(Q30710689)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10361252%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

review article

1 reference

title

Perforin-dependent nuclear targeting of granzymes: A central role in the nuclear events of granule-exocytosis-mediated apoptosis? (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10361252%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10361252%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

author name string

E J Blink

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10361252%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

D A Jans

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10361252%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

publication date

1 June 1999

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10361252%20AND%20SRC:MED&resulttype=core&format=json

Immunology & Cell Biology

8 December 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10361252%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

volume

77

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10361252%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10361252%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

page(s)

206-215

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10361252%20AND%20SRC:MED&resulttype=core&format=json

Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B.

8 December 2019

cites work

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

Molecular mechanisms in cell-mediated cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

Nuclear events of apoptosis in vitro in cell-free mitotic extracts: a model system for analysis of the active phase of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

The nuclear matrix and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

Apoptosis: molecular regulation of cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

Caspases: killer proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

The apoptotic cysteine protease CPP32.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

Protease activation during apoptosis: death by a thousand cuts?

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

Cell-mediated cytotoxicity: contact and secreted factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

Target cell apoptosis induced by cytotoxic T cells and natural killer cells involves synergy between the pore-forming protein, perforin, and the serine protease, granzyme B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

Granzymes: exogenous proteinases that induce target cell apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

Nuclear transport of granzyme B (fragmentin-2). Dependence of perforin in vivo and cytosolic factors in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

BCL-2 blocks perforin-induced nuclear translocation of granzymes concomitant with protection against the nuclear events of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

Perforin-dependent nuclear entry of granzyme B precedes apoptosis, and is not a consequence of nuclear membrane dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

Granzyme B (GraB) autonomously crosses the cell membrane and perforin initiates apoptosis and GraB nuclear localization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

Perforin and lymphocyte-mediated cytolysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

Efficient Nuclear Targeting of Granzyme B and the Nuclear Consequences of Apoptosis Induced by Granzyme B and Perforin Are Caspase-dependent, but Cell Death Is Caspase-independent

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

Interleukin-1 beta-converting enzyme-like protease cleaves DNA-dependent protein kinase in cytotoxic T cell killing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

Recombinant human granzyme A binds to two putative HLA-associated proteins and cleaves one of them

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

Granzyme A released upon stimulation of cytotoxic T lymphocytes activates the thrombin receptor on neuronal cells and astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

Residual cytotoxicity and granzyme K expression in granzyme A-deficient cytotoxic lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

A null mutation in the perforin gene impairs cytolytic T lymphocyte- and natural killer cell-mediated cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

Natural killer and lymphokine-activated killer cells require granzyme B for the rapid induction of apoptosis in susceptible target cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

In vitro- and ex vivo-derived cytolytic leukocytes from granzyme A x B double knockout mice are defective in granule-mediated apoptosis but not lysis of target cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

Regulation of protein transport to the nucleus: central role of phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

The regulation of protein transport to the nucleus by phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

Sequence requirements for nuclear location of simian virus 40 large-T antigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

A short amino acid sequence able to specify nuclear location

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

Construction and characterization of an SV40 mutant defective in nuclear transport of T antigen.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

Distinct functions for the two importin subunits in nuclear protein import

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors, and nucleoporins

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

The GTP-binding protein Ran/TC4 is required for protein import into the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelope

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

Dominant-negative mutants of importin-beta block multiple pathways of import and export through the nuclear pore complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

21 January 2018

Nuclear protein import

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

Nuclear import can be separated into distinct steps in vitro: nuclear pore binding and translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

p34cdc2-mediated phosphorylation at T124 inhibits nuclear import of SV-40 T antigen proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

Visualization of transport-related configurations of the nuclear pore transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

Protein import through the nuclear pore complex is a multistep process

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

Localization of a myosin heavy chain-like polypeptide to Drosophila nuclear pore complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

The cAMP-dependent protein kinase site (Ser312) enhances dorsal nuclear import through facilitating nuclear localization sequence/importin interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

Importin beta recognizes parathyroid hormone-related protein with high affinity and mediates its nuclear import in the absence of importin alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

Mutual exclusivity of DNA binding and nuclear localization signal recognition by the yeast transcription factor GAL4: implications for nonviral DNA delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

CRM1 is an export receptor for leucine-rich nuclear export signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

A nuclear localization domain in the hnRNP A1 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

A novel receptor-mediated nuclear protein import pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

The K nuclear shuttling domain: a novel signal for nuclear import and nuclear export in the hnRNP K protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

Nuclear localization signal-independent and importin/karyopherin-independent nuclear import of beta-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

The HIV-1 Tat nuclear localization sequence confers novel nuclear import properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

A protein kinase-A recognition sequence is structurally linked to transformation by p59v-rel and cytoplasmic retention of p68c-rel

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

NF-kappa B: a pleiotropic mediator of inducible and tissue-specific gene control

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

Selective nuclear transport of the Drosophila morphogen dorsal can be established by a signaling pathway involving the transmembrane protein Toll and protein kinase A

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

Binding of granzyme B in the nucleus of target cells. Recognition of an 80-kilodalton protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

Localization of granzyme B in the nucleus. A putative role in the mechanism of cytotoxic lymphocyte-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

The target cell nucleus is not required for cell-mediated granzyme- or Fas-based cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

Depletion of calcium from the lumen of endoplasmic reticulum reversibly inhibits passive diffusion and signal-mediated transport into the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

Conformational states of the nuclear pore complex induced by depletion of nuclear Ca2+ stores.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

c-myc and bcl-2 modulate p53 function by altering p53 subcellular trafficking during the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

Activation of cyclin A-dependent protein kinases during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

Possible involvement of CTL granule proteases in target cell DNA breakdown

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

Induction of target cell DNA release by the cytotoxic T lymphocyte granule protease granzyme A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

New Paradigm for Lymphocyte Granule-mediated Cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1711.1999.00817.X

10.1046/J.1440-1711.1999.00817.X

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10361252%20AND%20SRC:MED&resulttype=core&format=json

release_twoa53ga2jbulibumghlkilz64

8 December 2019

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/twoa53ga2jbulibumghlkilz64

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference