(Q30765200)

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The integration of data on physico-chemical properties, in vitro-derived toxicity data and physiologically based kinetic and dynamic as modelling a tool in hazard and risk assessment. A commentary.

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17 December 2019

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The integration of data on physico-chemical properties, in vitro-derived toxicity data and physiologically based kinetic and dynamic as modelling a tool in hazard and risk assessment. A commentary (English)

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Europe PubMed Central

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17 December 2019

Bas J Blaauboer

1

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17 December 2019

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B J Blaauboer

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26 June 2017

publication date

1 February 2003

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17 December 2019

Toxicology Letters

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17 December 2019

138

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17 December 2019

1-2

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17 December 2019

161-171

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17 December 2019

Physiological modelling of organic compounds

1 reference

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Physiologically based pharmacokinetics and the risk assessment process for methylene chloride.

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Tissue dosimetry, pharmacokinetic modeling, and interspecies scaling factors

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Applying simulation modeling to problems in toxicology and risk assessment--a short perspective.

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Quantitative structure-Activity relationships for skin irritation and corrosivity of neutral and electrophilic organic chemicals

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Quantitative structure-activity relationships (QSARs) for skin corrosivity of organic acids, bases and phenols: Principal components and neural network analysis of extended datasets

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Prediction of toxicity from chemical structure

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The use of in vitro cytotoxicity measurements in QSAR methods for the prediction of the skin corrosivity potential of acids.

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Computational predictive programs (expert systems) in toxicology

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7 January 2021

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Toxicodynamic modelling and the interpretation of in vitro toxicity data

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The Integrated Use of Alternative Methods in Toxicological Risk Evaluation - ECVAM Integrated Testing Strategies Task Force Report 1

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Coupling of computer modeling with in vitro methodologies to reduce animal usage in toxicity testing.

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7 January 2021

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Use of physiologically based pharmacokinetic modeling to investigate individual versus population risk

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The use of genetically engineered cells for assessing CYP2D6-related polymorphic effects

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Simulation of toluene kinetics in the rat by a physiologically based pharmacokinetic model with application of biotransformation parameters derived independently in vitro and in vivo.

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7 January 2021

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An Integrated Approach to the Prediction of Systemic Toxicity using Computer-based Biokinetic Models and Biological In vitro Test Methods: Overview of a Prevalidation Study Based on the ECITTS Project.

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Estimation of systemic toxicity of acrylamide by integration of in vitro toxicity data with kinetic simulations.

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7 January 2021

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A quantitative property-property relationship (QPPR) approach to estimate in vitro tissue-blood partition coefficients of organic chemicals in rats and humans.

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7 January 2021

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Kinetics of propylene oxide metabolism in microsomes and cytosol of different organs from mouse, rat, and humans

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7 January 2021

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The role of mechanistic toxicology in test method validation.

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7 January 2021

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QSAR modeling of oxidative stress in vitro following hepatocyte exposures to halogenated methanes

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7 January 2021

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The use of genomics technology to investigate gene expression changes in cultured human liver cells

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7 January 2021

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PBPK model for butadiene metabolism to epoxides: quantitative species differences in metabolism

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7 January 2021

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Molecular modelling of the human cytochrome P450 isoform CYP2A6 and investigations of CYP2A substrate selectivity

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7 January 2021

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Acceptable daily intake: Inception, evolution, and application

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7 January 2021

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In vitro human tissue models in risk assessment: report of a consensus-building workshop

1 reference

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7 January 2021

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Empirical relations predicting human and rat tissue:air partition coefficients of volatile organic compounds

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7 January 2021

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A QSAR model for the eye irritation of cationic surfactants.

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7 January 2021

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A biologically-based algorithm for predicting human tissue: blood partition coefficients of organic chemicals.

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7 January 2021

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A tissue composition-based algorithm for predicting tissue:air partition coefficients of organic chemicals.

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7 January 2021

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Incorporation of in vitro enzyme data into the physiologically-based pharmacokinetic (PB-PK) model for methylene chloride: implications for risk assessment

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Computer prediction of possible toxic action from chemical structure: an update on the DEREK system.

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Predicting reductive transformation rates of halogenated aliphatic compounds using different QSAR approaches

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Computer-modeling-based QSARs for analyzing experimental data on biotransformation and toxicity

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A proposed approach to study the toxicology of complex mixtures of petroleum products: the integrated use of QSAR, lumping analysis and PBPK/PD modeling

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The benchmark approach applied to a 28-day toxicity study with Rhodorsil Silane in rats. the impact of increasing the number of dose groups

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Identifiers

10.1016/S0378-4274(02)00367-3

1 reference

Europe PubMed Central

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17 December 2019

1 reference

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17 December 2019

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