(Q30681823)

13 August 2017

Intravitreal AAV2.COMP-Ang1 Prevents Neurovascular Degeneration in a Murine Model of Diabetic Retinopathy (English)

1 reference

13 August 2017

1 reference

1 reference

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26340930%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Reinhold J Medina

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26340930%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Subrata Das

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26340930%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

David Križaj

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26340930%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Alan W Stitt

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26340930%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

author name string

Judd M Cahoon

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26340930%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Ruju R Rai

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26340930%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Lara S Carroll

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26340930%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Hironori Uehara

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26340930%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Xiaohui Zhang

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26340930%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Santosh K Muddana

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26340930%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Paul R Olson

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26340930%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Spencer Nielson

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26340930%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Kortnie Walker

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26340930%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Maggie M Flood

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26340930%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Wyatt B Messenger

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26340930%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Bonnie J Archer

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26340930%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Peter Barabas

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26340930%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Christopher C Gibson

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26340930%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Dean Y Li

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26340930%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Gou Y Koh

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26340930%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Guangping Gao

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26340930%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Balamurali K Ambati

23

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26340930%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

language of work or name

English

0 references

publication date

4 September 2015

1 reference

13 August 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26340930%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

volume

64

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26340930%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

issue

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26340930%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

page(s)

4247-4259

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26340930%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

1 June 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4657578/fullTextXML

inferred from PubMed Central ID database lookup

cites work

COMP-Ang1 Potentiates EPC Treatment of Ischemic Brain Injury by Enhancing Angiogenesis Through Activating AKT-mTOR Pathway and Promoting Vascular Migration Through Activating Tie2-FAK Pathway

1 reference

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What have we learnt about the management of diabetic macular edema in the antivascular endothelial growth factor and corticosteroid era?

28 July 2018

1 reference

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AAV2 delivery of Flt23k intraceptors inhibits murine choroidal neovascularization

28 July 2018

1 reference

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Loss of synaptic connectivity, particularly in second order neurons is a key feature of diabetic retinal neuropathy in the Ins2Akita mouse

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657578

Neutralization of vascular endothelial growth factor slows progression of retinal nonperfusion in patients with diabetic macular edema

28 July 2018

1 reference

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Acridine orange leukocyte fluorography in mice.

28 July 2018

1 reference

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Circulating mononuclear progenitor cells: differential roles for subpopulations in repair of retinal vascular injury

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657578

Early visual deficits in streptozotocin-induced diabetic long evans rats

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657578

Retinal angiogenesis in the Ins2(Akita) mouse model of diabetic retinopathy

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657578

Interleukin receptor activates a MYD88-ARNO-ARF6 cascade to disrupt vascular stability.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657578

Global prevalence and major risk factors of diabetic retinopathy

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657578

Coexpression of angiopoietin-1 with VEGF increases the structural integrity of the blood-brain barrier and reduces atrophy volume

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657578

Myeloid angiogenic cells act as alternative M2 macrophages and modulate angiogenesis through interleukin-8.

28 July 2018

1 reference

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The RESTORE study: ranibizumab monotherapy or combined with laser versus laser monotherapy for diabetic macular edema.

28 July 2018

1 reference

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Intravitreal injection of AAV2 transduces macaque inner retina

28 July 2018

1 reference

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TNFalpha is required for late BRB breakdown in diabetic retinopathy, and its inhibition prevents leukostasis and protects vessels and neurons from apoptosis

28 July 2018

1 reference

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Outgrowth endothelial cells: characterization and their potential for reversing ischemic retinopathy

28 July 2018

1 reference

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Molecular analysis of endothelial progenitor cell (EPC) subtypes reveals two distinct cell populations with different identities.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657578

Randomized trial evaluating ranibizumab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657578

Gene therapy for Leber's congenital amaurosis is safe and effective through 1.5 years after vector administration

28 July 2018

1 reference

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Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system

28 July 2018

1 reference

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Selective loss of inner retinal layer thickness in type 1 diabetic patients with minimal diabetic retinopathy

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657578

The pleiotropic effects of simvastatin on retinal microvascular endothelium has important implications for ischaemic retinopathies

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657578

TNF-alpha is critical for ischemia-induced leukostasis, but not retinal neovascularization nor VEGF-induced leakage

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657578

Global prevalence of diabetes: estimates for the year 2000 and projections for 2030

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657578

COMP-Ang1: a designed angiopoietin-1 variant with nonleaky angiogenic activity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657578

Angiopoietin-2 causes pericyte dropout in the normal retina: evidence for involvement in diabetic retinopathy.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657578

Recombinant angiopoietin-1 restores higher-order architecture of growing blood vessels in mice in the absence of mural cells.

28 July 2018

1 reference

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Complementary actions of VEGF and angiopoietin-1 on blood vessel growth and leakage

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657578

Suppression of diabetic retinopathy with angiopoietin-1.

28 July 2018

1 reference

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Vascular endothelial growth factor (VEGF)-induced retinal vascular permeability is mediated by intercellular adhesion molecule-1 (ICAM-1).

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657578

Angiopoietin-1 protects the adult vasculature against plasma leakage.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657578

Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657578

Accelerated death of retinal microvascular cells in human and experimental diabetic retinopathy

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657578

Factors protective against retinopathy in insulin-dependent diabetics free of retinopathy for 30 years.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657578

Donor Heart Treatment With COMP-Ang1 Limits Ischemia-Reperfusion Injury and Rejection of Cardiac Allografts.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657578

Protective role of COMP-Ang1 in ischemic rat brain

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657578

COMP-angiopoietin-1 decreases lipopolysaccharide-induced acute kidney injury

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657578

Dendrite remodeling and other abnormalities in the retinal ganglion cells of Ins2 Akita diabetic mice

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657578

Leukocytes in diabetic retinopathy

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657578

Angiopoietin-1 prevents VEGF-induced endothelial permeability by sequestering Src through mDia.

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657578

The Ins2Akita mouse as a model of early retinal complications in diabetes

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657578

Angiopoietin concentrations in diabetic retinopathy

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657578

A central role for inflammation in the pathogenesis of diabetic retinopathy

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657578

Leukocyte-mediated endothelial cell injury and death in the diabetic retina

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4657578

Angiopoietin-1 guides directional angiogenesis through integrin αvβ5 signaling for recovery of ischemic retinopathy.

25 November 2018

1 reference

12 December 2020

Loss of cholinergic and dopaminergic amacrine cells in streptozotocin-diabetic rat and Ins2Akita-diabetic mouse retinas

1 reference

12 December 2020

Retinal vascular patterns. IV. Diabetic retinopathy

1 reference

12 December 2020

1 reference

12 December 2020

The 1-year results of CLEAR-IT 2, a phase 2 study of vascular endothelial growth factor trap-eye dosed as-needed after 12-week fixed dosing

1 reference

12 December 2020

Identifiers

DOI

10.2337/DB14-1030

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26340930%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26340930%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

PubMed publication ID

26340930

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26340930%20AND%20SRC:MED&resulttype=core&format=json