(Q24291471)

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The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta -amyloid precursor protein (APP) substrate

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The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta -amyloid precursor protein (APP) substrate (English)

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Alzheimer's disease

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based on heuristic

inferred from title

transmembrane protein

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Beta-secretase 1

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GOA release 2020-03-11

4

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author name string

R Yan

1

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P Han

2

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H Miao

3

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H Xu

5

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language of work or name

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publication date

28 September 2001

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Journal of Biological Chemistry

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276

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39

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36788-96

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Targeting and retention of Golgi membrane proteins

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Amyloid, the presenilins and Alzheimer's disease

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Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

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BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

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Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

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Identifiers

10.1074/JBC.M104350200

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

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