(Q30972892)

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Stoichiometry of base excision repair proteins correlates with increased somatic CAG instability in striatum over cerebellum in Huntington's disease transgenic mice

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14 February 2020

Stoichiometry of base excision repair proteins correlates with increased somatic CAG instability in striatum over cerebellum in Huntington's disease transgenic mice (English)

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14 February 2020

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Huntington's disease

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inferred from title

5

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14 February 2020

Karine Merienne

6

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14 February 2020

author name string

Agathi-Vassiliki Goula

1

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14 February 2020

Brian R Berquist

2

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14 February 2020

David M Wilson

3

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14 February 2020

Vanessa C Wheeler

4

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14 February 2020

publication date

4 December 2009

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14 February 2020

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14 February 2020

5

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14 February 2020

12

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14 February 2020

e1000749

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14 February 2020

copyright license

Creative Commons CC0 License

4 December 2009

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April 2022 Public Data File from Crossref

copyright status

copyrighted, dedicated to the public domain by copyright holder

0 references

Coordination between polymerase beta and FEN1 can modulate CAG repeat expansion.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778875

21 June 2018

CTG/CAG repeat instability is modulated by the levels of human DNA ligase I and its interaction with proliferating cell nuclear antigen: a distinction between replication and slipped-DNA repair

1 reference

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21 June 2018

Somatic expansion of the Huntington's disease CAG repeat in the brain is associated with an earlier age of disease onset

1 reference

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21 June 2018

MSH2 ATPase domain mutation affects CTG*CAG repeat instability in transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778875

21 June 2018

Long patch base excision repair proceeds via coordinated stimulation of the multienzyme DNA repair complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778875

21 June 2018

DNA repair in mammalian cells: Base excision repair: the long and short of it.

1 reference

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21 June 2018

Intergenerational and striatal CAG repeat instability in Huntington's disease knock-in mice involve different DNA repair genes

1 reference

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21 June 2018

DNA polymerase beta-catalyzed-PCNA independent long patch base excision repair synthesis: a mechanism for repair of oxidatively damaged DNA ends in post-mitotic brain

1 reference

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21 June 2018

Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice

1 reference

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21 June 2018

Characterization of abasic endonuclease activity of human Ape1 on alternative substrates, as well as effects of ATP and sequence context on AP site incision

1 reference

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21 June 2018

DNA instability in postmitotic neurons

1 reference

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21 June 2018

Features of trinucleotide repeat instability in vivo

1 reference

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21 June 2018

HMGB1 is a cofactor in mammalian base excision repair

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778875

21 June 2018

Factors associated with HD CAG repeat instability in Huntington disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778875

21 June 2018

OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778875

21 June 2018

Triplet repeat mutation length gains correlate with cell-type specific vulnerability in Huntington disease brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778875

21 June 2018

Haploinsufficiency of yeast FEN1 causes instability of expanded CAG/CTG tracts in a length-dependent manner

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778875

21 June 2018

Coordination of steps in single-nucleotide base excision repair mediated by apurinic/apyrimidinic endonuclease 1 and DNA polymerase beta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778875

21 June 2018

Base damage and single-strand break repair: mechanisms and functional significance of short- and long-patch repair subpathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778875

21 June 2018

Oxidative damage in Huntington's disease pathogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778875

21 June 2018

Repeat instability: mechanisms of dynamic mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778875

21 June 2018

Dysregulation of the peroxisome proliferator-activated receptor target genes by XPD mutations

1 reference

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21 June 2018

Genetic instability induced by overexpression of DNA ligase I in budding yeast

1 reference

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21 June 2018

Pms2 is a genetic enhancer of trinucleotide CAG.CTG repeat somatic mosaicism: implications for the mechanism of triplet repeat expansion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778875

21 June 2018

Gene regulation and DNA damage in the ageing human brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778875

21 June 2018

Flap endonuclease 1: a central component of DNA metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778875

21 June 2018

Inhibition of Ape1 nuclease activity by lead, iron, and cadmium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778875

21 June 2018

Nuclease-deficient FEN-1 blocks Rad51/BRCA1-mediated repair and causes trinucleotide repeat instability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778875

21 June 2018

Novel nuclear and mitochondrial glycosylases revealed by disruption of the mouse Nth1 gene encoding an endonuclease III homolog for repair of thymine glycols

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778875

21 June 2018

DNA substrates containing defined oxidative base lesions and their application to study substrate specificities of base excision repair enzymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778875

21 June 2018

FEN1 stimulation of DNA polymerase beta mediates an excision step in mammalian long patch base excision repair.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778875

21 June 2018

A method for detecting abasic sites in living cells: age-dependent changes in base excision repair

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778875

21 June 2018

Inhibition of FEN-1 processing by DNA secondary structure at trinucleotide repeats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778875

21 June 2018

The RAD2 domain of human exonuclease 1 exhibits 5' to 3' exonuclease and flap structure-specific endonuclease activities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778875

21 June 2018

Msh2 deficiency prevents in vivo somatic instability of the CAG repeat in Huntington disease transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778875

21 June 2018

Length-dependent gametic CAG repeat instability in the Huntington's disease knock-in mouse

1 reference

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21 June 2018

Structural analysis of slipped-strand DNA (S-DNA) formed in (CTG)n. (CAG)n repeats from the myotonic dystrophy locus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778875

21 June 2018

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778875

21 June 2018

Trinucleotide repeat length instability and age of onset in Huntington's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778875

21 June 2018

Somatic and gonadal mosaicism of the Huntington disease gene CAG repeat in brain and sperm.

1 reference

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21 June 2018

Trinucleotide repeats that expand in human disease form hairpin structures in vitro

1 reference

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21 June 2018

Dramatic tissue-specific mutation length increases are an early molecular event in Huntington disease pathogenesis

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000749

21 January 2018

Mismatch repair gene Msh2 modifies the timing of early disease in Hdh(Q111) striatum

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000749

21 January 2018

Trinucleotide expansion in haploid germ cells by gap repair

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000749

21 January 2018

Repair and mutagenesis at oxidized DNA lesions in the developing brain of wild-type and Ogg1-/- mice.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000749

21 January 2018

Mitochondrial and nuclear DNA-repair capacity of various brain regions in mouse is altered in an age-dependent manner.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000749

21 January 2018

Instability of highly expanded CAG repeats in mice transgenic for the Huntington's disease mutation.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000749

21 January 2018

Ape1 abasic endonuclease activity is regulated by magnesium and potassium concentrations and is robust on alternative DNA structures

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000749

21 January 2018

Fen1 does not control somatic hypermutability of the (CTG)(n)*(CAG)(n) repeat in a knock-in mouse model for DM1.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000749

21 January 2018

Modulation of the 5'-deoxyribose-5-phosphate lyase and DNA synthesis activities of mammalian DNA polymerase beta by apurinic/apyrimidinic endonuclease 1.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000749

21 January 2018

Concerted action of exonuclease and Gap-dependent endonuclease activities of FEN-1 contributes to the resolution of triplet repeat sequences (CTG)n- and (GAA)n-derived secondary structures formed during maturation of Okazaki fragments

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000749

21 January 2018

Mapping the protein-DNA interface and the metal-binding site of the major human apurinic/apyrimidinic endonuclease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19997493

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alternative structures in duplex DNA formed within the trinucleotide repeats of the myotonic dystrophy and fragile X loci

1 reference

https://pubmed.ncbi.nlm.nih.gov/19997493

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expansion and length-dependent fragility of CTG repeats in yeast

1 reference

https://pubmed.ncbi.nlm.nih.gov/19997493

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Slipped (CTG)*(CAG) repeats can be correctly repaired, escape repair or undergo error-prone repair

1 reference

https://pubmed.ncbi.nlm.nih.gov/19997493

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PGEN.1000749

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19997493%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19997493%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19997493%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

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