(Q30977920)

27 June 2017

title

Computer-aided design of a factor Xa inhibitor by using MCSS functionality maps and a CAVEAT linker search (English)

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27 June 2017

main subject

computer-aided design

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Yasunobu Takano

1

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27 June 2017

Masahiro Koizumi

2

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27 June 2017

Reiko Takarada

3

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27 June 2017

Midori Takimoto Kamimura

4

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27 June 2017

Ryszard Czerminski

5

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27 June 2017

Tohru Koike

6

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27 June 2017

publication date

1 November 2003

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Journal of Molecular Graphics & Modelling

27 June 2017

published in

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27 June 2017

volume

22

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27 June 2017

issue

2

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27 June 2017

page(s)

105-114

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Discovery of 1-[3-(aminomethyl)phenyl]-N-3-fluoro-2'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a highly potent, selective, and orally bioavailable inhibitor of blood coagulation factor Xa.

27 June 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2803%2900140-2

7 January 2021

The design and synthesis of noncovalent factor Xa inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2803%2900140-2

7 January 2021

Synthetic inhibitors of serine proteinases. XVI. Influence of 3- and 4-amidinobenzyl derivatives on the formation and action of thrombin

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2803%2900140-2

7 January 2021

Strategies for anticoagulation with synthetic protease inhibitors. Xa inhibitors versus thrombin inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2803%2900140-2

7 January 2021

Dibasic (Amidinoaryl)propanoic Acid Derivatives as Novel Blood Coagulation Factor Xa Inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2803%2900140-2

7 January 2021

Molecular model of an interaction between factor Xa and DX-9065a, a novel factor Xa inhibitor: Contribution of the acetimidoylpyrrolidine moiety of the inhibitor to potency and selectivity for serine proteases

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2803%2900140-2

7 January 2021

Tick anticoagulant peptide (TAP) is a novel inhibitor of blood coagulation factor Xa

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2803%2900140-2

7 January 2021

Structure of human des(1-45) factor Xa at 2.2 A resolution

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2803%2900140-2

7 January 2021

X-ray structure of active site-inhibited clotting factor Xa. Implications for drug design and substrate recognition

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2803%2900140-2

7 January 2021

Structural basis for chemical inhibition of human blood coagulation factor Xa

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2803%2900140-2

7 January 2021

Functionality maps of binding sites: a multiple copy simultaneous search method

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2803%2900140-2

7 January 2021

Multiple copy simultaneous search and construction of ligands in binding sites: application to inhibitors of HIV-1 aspartic proteinase

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2803%2900140-2

7 January 2021

CAVEAT: a program to facilitate the design of organic molecules

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2803%2900140-2

7 January 2021

Structure-based design of six novel classes of nonpeptide antagonists of the bradykinin B2 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2803%2900140-2

7 January 2021

Free R value: a novel statistical quantity for assessing the accuracy of crystal structures

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2803%2900140-2

7 January 2021

10.1016/S1093-3263(03)00140-2

Identifiers

DOI

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27 June 2017

1 reference