(Q33797139)

29 July 2017

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title

How NF-kappaB is activated: the role of the IkappaB kinase (IKK) complex (English)

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29 July 2017

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M Karin

1

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PubMed ID

10602462

29 July 2017

language of work or name

English

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publication date

1 November 1999

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29 July 2017

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29 July 2017

18

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29 July 2017

6867-6874

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29 July 2017

49

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1203219

29 July 2017

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cites work

beta-catenin is a target for the ubiquitin-proteasome pathway

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

In vivo stimulation of I kappa B phosphorylation is not sufficient to activate NF-kappa B

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

NF-kappa B: ten years after

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

The NF-kappa B and I kappa B proteins: new discoveries and insights

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

An essential role for NF-kappaB in preventing TNF-alpha-induced cell death

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

A conserved signaling pathway: the Drosophila toll-dorsal pathway

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

Sequential DNA damage-independent and -dependent activation of NF-kappaB by UV

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

Involvement of regulatory and catalytic subunits of phosphoinositide 3-kinase in NF-kappaB activation.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

Regulation of DNA binding by Rel/NF-kappaB transcription factors: structural views

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

IKAP is a scaffold protein of the IkappaB kinase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

Phosphorylation of I kappa B alpha precedes but is not sufficient for its dissociation from NF-kappa B

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

Absence of tumor necrosis factor rescues RelA-deficient mice from embryonic lethality

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

Genetic approaches in mice to understand Rel/NF-kappaB and IkappaB function: transgenics and knockouts

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

Clinically relevant findings

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

Phylogenetic perspectives in innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

Active and inactive protein kinases: structural basis for regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

JNK or IKK, AP-1 or NF-kappaB, which are the targets for MEK kinase 1 action?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

Molecular mechanisms of constitutive NF-kappaB/Rel activation in Hodgkin/Reed-Sternberg cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

Ionizing radiation and short wavelength UV activate NF-kappaB through two distinct mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

Severe liver degeneration in mice lacking the IkappaB kinase 2 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

Identification of a cell protein (FIP-3) as a modulator of NF-kappaB activity and as a target of an adenovirus inhibitor of tumor necrosis factor alpha-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

IkappaB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

Activators and target genes of Rel/NF-kappaB transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

Aberrant rel/nfkb genes and activity in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

A gradient of cactus protein degradation establishes dorsoventral polarity in the Drosophila embryo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

Identification and characterization of an IkappaB kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

Nuclear localization of IkappaB alpha is mediated by the second ankyrin repeat: the IkappaB alpha ankyrin repeats define a novel class of cis-acting nuclear import sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

Alterations in NF-kappaB function in transgenic epithelial tissue demonstrate a growth inhibitory role for NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

Persistent activation of NF-kappaB by the tax transforming protein of HTLV-1: hijacking cellular IkappaB kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

Limb and skin abnormalities in mice lacking IKKalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

Embryonic lethality, liver degeneration, and impaired NF-kappa B activation in IKK-beta-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

NF-kappaB-inducing kinase and IkappaB kinase participate in human T-cell leukemia virus I Tax-mediated NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

Suppression of TNF-alpha-induced apoptosis by NF-kappaB

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

Inhibition of NF-kappa-B cellular function via specific targeting of the I-kappa-B-ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

Identification of the receptor component of the IkappaBalpha-ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

Direct Phosphorylation of IB by IKK and IKK: Discrimination Between Free and NF-B-Bound Substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

Elongator, a Multisubunit Component of a Novel RNA Polymerase II Holoenzyme for Transcriptional Elongation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

Failure of lymphopoiesis after adoptive transfer of NF-kappaB-deficient fetal liver cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

7 January 2021

Tyrosine phosphorylation of I kappa B-alpha activates NF-kappa B without proteolytic degradation of I kappa B-alpha

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

7 January 2021

Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-kappa b-inducing kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

7 January 2021

Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203219

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1203219

1 reference

PubMed ID

10602462

Dimensions Publication ID

29 July 2017

0 references

1 reference

PubMed ID

10602462