(Q78020603)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10413191%20AND%20SRC:MED&resulttype=core&format=json

10 December 2019

title

Molecular modelling of the human cytochrome P450 isoform CYP2A6 and investigations of CYP2A substrate selectivity (English)

1 reference

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10 December 2019

author name string

D F Lewis

1

1 reference

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10 December 2019

M Dickins

2

1 reference

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10 December 2019

B G Lake

3

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10 December 2019

P J Eddershaw

4

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10 December 2019

M H Tarbit

5

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10 December 2019

P S Goldfarb

6

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10 December 2019

publication date

1 March 1999

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10 December 2019

number of pages

33

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inferred from page(s)

published in

Toxicology

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10 December 2019

volume

133

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10 December 2019

issue

1

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10 December 2019

page(s)

1-33

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Structural invariants in protein folding

10 December 2019

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Human cytochromes P450: problems and prospects

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7 January 2021

CYP2A6 gene polymorphism and risk of liver cancer and cirrhosis

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7 January 2021

A single amino acid substitution (Leu160His) in cytochrome P450 CYP2A6 causes switching from 7-hydroxylation to 3-hydroxylation of coumarin

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Site-directed mutagenesis of cytochrome P450s CYP2A1 and CYP2A2: influence of the distal helix on the kinetics of testosterone hydroxylation

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The structure, function, and regulation of cytochrome P450 2A enzymes

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Site-directed mutagenesis of mouse steroid 7 alpha-hydroxylase (cytochrome P-450(7) alpha): role of residue-209 in determining steroid-cytochrome P-450 interaction

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7 January 2021

Multiple steroid-binding orientations: alteration of regiospecificity of dehydroepiandrosterone 2- and 7-hydroxylase activities of cytochrome P-450 2a-5 by mutation of residue 209.

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7 January 2021

Identification of the cytochrome P450 isoforms involved in the O-demethylation of 4-nitroanisole in human liver microsomes

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7 January 2021

Structural alteration of mouse P450coh by mutation of glycine-207 to proline: spin equilibrium, enzyme kinetics, and heat sensitivity

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7 January 2021

Competitive inhibition of coumarin 7-hydroxylation by pilocarpine and its interaction with mouse CYP 2A5 and human CYP 2A6

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7 January 2021

The inhibition of CYP enzymes in mouse and human liver by pilocarpine

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7 January 2021

Comparison of the hepatotoxicity of coumarin in the rat, mouse, and Syrian hamster: a dose and time response study

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7 January 2021

Comparison of the metabolism and disposition of [3-14C]coumarin in the rat and marmoset (Callithrix jacchus)

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7 January 2021

Metabolism of [3-14C]coumarin to polar and covalently bound products by hepatic microsomes from the rat, Syrian hamster, gerbil and humans

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7 January 2021

Identification of o-hydroxyphenylacetaldehyde as a major metabolite of coumarin in rat hepatic microsomes

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7 January 2021

Studies on the acute effects of coumarin and some coumarin derivatives in the rat

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7 January 2021

The CYP2 family: models, mutants and interactions

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7 January 2021

Molecular modelling of members of the P4502A subfamily: application to studies of enzyme specificity

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7 January 2021

Nitrosamine carcinogenesis: rodent assays, quantitative structure-activity relationships, and human risk assessment

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7 January 2021

The structure of the cytochrome p450BM-3 haem domain complexed with the fatty acid substrate, palmitoleic acid

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7 January 2021

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7 January 2021

Molecular characterization of the murine Coh locus: an amino acid difference at position 117 confers high and low coumarin 7-hydroxylase activity in P450coh

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7 January 2021

Differential inhibition of coumarin 7-hydroxylase activity in mouse and human liver microsomes

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7 January 2021

Identification of the human liver cytochrome P-450 responsible for coumarin 7-hydroxylase activity

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7 January 2021

Structural flexibility and functional versatility of cytochrome P450 and rapid evolution

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7 January 2021

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7 January 2021

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7 January 2021

Specificity of substrate and inhibitor probes for cytochrome P450s: evaluation of in vitro metabolism using cDNA-expressed human P450s and human liver microsomes

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7 January 2021

Species differences and interindividual variation in liver microsomal cytochrome P450 2A enzymes: effects on coumarin, dicumarol, and testosterone oxidation

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7 January 2021

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Cytochrome P450 species involved in the metabolism of quinoline

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7 January 2021

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7 January 2021

Hydrophilicity of polar amino acid side-chains is markedly reduced by flanking peptide bonds

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7 January 2021

Cytochrome P4502A5 expression and inducibility by phenobarbital is modulated by cAMP in mouse primary hepatocytes

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7 January 2021

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7 January 2021

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7 January 2021

Metabolism of coumarin and 7-ethoxycoumarin by rat, mouse, guinea pig, cynomolgus monkey and human precision-cut liver slices

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7 January 2021

Metabolism of [3-14C] coumarin by human liver microsomes

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7 January 2021

Sex and strain differences in mouse hepatic microsomal coumarin 7-hydroxylase activity

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7 January 2021

The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes

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7 January 2021

Cytochrome P450 2E1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialkylamines and tobacco-related nitrosamines in human liver microsomes

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7 January 2021

Genetic polymorphism of drug metabolizing enzymes: new mutations in CYP2D6 and CYP2A6 genes in Japanese

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7 January 2021

10.1016/S0300-483X(98)00149-8

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10413191%20AND%20SRC:MED&resulttype=core&format=json

10 December 2019

1 reference