(Q34429206)

2 August 2017

1 reference

title

Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors (English)

1 reference

2 August 2017

Rendic S

1

1 reference

PubMed ID

9187528

2 August 2017

Di Carlo FJ

series ordinal

2

1 reference

PubMed ID

9187528

2 August 2017

language of work or name

English

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publication date

1 February 1997

1 reference

2 August 2017

Drug Metabolism Reviews

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2 August 2017

29

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2 August 2017

1-2

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2 August 2017

413-580

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Clinical importance of hepatic cytochrome P450 in drug metabolism

2 August 2017

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Speculations on the substrate structure-activity relationship (SSAR) of cytochrome P450 enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

The role of cytochrome P450 enzymes in hepatic and extrahepatic human drug toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Cytochromes P450: their active-site structure and mechanism of oxidation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Oxygen and xenobiotic reductase activities of cytochrome P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

The P450 superfamily: updated listing of all genes and recommended nomenclature for the chromosomal loci

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Genetically engineered mammalian cells and applications

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Genetically engineered bacterial cells and applications.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Cytochromes P450 expression systems

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Study of coumarin metabolism by Chinese hamster lung fibroblasts expressing a human cytochrome P450 using H-nmr

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Genetic implications in the metabolism and toxicity of mycotoxins

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Role of human cytochromes P450 in the metabolic activation of chemical carcinogens and toxins

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Molecular modelling of cytochrome CYP1A1: a putative access channel explains differences in induction potency between the isomers benzo(a)pyrene and benzo(e)pyrene, and 2- and 4-acetylaminofluorene.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

In vitro methods for assessing human hepatic drug metabolism: their use in drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Induction of cytochrome P4501 as an indicator of potential chemical carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Molecular mechanisms of the hepatotoxicity caused by acetaminophen

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Expression of CYP1A1 gene in patients with lung cancer: evidence for cigarette smoke-induced gene expression in normal lung tissue and for altered gene regulation in primary pulmonary carcinomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Activation of trans-1,2-dihydro-1,2-dihydroxy-6-aminochrysene to genotoxic metabolites by rat and human cytochromes P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Biochemical individuality and its implications for drug and carcinogen metabolism: recent insights from acetyltransferase and cytochrome P4501A2 phenotyping and genotyping in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Caffeine as a metabolic probe: a comparison of the metabolic ratios used to assess CYP1A2 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Inhibitory potency of quinolone antibacterial agents against cytochrome P450IA2 activity in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Expression of modified human cytochrome P450 1A2 in Escherichia coli: stabilization, purification, spectral characterization, and catalytic activities of the enzyme.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Evaluation of triacetyloleandomycin, alpha-naphthoflavone and diethyldithiocarbamate as selective chemical probes for inhibition of human cytochromes P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

7,8-Benzoflavone stimulates the metabolic activation of aflatoxin B1 to mutagens by human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Interethnic difference in omeprazole's inhibition of diazepam metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Thiophene derivatives as new mechanism-based inhibitors of cytochromes P-450: inactivation of yeast-expressed human liver cytochrome P-450 2C9 by tienilic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Identification of human liver cytochrome P450 isoforms mediating secondary omeprazole metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Interindividual and interspecies variation in the metabolism of the hallucinogen 4-methoxyamphetamine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Catalytic activities of human debrisoquine 4-hydroxylase cytochrome P450 (CYP2D6) expressed in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

CYP2D6 phenotype determines the metabolic conversion of hydrocodone to hydromorphone.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Dextromethorphan: polymorphic serum pattern of the O-demethylated and didemethylated metabolites in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Characterization of a human liver cytochrome P-450 involved in the oxidation of debrisoquine and other drugs by using antibodies raised to the analogous rat enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Pharmacokinetics of N-propylajmaline in relation to polymorphic sparteine oxidation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Clinical enflurane metabolism by cytochrome P450 2E1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Induction of cytochrome P450 by toluene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Assessment of cytochrome P4502E1 induction in alcoholic patients by chlorzoxazone pharmacokinetics.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Expression of modified human cytochrome P450 2E1 in Escherichia coli, purification, and spectral and catalytic properties.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Noninvasive tests of CYP3A enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

The role of cytochrome P450 3A (CYP3A) isoform(s) in oxidative metabolism of testosterone and benzphetamine in human adult and fetal liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Human liver microsomal steroid metabolism: identification of the major microsomal steroid hormone 6 beta-hydroxylase cytochrome P-450 enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Regioselective biotransformation of midazolam by members of the human cytochrome P450 3A (CYP3A) subfamily.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Interaction between grapefruit juice and midazolam in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Midazolam should be avoided in patients receiving the systemic antimycotics ketoconazole or itraconazole.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Identification of the major human hepatic cytochrome P450 involved in activation and N-dechloroethylation of ifosfamide

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Genetic toxicology using human cell lines expressing human P-450.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Oral triazolam is potentially hazardous to patients receiving systemic antimycotics ketoconazole or itraconazole

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

The role of lipophilicity in the inhibition of polymorphic cytochrome P450IID6 oxidation by beta-blocking agents in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Inhibitors of imipramine metabolism by human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Metabolism of thioridazine by microsomal monooxygenases: relative roles of P450 and flavin-containing monooxygenase.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Human liver microsomes are efficient catalysts of 1,3-butadiene oxidation: evidence for major roles by cytochromes P450 2A6 and 2E1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Characterisation of the cytochrome P450 enzymes involved in the in vitro metabolism of granisetron

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Metabolism of a new local anesthetic, ropivacaine, by human hepatic cytochrome P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Steroidogenic enzymes: structure, function, and role in regulation of steroid hormone biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Inhibitors of P450-dependent steroid biosynthesis: from research to medical treatment.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

The effects of cimetidine on the oxidative metabolism of estradiol

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Risk of gynaecomastia associated with cimetidine, omeprazole, and other antiulcer drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Molecular biology of 11β-hydroxylase and 11β-hydroxysteroid dehydrogenase enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

The use of ketoconazole as an inhibitor of steroid production

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Ketoconazole blocks adrenal steroidogenesis by inhibiting cytochrome P450-dependent enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Androgen formation by cytochrome P450 CYP17. Solvent isotope effect and pL studies suggest a role for protons in the regulation of oxene versus peroxide chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Cytochrome P-450 C21scc: one enzyme with two actions: hydroxylase and lyase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Inhibition of steroid 17 alpha-hydroxylase and C17,20-lyase in the human testis by epitestosterone

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Inhibition by omeprazole of adrenocortical response to ACTH: clinical studies and experiments on bovine adrenal cortex in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Oxylanosterols as modifiers of cholesterol biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Human cytochrome P450 enzyme selectivities in the oxidation of chlorinated benzenes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Effect of dexamethasone and cytochrome P450 inhibitors on the formation of 7 alpha-hydroxydehydroepiandrosterone by human adipose stromal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Cytochrome P450 CYP3A5 in the human anterior pituitary gland

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

The inhibition of CYP enzymes in mouse and human liver by pilocarpine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Inhibition of cyclosporine and tetrahydrocannabinol metabolism by cannabidiol in mouse and human microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Expression of xenobiotic-metabolizing cytochrome P450 forms in human full-term placenta

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

The ubiquitously expressed human CYP51 encodes lanosterol 14 alpha-demethylase, a cytochrome P450 whose expression is regulated by oxysterols.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Expression of CYP3A7, a human fetus-specific cytochrome P450, in cultured cells and in the hepatocytes of p53-knockout mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

The influence of the sparteine/debrisoquine genetic polymorphism on the disposition of dexfenfluramine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) by human cytochrome P450 1A2 and its inhibition by phenethyl isothiocyanate.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

The emerging role of cytochrome P450 3A in psychopharmacology

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Metabolic activation of the potent carcinogen dibenzo[a,h]anthracene by cDNA-expressed human cytochromes P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Molecular cloning and expression of CYP2J2, a human cytochrome P450 arachidonic acid epoxygenase highly expressed in heart

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Human cytochrome P450 mono-oxygenase system is suppressed by propofol

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Macrolide antibacterials. Drug interactions of clinical significance

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

In vitro studies on the metabolic activation of the furanopyridine L-754,394, a highly potent and selective mechanism-based inhibitor of cytochrome P450 3A4.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Inhibition of tolbutamide 4-methylhydroxylation by a series of non-steroidal anti-inflammatory drugs in V79-NH cells expressing human cytochrome P4502C10.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

Pharmacokinetic and pharmacodynamic interactions between diltiazem and quinidine.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539709037591

10.3109/03602539709037591

21 January 2018

Identifiers

DOI

1 reference

2 August 2017

1 reference

PubMed ID

9187528