(Q35104793)

6 August 2017

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title

The metallobiology of Alzheimer's disease (English)

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6 August 2017

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Ashley I Bush

1

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publication date

1 April 2003

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6 August 2017

Trends in Neurosciences

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6 August 2017

26

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6 August 2017

207-214

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6 August 2017

4

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Metal chelation as a potential therapy for Alzheimer's disease.

6 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

Augmented senile plaque load in aged female beta-amyloid precursor protein-transgenic mice

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https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

The structure of neuritic plaque in the cerebral cortex of aged rats

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https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

Aqueous dissolution of Alzheimer's disease Abeta amyloid deposits by biometal depletion.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

Rapid induction of Alzheimer A beta amyloid formation by zinc.

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https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

Metal binding modes of Alzheimer's amyloid beta-peptide in insoluble aggregates and soluble complexes.

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https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

Evidence for release of copper in the brain: depolarization-induced release of newly taken-up 67copper

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https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

Release of endogenous Zn2+ from brain tissue during activity.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

Stimulation-induced uptake and release of zinc in hippocampal slices

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https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

Copper, iron and zinc in Alzheimer's disease senile plaques.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

Histochemically-reactive zinc in amyloid plaques, angiopathy, and degenerating neurons of Alzheimer's diseased brains

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https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

Histidine-13 is a crucial residue in the zinc ion-induced aggregation of the A beta peptide of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits

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https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

Metal switch for amyloid formation: insight into the structure of the nucleus

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https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

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https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

Elimination of zinc from synaptic vesicles in the intact mouse brain by disruption of the ZnT3 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

Contribution by synaptic zinc to the gender-disparate plaque formation in human Swedish mutant APP transgenic mice

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https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

ZnT-3, a putative transporter of zinc into synaptic vesicles

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https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

Synaptically released zinc: physiological functions and pathological effects.

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https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

Metals and neuroscience.

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https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

Characterization of Copper Interactions with Alzheimer Amyloid β Peptides

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https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

Ferritin is a component of the neuritic (senile) plaque in Alzheimer dementia.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction†

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction.

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https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

Redox-active iron mediates amyloid-beta toxicity

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https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

Oxidative damage in Alzheimer's.

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https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

Neuronal oxidative stress precedes amyloid-beta deposition in Down syndrome

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https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

Oxidative damage is the earliest event in Alzheimer disease

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https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

Protection against amyloid beta peptide toxicity by zinc.

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https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

Evidence that the beta-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of abeta by zinc

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

In Situ Oxidative Catalysis by Neurofibrillary Tangles and Senile Plaques in Alzheimer’s Disease

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

The levels of soluble versus insoluble brain Abeta distinguish Alzheimer's disease from normal and pathologic aging.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

Water-soluble Abeta (N-40, N-42) oligomers in normal and Alzheimer disease brains.

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https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

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https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

Metal ions, pH, and cholesterol regulate the interactions of Alzheimer's disease amyloid-beta peptide with membrane lipid

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https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

Overexpression of Alzheimer's disease amyloid-beta opposes the age-dependent elevations of brain copper and iron.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

Oxidative stress increases production of beta-amyloid precursor protein and beta-amyloid (Abeta) in mammalian lenses, and Abeta has toxic effects on lens epithelial cells.

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https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

65zinc uptake from blood into brain and other tissues in the rat.

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https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

65Zn uptake from blood into brain in the rat

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https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

Reduced glucose transporter at the blood-brain barrier and in cerebral cortex in Alzheimer disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

Differential degeneration of the cerebral microvasculature in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

Zinc (II) selectively enhances the inhibition of coagulation factor XIa by protease nexin-2/amyloid beta-protein precursor

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

Evidence for a copper-binding superfamily of the amyloid precursor protein

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https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice

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https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript

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https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

Amyloid-beta is an antioxidant for lipoproteins in cerebrospinal fluid and plasma

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https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

Resistance of human cerebrospinal fluid to in vitro oxidation is directly related to its amyloid-beta content

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https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

A Novel Function of Monomeric Amyloid β-Protein Serving as an Antioxidant Molecule against Metal-Induced Oxidative Damage

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

Elevation of serum copper levels in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

Effects of 2,2'-dipyridyl and related compounds on platelet prostaglandin synthesis and platelet function

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

Ibuprofen protects platelet cyclooxygenase from irreversible inhibition by aspirin

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

Treatment of Alzheimer's disease with clioquinol

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https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

Zinc-induced Alzheimer's Abeta1-40 aggregation is mediated by conformational factors.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

The binding of receptor-recognized alpha2-macroglobulin to the low density lipoprotein receptor-related protein and the alpha2M signaling receptor is decoupled by oxidation

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

Changes in uptake of vitamin B(12) and trace metals in brains of mice treated with clioquinol

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

Intramuscular desferrioxamine in patients with Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

Reversibility of scrapie inactivation is enhanced by copper.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

Induction of nitric oxide-dependent apoptosis in motor neurons by zinc-deficient superoxide dismutase

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

3-Hydroxykynurenine and 3-Hydroxyanthranilic Acid Generate Hydrogen Peroxide and Promote α-Crystallin Cross-Linking by Metal Ion Reduction†

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

Copper(II)-induced self-oligomerization of alpha-synuclein.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

Oxidation of Abeta and plaque biogenesis in Alzheimer's disease and Down syndrome.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

The HHQK domain of beta-amyloid provides a structural basis for the immunopathology of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2803%2900067-5

7 January 2021

10.1016/S0166-2236(03)00067-5

Identifiers

DOI

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6 August 2017

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PubMed ID

12689772