(Q53378253)

13 May 2018

title

Copper-mediated amyloid-beta toxicity is associated with an intermolecular histidine bridge. (English)

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13 May 2018

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3

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Ashley I. Bush

11

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Frances Šeparović

13

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Roberto Cappai

15

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David Smith

David P Smith

1

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John D Wade

John D Wade

10

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Simon C Drew

Simon C Drew

12

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Colin L. Masters

14

Colin L Masters

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13 May 2018

9

Keyla Perez

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13 May 2018

Giuseppe Donato Ciccotosto

6

Giuseppe D Ciccotosto

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13 May 2018

Kevin J Barnham

16

Kevin J Barnham

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13 May 2018

Deborah J Tew

8

Deborah J Tew

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13 May 2018

author name string

Danielle G Smith

2

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13 May 2018

John F Boas

4

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13 May 2018

John R Pilbrow

5

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Tong-Lay Lau

7

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language of work or name

English

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publication date

4 April 2006

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13 May 2018

Journal of Biological Chemistry

number of pages

10

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based on heuristic

inferred from page(s)

published in

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13 May 2018

volume

281

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13 May 2018

issue

22

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13 May 2018

page(s)

15145-15154

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13 May 2018

The metallobiology of Alzheimer's disease

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600417200

Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600417200

Metal ions, pH, and cholesterol regulate the interactions of Alzheimer's disease amyloid-beta peptide with membrane lipid

21 January 2018

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Methylation of the imidazole side chains of the Alzheimer disease amyloid-beta peptide results in abolition of superoxide dismutase-like structures and inhibition of neurotoxicity

21 January 2018

1 reference

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Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction.

21 January 2018

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Amyloidosis of Alzheimer's Abeta peptides: solid-state nuclear magnetic resonance, electron paramagnetic resonance, transmission electron microscopy, scanning transmission electron microscopy and atomic force microscopy studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600417200

Copper binding to the amyloid-beta (Abeta) peptide associated with Alzheimer's disease: folding, coordination geometry, pH dependence, stoichiometry, and affinity of Abeta-(1-28): insights from a range of complementary spectroscopic techniques

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600417200

N-Terminal deletions modify the Cu2+ binding site in amyloid-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600417200

Structural changes of region 1-16 of the Alzheimer disease amyloid beta-peptide upon zinc binding and in vitro aging

21 January 2018

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The channel hypothesis of Alzheimer's disease: current status

21 January 2018

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Disruption of calcium homeostasis in the pathogenesis of Alzheimer's disease and other conformational diseases

21 January 2018

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Alzheimer disease beta-amyloid activity mimics cholesterol oxidase

21 January 2018

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Improved preparation of amyloid-beta peptides using DBU as Nalpha-Fmoc deprotection reagent.

21 January 2018

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XSophe-Sophe-XeprView. A computer simulation software suite (v. 1.1.3) for the analysis of continuous wave EPR spectra.

21 January 2018

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Enhanced toxicity and cellular binding of a modified amyloid beta peptide with a methionine to valine substitution

21 January 2018

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Copper mediates dityrosine cross-linking of Alzheimer's amyloid-beta

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M600417200

Structural implications derived from the analysis of electron paramagnetic resonance spectra of natural and artificial copper proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600417200

Atomic structures of wild-type and thermostable mutant recombinant human Cu,Zn superoxide dismutase

21 January 2018

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Neurotoxic, redox-competent Alzheimer's beta-amyloid is released from lipid membrane by methionine oxidation

21 January 2018

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Membrane-disordering effects of beta-amyloid peptides

21 January 2018

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Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease beta-amyloid

21 January 2018

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Copper reduction by copper binding proteins and its relation to neurodegenerative diseases

21 January 2018

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Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

21 January 2018

1 reference

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Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600417200

Clioquinol, a drug for Alzheimer's disease specifically interfering with brain metal metabolism: structural characterization of its zinc(II) and copper(II) complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600417200

Zinc-induced Alzheimer's Abeta1-40 aggregation is mediated by conformational factors.

21 January 2018

1 reference

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Characterization of chemical exchange between soluble and aggregated states of beta-amyloid by solution-state NMR upon variation of salt conditions.

21 January 2018

1 reference

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Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).

21 January 2018

1 reference

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Hydrogen peroxide mediates amyloid beta protein toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600417200

Hydrogen peroxide is generated during the very early stages of aggregation of the amyloid peptides implicated in Alzheimer disease and familial British dementia.

21 January 2018

1 reference

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Two types of Alzheimer's beta-amyloid (1-40) peptide membrane interactions: aggregation preventing transmembrane anchoring versus accelerated surface fibril formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600417200

Cholesterol is necessary both for the toxic effect of Abeta peptides on vascular smooth muscle cells and for Abeta binding to vascular smooth muscle cell membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600417200

Metal ion-dependent effects of clioquinol on the fibril growth of an amyloid {beta} peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600417200

Cholesterol is an important factor affecting the membrane insertion of beta-amyloid peptide (A beta 1-40), which may potentially inhibit the fibril formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600417200

The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction†

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600417200

21 January 2018

Identifiers

DOI

10.1074/JBC.M600417200

1 reference

13 May 2018

PubMed ID

16595673

1 reference

13 May 2018