(Q30819299)

26 June 2017

Combinatorial chemistry and high-throughput screening in drug discovery: different strategies and formats (English)

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high-throughput screening

26 June 2017

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Seneci P

1

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PubMed ID

11865648

26 June 2017

Miertus S

series ordinal

2

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26 June 2017

1 January 2000

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26 June 2017

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26 June 2017

5

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26 June 2017

75-89

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26 June 2017

2

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Structure and inhibition of plasmepsin II, a hemoglobin-degrading enzyme from Plasmodium falciparum

26 June 2017

1 reference

12 December 2020

Potent, low-molecular-weight non-peptide inhibitors of malarial aspartyl protease plasmepsin II.

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12 December 2020

Cloning, expression and pharmacological characterization of a human glutamate receptor: hGluR4

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12 December 2020

A drug that facilitates glutamatergic transmission reduces exploratory activity and improves performance in a learning-dependent task

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12 December 2020

Facilitation of glutamate receptors enhances memory

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12 December 2020

Modulation of AMPA/kainate receptors by analogues of diazoxide and cyclothiazide in thin slices of rat hippocampus.

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12 December 2020

High-throughput screening: new technology for the 21st century

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12 December 2020

Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors

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12 December 2020

Benzothiadiazides inhibit rapid glutamate receptor desensitization and enhance glutamatergic synaptic currents.

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12 December 2020

Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution

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12 December 2020

Comprehensive survey of combinatorial library synthesis: 1999.

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12 December 2020

Diversity screening versus focussed screening in drug discovery

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12 December 2020

High-diversity combinatorial libraries

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12 December 2020

Piracetam and other structurally related nootropics

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12 December 2020

New 4-point pharmacophore method for molecular similarity and diversity applications: overview of the method and applications, including a novel approach to the design of combinatorial libraries containing privileged substructures

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12 December 2020

Expedient method for the solid-phase synthesis of aspartic acid protease inhibitors directed toward the generation of libraries

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12 December 2020

(+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo[5, 6]cyclohepta[1,2-b]- pyridin-11(R)-yl)-1-piperidinyl]-2-oxo-ethyl]-1-piperidinecarboxamid e (SCH-66336): a very potent farnesyl protein transferase inhibitor as a novel antitumor agent

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12 December 2020

7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide (IDRA 21), a congener of aniracetam, potently abates pharmacologically induced cognitive impairments in patas monkeys

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12 December 2020

Biarylpropylsulfonamides as novel, potent potentiators of 2-amino-3- (5-methyl-3-hydroxyisoxazol-4-yl)- propanoic acid (AMPA) receptors

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12 December 2020

Aniracetam. An overview of its pharmacodynamic and pharmacokinetic properties, and a review of its therapeutic potential in senile cognitive disorders

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12 December 2020

Successful Virtual Screening of a Chemical Database for Farnesyltransferase Inhibitor Leads

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12 December 2020

Structure-based design and combinatorial chemistry yield low nanomolar inhibitors of cathepsin D.

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12 December 2020

Evidence that a positive modulator of AMPA-type glutamate receptors improves delayed recall in aged humans.

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12 December 2020

Psychological effects of a drug that facilitates brain AMPA receptors.

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12 December 2020

Syntheses and absolute structures of novel protein farnesyltransferase inhibitors, kurasoins A and B

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12 December 2020

Identifiers

DOI

10.1023/A:1013824317218

1 reference

PubMed ID

11865648

Dimensions Publication ID

26 June 2017

0 references

1 reference

PubMed ID

11865648