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Poly(ADP-ribose) polymerase: killer or conspirator? The 'suicide hypothesis' revisited
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
11879679
retrieved
26 June 2017
review article
1 reference
stated in
Europe PubMed Central
title
Poly(ADP-ribose) polymerase: killer or conspirator? The 'suicide hypothesis' revisited
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
11879679
retrieved
26 June 2017
main subject
suicide
0 references
author name string
Alberto Chiarugi
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
11879679
retrieved
26 June 2017
publication date
1 March 2002
1 reference
stated in
Europe PubMed Central
PubMed ID
11879679
retrieved
26 June 2017
published in
Trends in Pharmacological Sciences
1 reference
stated in
Europe PubMed Central
PubMed ID
11879679
retrieved
26 June 2017
volume
23
1 reference
stated in
Europe PubMed Central
PubMed ID
11879679
retrieved
26 June 2017
page(s)
122-129
1 reference
stated in
Europe PubMed Central
PubMed ID
11879679
retrieved
26 June 2017
issue
3
1 reference
stated in
Europe PubMed Central
PubMed ID
11879679
retrieved
26 June 2017
cites work
Functions of poly(ADP-ribose) polymerase (PARP) in DNA repair, genomic integrity and cell death
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https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
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7 January 2021
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inferred from DOI database lookup
Poly(ADP-ribose) polymerase-1: what have we learned from the deficient mouse model?
1 reference
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https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
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7 January 2021
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Role of poly(ADP-ribose) synthetase in inflammation and ischaemia-reperfusion
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reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
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7 January 2021
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Poly (ADP-ribose) polymerase, nitric oxide and cell death
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
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7 January 2021
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The world according to PARP.
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https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
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7 January 2021
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Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozocin.
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reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
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7 January 2021
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Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation
1 reference
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https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
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7 January 2021
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Role of poly(ADP-ribose)synthetase in inflammation
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reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
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7 January 2021
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Resistance to endotoxic shock as a consequence of defective NF-kappaB activation in poly (ADP-ribose) polymerase-1 deficient mice
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reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
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7 January 2021
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Protection against hemorrhagic shock in mice genetically deficient in poly(ADP-ribose)polymerase
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reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
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7 January 2021
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Poly(ADP-ribose) polymerase-1 in the nervous system
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https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
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7 January 2021
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Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
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7 January 2021
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Poly(ADP-ribose) polymerase null mouse cells synthesize ADP-ribose polymers
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
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7 January 2021
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inferred from DOI database lookup
NAD(+) consumption in carcinogen-treated hamster cells overexpressing a dominant negative mutant of poly(ADP-ribose) polymerase
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reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
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7 January 2021
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Mechanisms of endothelial cell ATP depletion after oxidant injury
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https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
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7 January 2021
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ATP for the DNA ligation step in base excision repair is generated from poly(ADP-ribose).
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
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7 January 2021
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Overexpression of human poly(ADP-ribose) polymerase in transfected hamster cells leads to increased poly(ADP-ribosyl)ation and cellular sensitization to gamma irradiation
1 reference
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https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
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7 January 2021
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Effect of transient focal ischemia of mouse brain on energy state and NAD levels: no evidence that NAD depletion plays a major role in secondary disturbances of energy metabolism
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
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7 January 2021
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inferred from DOI database lookup
Characterization of sPARP-1. An alternative product of PARP-1 gene with poly(ADP-ribose) polymerase activity independent of DNA strand breaks.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
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7 January 2021
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PARP-2, A novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase
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reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
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7 January 2021
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inferred from DOI database lookup
A human poly(ADP-ribose) polymerase gene family (ADPRTL): cDNA cloning of two novel poly(ADP-ribose) polymerase homologues
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
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7 January 2021
based on heuristic
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Tankyrase promotes telomere elongation in human cells
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https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
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7 January 2021
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Tankyrase is a golgi-associated mitogen-activated protein kinase substrate that interacts with IRAP in GLUT4 vesicles
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
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7 January 2021
based on heuristic
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Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14
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https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
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7 January 2021
based on heuristic
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TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
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7 January 2021
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The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase
1 reference
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https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
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7 January 2021
based on heuristic
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Poly(ADP-ribosyl)ation basally activated by DNA strand breaks reflects glutamate-nitric oxide neurotransmission
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
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7 January 2021
based on heuristic
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A fast signal-induced activation of Poly(ADP-ribose) polymerase: a novel downstream target of phospholipase c.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
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7 January 2021
based on heuristic
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Phosphorylation of poly(ADP-ribose)polymerase protein in human peripheral lymphocytes stimulated with phytohemagglutinin
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
A cellular survival switch: poly(ADP-ribosyl)ation stimulates DNA repair and silences transcription
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
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7 January 2021
based on heuristic
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A cellular defense pathway regulating transcription through poly(ADP-ribosyl)ation in response to DNA damage
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
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7 January 2021
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Association of poly(adenosine diphosphate ribosylated) nucleosomes with transcriptionally active and inactive regions of chromatin
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
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7 January 2021
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inferred from DOI database lookup
Poly(ADP-ribose) polymerase enhances activator-dependent transcription in vitro
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reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
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7 January 2021
based on heuristic
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Involvement of poly (ADP-ribose)-polymerase in the Pax-6 gene regulation in neuroretina.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
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7 January 2021
based on heuristic
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PolyADP-ribose polymerase is a coactivator for AP-2-mediated transcriptional activation.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
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7 January 2021
based on heuristic
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Interaction of Oct-1 and automodification domain of poly(ADP-ribose) synthetase
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
A role of poly (ADP-ribose) polymerase in NF-kappaB transcriptional activation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Poly(ADP-ribosyl)ation is required for p53-dependent signal transduction induced by radiation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
A role for poly(ADP-ribose) polymerase in the transcriptional regulation of the melanoma growth stimulatory activity (CXCL1) gene expression
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
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7 January 2021
based on heuristic
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Amelioration of Diabetes Mellitus in Partially Depancreatized Rats by Poly(ADP-ribose) Synthetase Inhibitors: Evidence of Islet B-Cell Regeneration
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Poly(ADP-ribose) polymerase binds with transcription enhancer factor 1 to MCAT1 elements to regulate muscle-specific transcription
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Multiprotein complex formation at the beta myosin heavy chain distal muscle CAT element correlates with slow muscle expression but not mechanical overload responsiveness
1 reference
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https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Misregulation of gene expression in primary fibroblasts lacking poly(ADP-ribose) polymerase
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
How NF-kappaB is activated: the role of the IkappaB kinase (IKK) complex
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
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7 January 2021
based on heuristic
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The Rel/NF-kappa B family: friend and foe.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibitors of ADP-ribosylation impair inducible nitric oxide synthase gene transcription through inhibition of NF kappa B activation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Poly (ADP-ribose) polymerase is involved in PMA-induced activation of HIV-1 in U1 cells by modulating the LTR function.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Defective induction but normal activation and function of p53 in mouse cells lacking poly-ADP-ribose polymerase
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Chromosomal aberrations in PARP(-/-) mice: genome stabilization in immortalized cells by reintroduction of poly(ADP-ribose) polymerase cDNA.
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Poly(ADP-ribose) binds to specific domains of p53 and alters its DNA binding functions
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Poly(ADP-ribose) binds to specific domains in DNA damage checkpoint proteins
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Roles of poly(ADP-ribosyl)ation and PARP in apoptosis, DNA repair, genomic stability and functions of p53 and E2F-1.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Compensatory expression of p73 in PARP-deficient mouse fibroblasts as response to a reduced level of regularly spliced wild-type p53 protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Possible role of NF-kappaB and p53 in the glutamate-induced pro-apoptotic neuronal pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of human p53 requires synergistic activation of transcription from the p53 promoter by AP-1, NF-kappaB and Myc/Max
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Role of NF-κB in p53-mediated programmed cell death
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transcriptional cross talk between NF-kappaB and p53.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901902-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0165-6147(00)01902-7
1 reference
stated in
Europe PubMed Central
PubMed ID
11879679
retrieved
26 June 2017
PubMed ID
11879679
1 reference
stated in
Europe PubMed Central
PubMed ID
11879679
retrieved
26 June 2017
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