(Q45271567)

11 December 2017

title

Metal ion-dependent effects of clioquinol on the fibril growth of an amyloid {beta} peptide (English)

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11 December 2017

Bakthisaran Raman

1

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11 December 2017

Tadato Ban

2

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11 December 2017

Kei-Ichi Yamaguchi

3

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11 December 2017

Miyo Sakai

4

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11 December 2017

Tomoji Kawai

5

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11 December 2017

Hironobu Naiki

6

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11 December 2017

Yuji Goto

7

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11 December 2017

language of work or name

English

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publication date

16 February 2005

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Journal of Biological Chemistry

11 December 2017

published in

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11 December 2017

volume

280

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11 December 2017

issue

16

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11 December 2017

page(s)

16157-16162

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

11 December 2017

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Production of the Alzheimer amyloid beta protein by normal proteolytic processing

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Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids

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The metallobiology of Alzheimer's disease

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Transition metal chelator therapy--a potential treatment for Alzheimer's disease?

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Metals in our minds: therapeutic implications for neurodegenerative disorders

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Trace amounts of copper in water induce beta-amyloid plaques and learning deficits in a rabbit model of Alzheimer's disease

21 January 2018

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Copper, iron and zinc in Alzheimer's disease senile plaques.

21 January 2018

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Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Abeta production in APP23 transgenic mice

21 January 2018

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Overexpression of Alzheimer's disease amyloid-beta opposes the age-dependent elevations of brain copper and iron.

21 January 2018

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Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice

21 January 2018

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Metal binding and oxidation of amyloid-beta within isolated senile plaque cores: Raman microscopic evidence

21 January 2018

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Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits

21 January 2018

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Copper binding to the amyloid-beta (Abeta) peptide associated with Alzheimer's disease: folding, coordination geometry, pH dependence, stoichiometry, and affinity of Abeta-(1-28): insights from a range of complementary spectroscopic techniques

21 January 2018

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Metal binding modes of Alzheimer's amyloid beta-peptide in insoluble aggregates and soluble complexes.

21 January 2018

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Rapid induction of Alzheimer A beta amyloid formation by zinc.

21 January 2018

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Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis.

21 January 2018

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Zinc-induced Alzheimer's Abeta1-40 aggregation is mediated by conformational factors.

21 January 2018

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New insights on how metals disrupt amyloid beta-aggregation and their effects on amyloid-beta cytotoxicity

21 January 2018

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Beta-amyloid protein oligomers induced by metal ions and acid pH are distinct from those generated by slow spontaneous ageing at neutral pH.

21 January 2018

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Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

21 January 2018

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Spherical aggregates of beta-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3beta

21 January 2018

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Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial

21 January 2018

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Clioquinol, a drug for Alzheimer's disease specifically interfering with brain metal metabolism: structural characterization of its zinc(II) and copper(II) complexes

21 January 2018

1 reference

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Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.

21 January 2018

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Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

21 January 2018

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Fluorometric determination of amyloid fibrils in vitro using the fluorescent dye, thioflavin T1.

21 January 2018

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Direct observation of amyloid fibril growth monitored by thioflavin T fluorescence

21 January 2018

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Direct observation of Abeta amyloid fibril growth and inhibition

21 January 2018

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Ideas of order for amyloid fibril structure

21 January 2018

1 reference

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From the globular to the fibrous state: protein structure and structural conversion in amyloid formation.

21 January 2018

1 reference

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Characterization of Copper Interactions with Alzheimer Amyloid β Peptides

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M500309200

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11 December 2017

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