(Q37398561)

20 August 2017

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title

Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system (English)

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20 August 2017

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Hellmut G Augustin

1

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Kari Alitalo

object named as

Kari Alitalo

series ordinal

4

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author name string

Gou Young Koh

series ordinal

2

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20 August 2017

Gavin Thurston

series ordinal

3

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20 August 2017

publication date

1 March 2009

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Nature Reviews Molecular Cell Biology

20 August 2017

published in

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20 August 2017

volume

10

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20 August 2017

issue

3

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20 August 2017

page(s)

165-177

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Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid

20 August 2017

cites work

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Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells

31 March 2020

1 reference

A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains

31 March 2020

1 reference

Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system

31 March 2020

1 reference

Molecular cloning and characterization of mouse TIE and TEK receptor tyrosine kinase genes and their expression in hematopoietic stem cells

31 March 2020

1 reference

Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning

31 March 2020

1 reference

Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis

31 March 2020

1 reference

Angiopoietins 3 and 4: diverging gene counterparts in mice and humans

31 March 2020

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Angiopoietin-4 inhibits angiogenesis and reduces interstitial fluid pressure

31 March 2020

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Angiopoietin-3 inhibits pulmonary metastasis by inhibiting tumor angiogenesis

31 March 2020

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Biological characterization of angiopoietin-3 and angiopoietin-4

31 March 2020

1 reference

In vivo actions of angiopoietins on quiescent and remodeling blood and lymphatic vessels in mouse airways and skin

31 March 2020

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The role of angiopoietin-like proteins in angiogenesis and metabolism

31 March 2020

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Molecular regulation of angiogenesis and lymphangiogenesis

31 March 2020

1 reference

TIE1 and TIE2 receptor tyrosine kinases inversely regulate embryonic angiogenesis by the mechanism of intussusceptive microvascular growth

31 March 2020

1 reference

Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation

31 March 2020

1 reference

Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo

31 March 2020

1 reference

Critical role of the TIE2 endothelial cell receptor in the development of definitive hematopoiesis

31 March 2020

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The receptor tyrosine kinase TIE is required for integrity and survival of vascular endothelial cells.

31 March 2020

1 reference

Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis

31 March 2020

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Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1.

31 March 2020

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Angiopoietin-2 sensitizes endothelial cells to TNF-alpha and has a crucial role in the induction of inflammation

31 March 2020

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Angiopoietin-2 plays an important role in retinal angiogenesis

31 March 2020

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Dysmorphogenesis of kidney cortical peritubular capillaries in angiopoietin-2-deficient mice

31 March 2020

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Increased vascularization in mice overexpressing angiopoietin-1

31 March 2020

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Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1

31 March 2020

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Angiopoietin-1 protects the adult vasculature against plasma leakage.

31 March 2020

1 reference

Angiopoietin-1 reduces VEGF-stimulated leukocyte adhesion to endothelial cells by reducing ICAM-1, VCAM-1, and E-selectin expression

31 March 2020

1 reference

Angiopoietin-1 is an antipermeability and anti-inflammatory agent in vitro and targets cell junctions

31 March 2020

1 reference

Basal and angiopoietin-1-mediated endothelial permeability is regulated by sphingosine kinase-1

31 March 2020

1 reference

Tie-ing the antiinflammatory effect of angiopoietin-1 to inhibition of NF-kappaB

31 March 2020

1 reference

Angiopoietin-1 Protects Against the Development of Cardiac Allograft Arteriosclerosis

31 March 2020

2 references

31 March 2020

12 December 2020

Protective role of angiopoietin-1 in endotoxic shock.

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Angiopoietin-1 inhibits irradiation- and mannitol-induced apoptosis in endothelial cells

31 March 2020

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Angiopoietin-1 negatively regulates expression and activity of tissue factor in endothelial cells

31 March 2020

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A cyclosporine-sensitive psoriasis-like disease produced in Tie2 transgenic mice

31 March 2020

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Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2

31 March 2020

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Angiopoietin-2 impairs revascularization after limb ischemia

31 March 2020

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Angiopoietin-2 displays VEGF-dependent modulation of capillary structure and endothelial cell survival in vivo

31 March 2020

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Angiopoietin-2 enhances retinal vessel sensitivity to vascular endothelial growth factor

31 March 2020

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Different effects of angiopoietin-2 in different vascular beds: new vessels are most sensitive.

31 March 2020

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Angiopoietin-2 causes pericyte dropout in the normal retina: evidence for involvement in diabetic retinopathy.

31 March 2020

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Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death

31 March 2020

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Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF.

31 March 2020

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Activation of the tie2 receptor by angiopoietin-1 enhances tumor vessel maturation and impairs squamous cell carcinoma growth

31 March 2020

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Expression and function of angiopoietin-1 in breast cancer.

31 March 2020

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Angiopoietin-1 promotes tumor angiogenesis in a rat glioma model

31 March 2020

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Molecular regulation of vessel maturation

31 March 2020

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Angiopoietin-2 induces human glioma invasion through the activation of matrix metalloprotease-2.

31 March 2020

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Angiopoietin 2 displays a vascular endothelial growth factor dependent synergistic effect in hepatocellular carcinoma development in mice.

31 March 2020

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Angiopoietin-2 is implicated in the regulation of tumor angiogenesis

31 March 2020

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Systemic overexpression of angiopoietin-2 promotes tumor microvessel regression and inhibits angiogenesis and tumor growth

31 March 2020

1 reference

Inhibition of tumor angiogenesis using a soluble receptor establishes a role for Tie2 in pathologic vascular growth

31 March 2020

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Antiangiogenic gene therapy targeting the endothelium-specific receptor tyrosine kinase Tie2

31 March 2020

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Phenotypic knockout of VEGF-R2 and Tie-2 with an intradiabody reduces tumor growth and angiogenesis in vivo

31 March 2020

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Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2

31 March 2020

1 reference

Pyridinylimidazole inhibitors of Tie2 kinase

31 March 2020

1 reference

Evolution of a highly selective and potent 2-(pyridin-2-yl)-1,3,5-triazine Tie-2 kinase inhibitor

31 March 2020

1 reference

Alkynylpyrimidine amide derivatives as potent, selective, and orally active inhibitors of Tie-2 kinase

31 March 2020

1 reference

Discovery of novel benzimidazoles as potent inhibitors of TIE-2 and VEGFR-2 tyrosine kinase receptors

31 March 2020

1 reference

Crystal structures of the Tie2 receptor ectodomain and the angiopoietin-2-Tie2 complex

31 March 2020

1 reference

Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats

31 March 2020

1 reference

Structure of the Extracellular Domain of Tie Receptor Tyrosine Kinases and Localization of the Angiopoietin-binding Epitope

31 March 2020

1 reference

Specific Induction of tie1 Promoter by Disturbed Flow in Atherosclerosis-Prone Vascular Niches and Flow-Obstructing Pathologies

31 March 2020

1 reference

Targeting exogenous genes to tumor angiogenesis by transplantation of genetically modified hematopoietic stem cells

31 March 2020

1 reference

Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors.

31 March 2020

1 reference

Angiopoietin-1 and -2 coiled coil domains mediate distinct homo-oligomerization patterns, but fibrinogen-like domains mediate ligand activity

31 March 2020

1 reference

Angiopoietins have distinct modular domains essential for receptor binding, dimerization and superclustering

31 March 2020

1 reference

Designed angiopoietin-1 variant, COMP-Ang1, protects against radiation-induced endothelial cell apoptosis

31 March 2020

1 reference

Functional inhibition of secreted angiopoietin: a novel role for angiopoietin 1 in coronary vessel patterning

31 March 2020

1 reference

Oligomerization and multimerization are critical for angiopoietin-1 to bind and phosphorylate Tie2.

31 March 2020

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Angiopoietin-1 induces sprouting angiogenesis in vitro

31 March 2020

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COMP-Ang1: a designed angiopoietin-1 variant with nonleaky angiogenic activity

31 March 2020

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COMP-angiopoietin-1 promotes wound healing through enhanced angiogenesis, lymphangiogenesis, and blood flow in a diabetic mouse model

31 March 2020

1 reference

Cell type-specific expression of angiopoietin-1 and angiopoietin-2 suggests a role in glioblastoma angiogenesis

31 March 2020

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Angiopoietin switching regulates angiogenesis and progression of human hepatocellular carcinoma

31 March 2020

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Angiopoietin-1, unlike angiopoietin-2, is incorporated into the extracellular matrix via its linker peptide region

31 March 2020

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New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF.

31 March 2020

1 reference

Thrombin induces increased expression and secretion of angiopoietin-2 from human umbilical vein endothelial cells

31 March 2020

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Regulation of angiopoietin-2 mRNA levels in bovine microvascular endothelial cells by cytokines and hypoxia.

31 March 2020

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Hypoxia and vascular endothelial growth factor selectively up-regulate angiopoietin-2 in bovine microvascular endothelial cells

31 March 2020

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Hypoxia-inducible angiopoietin-2 expression is mimicked by iodonium compounds and occurs in the rat brain and skin in response to systemic hypoxia and tissue ischemia

31 March 2020

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Integration of flow-dependent endothelial phenotypes by Kruppel-like factor 2

31 March 2020

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Expression of angiopoietin-2 in endothelial cells is controlled by positive and negative regulatory promoter elements

31 March 2020

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Excess circulating angiopoietin-2 may contribute to pulmonary vascular leak in sepsis in humans

31 March 2020

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The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies

31 March 2020

1 reference

Angiopoietins: a link between angiogenesis and inflammation.

31 March 2020

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Angiopoietin-1 induces endothelial cell sprouting through the activation of focal adhesion kinase and plasmin secretion

31 March 2020

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Angiopoietin-1 inhibits endothelial cell apoptosis via the Akt/survivin pathway

31 March 2020

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The endothelial receptor tyrosine kinase Tie1 activates phosphatidylinositol 3-kinase and Akt to inhibit apoptosis.

31 March 2020

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Akt is a major angiogenic mediator downstream of the Ang1/Tie2 signaling pathway

31 March 2020

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Angiopoietin-1 modulates endothelial cell function and gene expression via the transcription factor FKHR (FOXO1).

31 March 2020

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Regulation of Ang2 release by PTEN/PI3-kinase/Akt in lung microvascular endothelial cells

31 March 2020

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Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration.

31 March 2020

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Angiopoietin 1 is mitogenic for cultured endothelial cells

31 March 2020

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Angiopoietin-1 regulates endothelial cell survival through the phosphatidylinositol 3'-Kinase/Akt signal transduction pathway

31 March 2020

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Dok-R plays a pivotal role in angiopoietin-1-dependent cell migration through recruitment and activation of Pak.

31 March 2020

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Angiopoietin-1 prevents VEGF-induced endothelial permeability by sequestering Src through mDia.

31 March 2020

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ABIN-2 protects endothelial cells from death and has a role in the antiapoptotic effect of angiopoietin-1

31 March 2020

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The antiinflammatory endothelial tyrosine kinase Tie2 interacts with a novel nuclear factor-kappaB inhibitor ABIN-2.

31 March 2020

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Angiopoietin-regulated recruitment of vascular smooth muscle cells by endothelial-derived heparin binding EGF-like growth factor

31 March 2020

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Hepatocyte growth factor mediates angiopoietin-induced smooth muscle cell recruitment

31 March 2020

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Induction of pulmonary hypertension by an angiopoietin 1/TIE2/serotonin pathway

31 March 2020

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Recombinant angiopoietin-1 restores higher-order architecture of growing blood vessels in mice in the absence of mural cells.

31 March 2020

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Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contacts

31 March 2020

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Differential function of Tie2 at cell-cell contacts and cell-substratum contacts regulated by angiopoietin-1

31 March 2020

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Functional interaction of vascular endothelial-protein-tyrosine phosphatase with the angiopoietin receptor Tie-2

31 March 2020

1 reference

Transcriptional and post‐translation regulation of the Tiel receptor by fluid shear stress changes in vascular endothelial cells

31 March 2020

1 reference

Regulated proteolytic processing of Tie1 modulates ligand responsiveness of the receptor-tyrosine kinase Tie2.

31 March 2020

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Activation of the orphan endothelial receptor Tie1 modifies Tie2-mediated intracellular signaling and cell survival

31 March 2020

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Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2

31 March 2020

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The Tie-2 ligand angiopoietin-2 destabilizes quiescent endothelium through an internal autocrine loop mechanism

31 March 2020

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Angiopoietin-2 functions as an autocrine protective factor in stressed endothelial cells

31 March 2020

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Autocrine VEGF signaling is required for vascular homeostasis

31 March 2020

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Angiopoietin-2 at high concentration can enhance endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway

31 March 2020

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Signaling and regulation of endothelial cell survival by angiopoietin-2.

31 March 2020

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Biological action of angiopoietin-2 in a fibrin matrix model of angiogenesis is associated with activation of Tie2.

31 March 2020

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EphB ligand, ephrinB2, suppresses the VEGF- and angiopoietin 1-induced Ras/mitogen-activated protein kinase pathway in venous endothelial cells

31 March 2020

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Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche

31 March 2020

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Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment

31 March 2020

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Angiopoietin-1-induced PI3-kinase activation prevents neuronal apoptosis.

31 March 2020

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Angiopoietin-1 promotes neurite outgrowth from dorsal root ganglion cells positive for Tie-2 receptor

31 March 2020

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Vascular-specific growth factor angiopoietin 1 is involved in the organization of neuronal processes

31 March 2020

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Direct cell adhesion to the angiopoietins mediated by integrins

31 March 2020

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Angiopoietin-1 promotes cardiac and skeletal myocyte survival through integrins

31 March 2020

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Angiopoietin-2 stimulates breast cancer metastasis through the alpha(5)beta(1) integrin-mediated pathway

31 March 2020

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Angiopoietin-1 promotes LYVE-1-positive lymphatic vessel formation.

31 March 2020

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Angiopoietin-1 promotes lymphatic sprouting and hyperplasia.

31 March 2020

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Identification of vascular lineage-specific genes by transcriptional profiling of isolated blood vascular and lymphatic endothelial cells

31 March 2020

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Fatal bilateral chylothorax in mice lacking the integrin alpha9beta1.

31 March 2020

1 reference

Spatial and temporal role of the apelin/APJ system in the caliber size regulation of blood vessels during angiogenesis

31 March 2020

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Interaction of the TEK and TIE receptor tyrosine kinases during cardiovascular development.

31 March 2020

1 reference

12 December 2020

Distinct rat genes with related profiles of expression define a TIE receptor tyrosine kinase family

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12 December 2020

Angiopoietin-1 inhibits vascular permeability, angiogenesis, and growth of hepatic colon cancer tumors

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12 December 2020

Regulation of tie receptor expression on human endothelial cells by protein kinase C-mediated release of soluble tie.

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12 December 2020

Angiopoietin 2 expression in the retina: upregulation during physiologic and pathologic neovascularization

1 reference

12 December 2020

[Expression and significance of Ang1, Ang2 and receptor Tie2 in hemangioma]

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12 December 2020

The effects of angiopoietin-1 and -2 on tumor growth and angiogenesis in human colon cancer

1 reference

12 December 2020

Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases.

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12 December 2020

Tumor-derived vascular endothelial growth factor up-regulates angiopoietin-2 in host endothelium and destabilizes host vasculature, supporting angiogenesis in ovarian cancer

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12 December 2020

Admission angiopoietin levels in children with septic shock.

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12 December 2020

Analysis of blood vessel maturation processes during cyclic ovarian angiogenesis

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12 December 2020

Tie1, a receptor tyrosine kinase essential for vascular endothelial cell integrity, is not critical for the development of hematopoietic cells.

1 reference

12 December 2020

Expression of tie-2, a member of a novel family of receptor tyrosine kinases, in the endothelial cell lineage

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12 December 2020

Angiopoietin-2 is related to tumor angiogenesis in gastric carcinoma: possible in vivo regulation via induction of proteases

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12 December 2020

Targeting tumor angiogenesis with adenovirus-delivered anti-Tie-2 intrabody

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12 December 2020

tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors

1 reference

12 December 2020

Hepatic expression, synthesis and secretion of a novel fibrinogen/angiopoietin-related protein that prevents endothelial-cell apoptosis

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12 December 2020

Enhanced expression of the tie receptor tyrosine kinase mesenger RNA in the vascular endothelium of metastatic melanomas

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12 December 2020

Host-derived angiopoietin-2 affects early stages of tumor development and vessel maturation but is dispensable for later stages of tumor growth

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12 December 2020

Two independent mechanisms essential for tumor angiogenesis: inhibition of human melanoma xenograft growth by interfering with either the vascular endothelial growth factor receptor pathway or the Tie-2 pathway

1 reference

12 December 2020

Inflammatory cytokines and vascular endothelial growth factor stimulate the release of soluble tie receptor from human endothelial cells via metalloprotease activation

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12 December 2020

Identifiers

DOI

10.1038/NRM2639

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20 August 2017

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