(Q30649552)

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Translocator protein (18 kDa)/peripheral benzodiazepine receptor specific ligands induce microglia functions consistent with an activated state

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

20 September 2017

Translocator protein (18 kDa)/peripheral benzodiazepine receptor specific ligands induce microglia functions consistent with an activated state (English)

1 reference

Europe PubMed Central

PMC publication ID

20 September 2017

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author name string

Judy Choi

1

1 reference

Europe PubMed Central

PMC publication ID

20 September 2017

Masataka Ifuku

2

1 reference

Europe PubMed Central

PMC publication ID

20 September 2017

Mami Noda

3

1 reference

Europe PubMed Central

PMC publication ID

20 September 2017

Tomás R Guilarte

4

1 reference

Europe PubMed Central

PMC publication ID

20 September 2017

publication date

1 February 2011

1 reference

Europe PubMed Central

PMC publication ID

20 September 2017

1 reference

Europe PubMed Central

PMC publication ID

20 September 2017

59

1 reference

Europe PubMed Central

PMC publication ID

20 September 2017

2

1 reference

Europe PubMed Central

PMC publication ID

20 September 2017

219-230

1 reference

Europe PubMed Central

PMC publication ID

20 September 2017

Inflammatory neurodegeneration and mechanisms of microglial killing of neurons

1 reference

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The P2X7 purinergic receptor: from physiology to neurological disorders.

1 reference

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Neuroprotective effects of a ligand of translocator protein-18 kDa (Ro5-4864) in experimental diabetic neuropathy.

1 reference

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Translocator protein (18 kDa) TSPO: an emerging therapeutic target in neurotrauma

1 reference

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NOX enzymes in the central nervous system: from signaling to disease

1 reference

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NADPH oxidase as a therapeutic target in Alzheimer's disease

1 reference

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Microglia: gatekeepers of central nervous system immunology.

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Classical inhibitors of NOX NAD(P)H oxidases are not specific.

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VDAC activation by the 18 kDa translocator protein (TSPO), implications for apoptosis

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Translocator protein 18 kDa (TSPO): molecular sensor of brain injury and repair

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Mechanisms of inflammatory neurodegeneration: iNOS and NADPH oxidase

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Activated macrophages in HIV encephalitis and a macaque model show increased [3H](R)-PK11195 binding in a PI3-kinase-dependent manner

1 reference

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Channel-like functions of the 18-kDa translocator protein (TSPO): regulation of apoptosis and steroidogenesis as part of the host-defense response

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Translocator protein (18 kDa) ligand PK 11195 induces transient mitochondrial Ca2+ release leading to transepithelial Cl- secretion in HT-29 human colon cancer cells

1 reference

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PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond?

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Microglia-mediated neurotoxicity: uncovering the molecular mechanisms

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The peripheral-type benzodiazepine receptor is involved in control of Ca2+-induced permeability transition pore opening in rat brain mitochondria

1 reference

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The P2Y12 receptor regulates microglial activation by extracellular nucleotides

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Fibrillar beta-amyloid peptide Abeta1-40 activates microglial proliferation via stimulating TNF-alpha release and H2O2 derived from NADPH oxidase: a cell culture study

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28 July 2018

Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function

1 reference

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Microglia proliferation is regulated by hydrogen peroxide from NADPH oxidase

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In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease

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Toll-like receptor signalling

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PET imaging of brain macrophages using the peripheral benzodiazepine receptor in a macaque model of neuroAIDS

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Effects on free radical generation by ligands of the peripheral benzodiazepine receptor in cultured neural cells

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Immune function of microglia

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Diphenyleneiodonium, an NAD(P)H oxidase inhibitor, also potently inhibits mitochondrial reactive oxygen species production

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PK11195 binding to the peripheral benzodiazepine receptor as a marker of microglia activation in multiple sclerosis and experimental autoimmune encephalomyelitis

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The peripheral benzodiazepine receptor is a sensitive indicator of domoic acid neurotoxicity

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Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts

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Differentiation between two ligands for peripheral benzodiazepine binding sites, [3H]R05-4864 and [3H]PK 11195, by thermodynamic studies

1 reference

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The role of protein kinase C in cell surface signal transduction and tumour promotion

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https://api.crossref.org/works/10.1002%2FGLIA.21091

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Isolation of the mitochondrial benzodiazepine receptor: association with the voltage-dependent anion channel and the adenine nucleotide carrier

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Non-PKC DAG/phorbol-ester receptor(s) inhibit complement receptor-3 and nPKC inhibit scavenger receptor-AI/II-mediated myelin phagocytosis but cPKC, PI3k, and PLCgamma activate myelin phagocytosis by both

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Role of the peripheral benzodiazepine receptor in sensory neuron regeneration

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Peripheral benzodiazepine receptor ligand PK11195 reduces microglial activation and neuronal death in quinolinic acid-injected rat striatum

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Microglial activation and dopamine terminal loss in early Parkinson's disease

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Peripheral benzodiazepine receptor imaging in CNS demyelination: functional implications of anatomical and cellular localization

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Assessment of neuroinflammation and microglial activation in Alzheimer's disease with radiolabelled PK11195 and single photon emission computed tomography. A pilot study

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25 November 2018

Inhibition of lipopolysaccharide-induced cyclooxygenase-2, tumor necrosis factor-alpha and [Ca2+]i responses in human microglia by the peripheral benzodiazepine receptor ligand PK11195.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4425360

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PK 11195 attenuates kainic acid-induced seizures and alterations in peripheral-type benzodiazepine receptor (PBR) protein components in the rat brain

1 reference

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IL-1 receptor antagonist prevents apoptosis and caspase-3 activation after spinal cord injury.

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In-vivo measurement of activated microglia in dementia

1 reference

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Enigma of the peripheral benzodiazepine receptor

1 reference

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Regional and temporal expression of the peripheral benzodiazepine receptor in MPTP neurotoxicity

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PK11195, a ligand of the mitochondrial benzodiazepine receptor, facilitates the induction of apoptosis and reverses Bcl-2-mediated cytoprotection.

1 reference

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Cellular and subcellular localization of peripheral benzodiazepine receptors after trimethyltin neurotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/21125642

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In vivo imaging of activated microglia using [11C]PK11195 and positron emission tomography in patients after ischemic stroke

1 reference

https://pubmed.ncbi.nlm.nih.gov/21125642

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced expression of peripheral benzodiazepine receptors in trimethyltin-exposed rat brain: a biomarker of neurotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/21125642

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based on heuristic

inferred from PubMed ID database lookup

Galectin-3/MAC-2, Ras and PI3K activate complement receptor-3 and scavenger receptor-AI/II mediated myelin phagocytosis in microglia

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Characteristics of the inhibition of NADPH oxidase activation in neutrophils by apocynin, a methoxy-substituted catechol

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Translocator protein 18 kDa is involved in the regulation of reactive gliosis

1 reference

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inferred from PubMed ID database lookup

The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in vivo imaging of microglia as a measure of disease activity

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https://pubmed.ncbi.nlm.nih.gov/21125642

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Evolution of microglial activation in patients after ischemic stroke: a [11C](R)-PK11195 PET study

1 reference

https://pubmed.ncbi.nlm.nih.gov/21125642

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1002/GLIA.21091

1 reference

Europe PubMed Central

PMC publication ID

20 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

20 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

20 September 2017

ResearchGate publication ID

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