(Q30658905)

10 August 2017

The pattern of congenital heart defects arising from reduced Tbx5 expression is altered in a Down syndrome mouse model (English)

1 reference

10 August 2017

0 references

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26208718%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

Jeffrey D Steimle

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26208718%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

Sally A. Camper

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26208718%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

author name string

Renita C Polk

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26208718%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

Huiqing Li

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26208718%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

Ivan P Moskowitz

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26208718%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

Roger H Reeves

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26208718%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

publication date

25 July 2015

1 reference

BMC Developmental Biology

10 August 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26208718%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

volume

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26208718%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

page(s)

30

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26208718%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1186/s12861-015-0080-y

14 June 2020

exact match

0 references

cites work

GXD: a community resource of mouse Gene Expression Data

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4514943

Cardiac outflow tract anomalies

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4514943

An excess of deleterious variants in VEGF-A pathway genes in Down-syndrome-associated atrioventricular septal defects

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4514943

A Sonic hedgehog (Shh) response deficit in trisomic cells may be a common denominator for multiple features of Down syndrome

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4514943

Genetic modifiers predisposing to congenital heart disease in the sensitized Down syndrome population

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4514943

Pitx2 confers left morphological, molecular, and functional identity to the sinus venosus myocardium

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4514943

Molecular characterization of the translocation breakpoints in the Down syndrome mouse model Ts65Dn.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4514943

Identification of the translocation breakpoints in the Ts65Dn and Ts1Cje mouse lines: relevance for modeling Down syndrome

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4514943

Co-occupancy by multiple cardiac transcription factors identifies transcriptional enhancers active in heart.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4514943

Pitx2-dependent occupancy by histone deacetylases is associated with T-box gene regulation in mammalian abdominal tissue

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4514943

Reptilian heart development and the molecular basis of cardiac chamber evolution

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4514943

The power of comparative and developmental studies for mouse models of Down syndrome

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4514943

Heart disease and stroke statistics--2007 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4514943

The UCSC genome browser database: update 2007.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4514943

Tbx5-dependent rheostatic control of cardiac gene expression and morphogenesis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4514943

Pitx2 regulates cardiac left-right asymmetry by patterning second cardiac lineage-derived myocardium

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4514943

Conserved regulation and role of Pitx2 in situs-specific morphogenesis of visceral organs

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4514943

Tbx1 affects asymmetric cardiac morphogenesis by regulating Pitx2 in the secondary heart field

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4514943

Perinatal loss of Ts65Dn Down syndrome mice.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4514943

The role of Pitx2 during cardiac development. Linking left-right signaling and congenital heart diseases

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4514943

ADAMTS1/METH1 Inhibits Endothelial Cell Proliferation by Direct Binding and Sequestration of VEGF165

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4514943

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4514943

A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4514943

Characterization of the TBX5 binding site and analysis of mutations that cause Holt-Oram syndrome

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4514943

Regulation of left-right asymmetry by thresholds of Pitx2c activity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4514943

Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4514943

The mutation spectrum in Holt-Oram syndrome

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4514943

Mouse Pitx2 deficiency leads to anomalies of the ventral body wall, heart, extra- and periocular mesoderm and right pulmonary isomerism

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4514943

Multiple left-right asymmetry defects in Shh(-/-) mutant mice unveil a convergence of the shh and retinoic acid pathways in the control of Lefty-1

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4514943

Pitx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth morphogenesis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4514943

Function of Rieger syndrome gene in left-right asymmetry and craniofacial development

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4514943

Dosage requirement of Pitx2 for development of multiple organs

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4514943

The transcription factor Pitx2 mediates situs-specific morphogenesis in response to left-right asymmetric signals

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4514943

Pitx2 determines left-right asymmetry of internal organs in vertebrates.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4514943

Mutations in human TBX5 [corrected] cause limb and cardiac malformation in Holt-Oram syndrome

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4514943

Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4514943

Holt-Oram syndrome: a clinical genetic study

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4514943

Congenital heart disease in infants with Down's syndrome

20 June 2018

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4514943

20 June 2018

https://api.crossref.org/works/10.1186%2FS12861-015-0080-Y

A mouse model for Down syndrome exhibits learning and behaviour deficits.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4514943

Epidemiology of Down syndrome in 118,265 consecutive births

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4514943

Epidemiology of major congenital heart defects in Sweden, 1981-1986

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4514943

Improved ascertainment of cardiovascular malformations in infants with Down's syndrome, Atlanta, 1968 through 1989. Implications for the interpretation of increasing rates of cardiovascular malformations in surveillance systems

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4514943

Chamber-specific cardiac expression of Tbx5 and heart defects in Holt-Oram syndrome.

20 June 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12861-015-0080-Y

Postnatal lethality and cardiac anomalies in the Ts65Dn Down syndrome mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12861-015-0080-Y

TBX5 mutations in non-Holt-Oram syndrome (HOS) malformed hearts

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12861-015-0080-Y

Pitx2 expression defines a left cardiac lineage of cells: evidence for atrial and ventricular molecular isomerism in the iv/iv mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12861-015-0080-Y

sonic hedgehog is required in pulmonary endoderm for atrial septation

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12861-015-0080-Y

Proteolytic cleavage of versican during cardiac cushion morphogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12861-015-0080-Y

EMAGE: Electronic Mouse Atlas of Gene Expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12861-015-0080-Y

Human chromosome 21 gene expression atlas in the mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12861-015-0080-Y

Pitx2 distinguishes subtypes of terminally differentiated neurons in the developing mouse neuroepithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12861-015-0080-Y

Using TESS to predict transcription factor binding sites in DNA sequence

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4514943

Population-based study of congenital heart defects in Down syndrome.

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4514943

Characterization of the cardiac phenotype in neonatal Ts65Dn mice

25 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26208718

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Overlapping trisomies for human chromosome 21 orthologs produce similar effects on skull and brain morphology of Dp(16)1Yey and Ts65Dn mice

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26208718

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Congenital cardiovascular malformations associated with chromosome abnormalities: an epidemiologic study

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26208718

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1186/S12861-015-0080-Y

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26208718%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

14 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26208718%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26208718%20AND%20SRC:MED&resulttype=core&format=json