(Q40817420)

24 September 2017

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title

In vitro methods for assessing human hepatic drug metabolism: their use in drug development (English)

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24 September 2017

Wrighton SA

1

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24 September 2017

Vandenbranden M

2

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24 September 2017

Stevens JC

3

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24 September 2017

Shipley LA

4

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24 September 2017

Ring BJ

5

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24 September 2017

Rettie AE

6

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24 September 2017

Cashman JR

7

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24 September 2017

language of work or name

English

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publication date

1 January 1993

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24 September 2017

published in

Drug Metabolism Reviews

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24 September 2017

volume

25

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24 September 2017

issue

4

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24 September 2017

page(s)

453-484

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The human hepatic cytochromes P450 involved in drug metabolism

24 September 2017

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Role of cytochromes P450 in drug metabolism and hepatotoxicity

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Glucuronidation and its Role in Regulation of Biological Activity of Drugs

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UDP-glucuronosyltransferases: a family of detoxifying enzymes

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Glutathione S-transferases: gene structure, regulation, and biological function

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Potential use of human tissues for toxicity research and testing.

21 January 2018

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The use of human liver for foreign compound metabolism and toxicity studies

21 January 2018

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21 January 2018

Human cytochromes P-450.

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In vitro forecasting of drugs that may interfere with codeine bioactivation

21 January 2018

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Ethnic differences in drug disposition and responsiveness

21 January 2018

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P450 enzymes. Inhibition mechanisms, genetic regulation and effects of liver disease

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Species differences in metabolism and pharmacokinetics: are we close to an understanding?

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The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature

21 January 2018

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Human dioxin-inducible cytochrome P1-450: complementary DNA and amino acid sequence

21 January 2018

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A form of cytochrome P450 in man, orthologous to form d in the rat, catalyses the O-deethylation of phenacetin and is inducible by cigarette smoking

21 January 2018

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Furafylline is a potent and selective inhibitor of cytochrome P450IA2 in man.

21 January 2018

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Isolation and characterization of a cytochrome P450 of the IIA subfamily from human liver microsomes

21 January 2018

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cDNA cloning and sequence and cDNA-directed expression of human P450 IIB1: identification of a normal and two variant cDNAs derived from the CYP2B locus on chromosome 19 and differential expression of the IIB mRNAs in human liver

21 January 2018

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Purification of a human liver cytochrome P-450 immunochemically related to several cytochromes P-450 purified from untreated rats

21 January 2018

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Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily

21 January 2018

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Metabolism of retinol and retinoic acid by human liver cytochrome P450IIC8

21 January 2018

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Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: a role for P-4502C9 in the etiology of (S)-warfarin-drug interactions

21 January 2018

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In vitro inhibition studies of tolbutamide hydroxylase activity of human liver microsomes by azoles, sulphonamides and quinolines

21 January 2018

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Induction of polymorphic 4'-hydroxylation of S-mephenytoin by rifampicin

21 January 2018

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The genetic polymorphism of debrisoquine/sparteine metabolism-molecular mechanisms

21 January 2018

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Molecular genetics of the debrisoquin-sparteine polymorphism

21 January 2018

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The specificity of inhibition of debrisoquine 4-hydroxylase activity by quinidine and quinine in the rat is the inverse of that in man.

21 January 2018

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Cytochrome P450IIE1: roles in nitrosamine metabolism and mechanisms of regulation

21 January 2018

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Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects

21 January 2018

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Purification and characterization of ethanol-inducible human hepatic cytochrome P-450HLj

21 January 2018

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Characterization of ethanol-inducible human liver N-nitrosodimethylamine demethylase

21 January 2018

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Identification of an inducible form of cytochrome P-450 in human liver

21 January 2018

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Human liver microsomal steroid metabolism: identification of the major microsomal steroid hormone 6 beta-hydroxylase cytochrome P-450 enzyme

21 January 2018

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Comparison of urinary 6-beta-cortisol and the erythromycin breath test as measures of hepatic P450IIIA (CYP3A) activity

21 January 2018

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Isolation and characterization of human fetal liver cytochrome P450HLp2: a third member of the P450III gene family

21 January 2018

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Flavin-containing monooxygenases: catalytic mechanism and substrate specificities

21 January 2018

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The flavin-containing monooxygenase expressed in pig liver: primary sequence, distribution, and evidence for a single gene

21 January 2018

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Metabolism of nicotine by human liver microsomes: stereoselective formation of trans-nicotine N'-oxide

21 January 2018

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Molecular cloning of the flavin-containing monooxygenase (form II) cDNA from adult human liver

21 January 2018

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Cloning, primary sequence and chromosomal localization of human FMO2, a new member of the flavin-containing mono-oxygenase family

21 January 2018

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A genetic polymorphism of the N-oxidation of trimethylamine in humans

21 January 2018

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Methyltransferase pharmacogenetics

21 January 2018

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Metabolism of ciamexon by human liver microsomes: an investigation into the formation of stable, chemically reactive and cytotoxic metabolites

21 January 2018

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21 January 2018

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21 January 2018

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The effect of selective serotonin re-uptake inhibitors on cytochrome P4502D6 (CYP2D6) activity in human liver microsomes

21 January 2018

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Glucuronidation of 3'-azido-3'-deoxythymidine: human and rat enzyme specificity

21 January 2018

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Nicotine pharmacokinetics and its application to intake from smoking

21 January 2018

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Recombinant DNA approaches for the development of metabolic systems used in in vitro toxicology

21 January 2018

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Techniques for pharmacological and toxicological studies with isolated hepatocyte suspensions

21 January 2018

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Comparative drug metabolism of diazepam in hepatocytes isolated from man, rat, monkey and dog.

21 January 2018

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Thawed human hepatocytes in primary culture

21 January 2018

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10.3109/03602539308993982

21 January 2018

Identifiers

DOI

1 reference

24 September 2017

1 reference