(Q30830001)

23 September 2017

Microscopic insights into the protein-stabilizing effect of trimethylamine N-oxide (TMAO) (English)

1 reference

23 September 2017

Jianqiang Ma

1

1 reference

23 September 2017

Ileana M Pazos

series ordinal

2

1 reference

23 September 2017

Feng Gai

series ordinal

3

1 reference

23 September 2017

language of work or name

English

0 references

publication date

27 May 2014

1 reference

Proceedings of the National Academy of Sciences of the United States of America

23 September 2017

1 reference

23 September 2017

111

1 reference

23 September 2017

23

1 reference

23 September 2017

8476-8481

1 reference

Cloud-based simulations on Google Exacycle reveal ligand modulation of GPCR activation pathways

23 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060645

Intrinsic structural heterogeneity and long-term maturation of amyloid β peptide fibrils

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060645

Snapshot of the equilibrium dynamics of a drug bound to HIV-1 reverse transcriptase

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060645

Cosolvent effects on protein stability

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060645

Solute's perspective on how trimethylamine oxide, urea, and guanidine hydrochloride affect water's hydrogen bonding ability

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060645

Molecular mechanism for the preferential exclusion of TMAO from protein surfaces

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060645

Fast dynamics of HP35 for folded and urea-unfolded conditions

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060645

A peptide's perspective of water dynamics

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060645

Conformational dynamics and stability of HP35 studied with 2D IR vibrational echoes

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060645

Two-dimensional infrared spectroscopy reveals the complex behaviour of an amyloid fibril inhibitor

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060645

Ribonuclease S dynamics measured using a nitrile label with 2D IR vibrational echo spectroscopy

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060645

Volume exclusion and H-bonding dominate the thermodynamics and solvation of trimethylamine-N-oxide in aqueous urea

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060645

Site-Specific Spectroscopic Reporters of the Local Electric Field, Hydration, Structure, and Dynamics of Biomolecules

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060645

Entropic stabilization of proteins by TMAO

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060645

Quantifying why urea is a protein denaturant, whereas glycine betaine is a protein stabilizer

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060645

Tidal surge in the M2 proton channel, sensed by 2D IR spectroscopy

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060645

Dynamics of the folded and unfolded villin headpiece (HP35) measured with ultrafast 2D IR vibrational echo spectroscopy

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060645

The Two Dimensional Vibrational Echo of a Nitrile Probe of the Villin HP35 Protein.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060645

2D IR photon echo spectroscopy reveals hydrogen bond dynamics of aromatic nitriles

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060645

Counteraction of urea by trimethylamine N-oxide is due to direct interaction

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060645

Strategies for extracting structural information from 2D IR spectroscopy of amyloid: application to islet amyloid polypeptide

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060645

2D IR provides evidence for mobile water molecules in beta-amyloid fibrils

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060645

Trimethylamine N-oxide influence on the backbone of proteins: an oligoglycine model

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060645

Quantitative determination of site-specific conformational distributions in an unfolded protein by solid-state nuclear magnetic resonance

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060645

Empirical amide I vibrational frequency map: application to 2D-IR line shapes for isotope-edited membrane peptide bundles.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060645

Urea denaturation by stronger dispersion interactions with proteins than water implies a 2-stage unfolding

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060645

Effects of denaturants and osmolytes on proteins are accurately predicted by the molecular transfer model

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060645

Tracking fiber formation in human islet amyloid polypeptide with automated 2D-IR spectroscopy

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060645

Urea-amide preferential interactions in water: quantitative comparison of model compound data with biopolymer results using water accessible surface areas

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060645

The effects of cosolutes on protein dynamics: the reversal of denaturant-induced protein fluctuations by trimethylamine N-oxide

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060645

Predicting the energetics of osmolyte-induced protein folding/unfolding.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060645

Organic osmolytes as compatible, metabolic and counteracting cytoprotectants in high osmolarity and other stresses

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060645

Osmolyte trimethylamine-N-oxide does not affect the strength of hydrophobic interactions: origin of osmolyte compatibility

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060645

Counteraction of urea-induced protein denaturation by trimethylamine N-oxide: a chemical chaperone at atomic resolution

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060645

Measuring the stability of partly folded proteins using TMAO.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060645

The molecular mechanism of stabilization of proteins by TMAO and its ability to counteract the effects of urea

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060645

A naturally occurring protective system in urea-rich cells: mechanism of osmolyte protection of proteins against urea denaturation

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060645

Living with water stress: evolution of osmolyte systems

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060645

Destabilization of the hydrogen-bond structure of water by the osmolyte trimethylamine N-oxide.

14 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1403224111

Is a Methyl Group Always Hydrophobic? Hydrophilicity of Trimethylamine-N-oxide, Tetramethyl Urea and Tetramethylammonium Ion

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1403224111

Raman spectroscopic signatures of noncovalent interactions between trimethylamine N-oxide (TMAO) and water.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1403224111

Double resolution model for studying TMAO/water effective interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1403224111

Effects of urea, tetramethyl urea, and trimethylamine N-oxide on aqueous solution structure and solvation of protein backbones: a molecular dynamics simulation study

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1403224111

Effects of the osmolyte TMAO (Trimethylamine-N-oxide) on aqueous hydrophobic contact-pair interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1403224111

Trimethylamine-N-oxide-induced folding of alpha-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1403224111

Hydrogen Exchange Kinetics of RNase A and the Urea:TMAO Paradigm

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1403224111

Effects of urea and trimethylamine-N-oxide on the properties of water and the secondary structure of hen egg white lysozyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1403224111

Structural thermodynamics of protein preferential solvation: osmolyte solvation of proteins, aminoacids, and peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1403224111

Using nitrile-derivatized amino acids as infrared probes of local environment

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1403224111

Frequency-frequency correlation functions and apodization in two-dimensional infrared vibrational echo spectroscopy: a new approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1403224111

Time-resolved infrared study of the helix-coil transition using (13)C-labeled helical peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1403224111

Urea interactions with protein groups: a volumetric study

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1403224111

Preferential interactions of proteins with salts in concentrated solutions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1403224111

The hydrogen bond network structure within the hydration shell around simple osmolytes: urea, tetramethylurea, and trimethylamine-N-oxide, investigated using both a fixed charge and a polarizable water model

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1403224111

Solvent-dependent spectral diffusion in a hydrogen bonded "vibrational aggregate".

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1403224111

Impact of protein denaturants and stabilizers on water structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1403224111

Urea's action on hydrophobic interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1403224111

Efficacy of macromolecular crowding in forcing proteins to fold

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060645

Modulation of Hydrophobic Effect by Cosolutes

25 November 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1403224111

Distinct water species confined at the interface of a phospholipid membrane

21 January 2018

1 reference

12 December 2020

Observation of immobilized water molecules around hydrophobic groups

1 reference

12 December 2020

Thermodynamic characterization of interactions of native bovine serum albumin with highly excluded (glycine betaine) and moderately accumulated (urea) solutes by a novel application of vapor pressure osmometry

1 reference

12 December 2020

Structure and interaction in aqueous urea-trimethylamine-N-oxide solutions

1 reference

12 December 2020

Influence of osmolytes on protein and water structure: a step to understanding the mechanism of protein stabilization

1 reference

12 December 2020

Vibrational solvatochromism and electrochromism of infrared probe molecules containing C≡O, C≡N, C=O, or C-F vibrational chromophore

1 reference

12 December 2020

Trimethylamine N-oxide (TMAO) and tert-butyl alcohol (TBA) at hydrophobic interfaces: insights from molecular dynamics simulations

1 reference

12 December 2020

Methyl groups of trimethylamine N-oxide orient away from hydrophobic interfaces

1 reference

12 December 2020

Hydrophobic Molecules Slow Down the Hydrogen-Bond Dynamics of Water

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1403224111

1 reference

release_h5kjpy2plvfqrbxz4gnymo2fv4

23 September 2017

0 references

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/h5kjpy2plvfqrbxz4gnymo2fv4

24 November 2022

mapped directly with Wikidata item

1 reference

23 September 2017

1 reference