

1 reference

28 June 2017

Fiona Grüninger-Leitch

1

1 reference

28 June 2017

Daniel Schlatter

2

1 reference

28 June 2017

Erich Küng

3

1 reference

28 June 2017

Peter Nelböck

4

1 reference

28 June 2017

Heinz Döbeli

5

1 reference

28 June 2017

language of work or name

English

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publication date

7 December 2001

1 reference

Journal of Biological Chemistry

28 June 2017

1 reference

28 June 2017

277

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28 June 2017

7

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28 June 2017

4687-4693

1 reference

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

28 June 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109266200

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109266200

Purification and cloning of amyloid precursor protein beta-secretase from human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109266200

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109266200

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109266200

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109266200

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109266200

BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109266200

ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109266200

The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the down critical region

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109266200

Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109266200

Expression analysis of BACE2 in brain and peripheral tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109266200

Recombinant human renin produced in different expression systems: biochemical properties and 3D structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109266200

Purification and characterization of active recombinant human napsin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109266200

Identification of beta-secretase-like activity using a mass spectrometry-based assay system

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109266200

Characterization of Alzheimer's beta -secretase protein BACE. A pepsin family member with unusual properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109266200

A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta -secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109266200

Processing of beta-secretase by furin and other members of the proprotein convertase family

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109266200

Maturation and pro-peptide cleavage of beta-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109266200

Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109266200

The pro domain of beta-secretase does not confer strict zymogen-like properties but does assist proper folding of the protease domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109266200

Rapid identification of substrates for novel proteases using a combinatorial peptide library

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109266200

Mechanism of Inhibition of beta-site amyloid precursor protein-cleaving enzyme (BACE) by a statine-based peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109266200

The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta -amyloid precursor protein (APP) substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109266200

BACE2 functions as an alternative alpha-secretase in cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109266200

21 January 2018

Identifiers

DOI

10.1074/JBC.M109266200

1 reference

28 June 2017

1 reference